Could a diabetes drug heal Crohn's gut damage?

NCT ID NCT06976853

Recruiting now Disease control Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests tirzepatide, a drug used for diabetes, in 60 adults with Crohn's disease who have active inflammation in the small bowel despite other treatments. The goal is to see if tirzepatide can heal the gut lining better than switching to another standard biologic therapy. Researchers will check healing via colonoscopy and track side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tirzepatide
What this could lead to: If successful, tirzepatide could offer a new option for healing intestinal damage in Crohn's disease patients who don't respond to current treatments.
What could go wrong: This is an early Phase 2 trial with only 60 participants, so results may not apply to everyone. Tirzepatide may cause side effects like injection-site reactions or gastrointestinal issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease small bowel Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE (CD)

Contacts and locations

Locations

Cedars-Sinai Medical Center
NOT_YET_RECRUITING

Beverly Hills, California, 90211, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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