CROHN DISEASE (CD)

This study tests whether increasing the dose of guselkumab can help people with Crohn's disease who don't get better with standard doses. About 210 adults with active Crohn's will receive guselkumab, and after 12 weeks, those who haven't responded will get a higher dose more ofte…

This pilot study tests a new procedure for people with Crohn's disease who have anal fistulas that haven't healed with standard treatments. Doctors take a small amount of fat from the patient's belly, process it mechanically in the same surgery, and inject it into the fistula tra…

This study tests whether stem cells from a donor can help control Crohn's disease, a chronic gut condition causing pain and diarrhea. About 46 adults will receive either stem cells or a placebo through IV infusions over 16 weeks. Researchers will track symptom changes and side ef…

This study tests whether adding a low dose of upadacitinib (a JAK inhibitor) to a standard TNF inhibitor (like infliximab or adalimumab) works better than simply increasing the dose of the TNF inhibitor alone for people with moderate-to-severe Crohn's disease. About 312 adults wh…

This study tests the safety of giving a second injection of a patient's own frozen fat-derived cells (stromal vascular fraction) to treat anal fistulas that didn't heal in a previous trial. About 25 adults with Crohn's disease who still have active fistulas will receive the injec…

This study tests a new strategy to prevent Crohn's disease from returning after bowel surgery. Instead of waiting 6 months for a colonoscopy, doctors will use a simple stool test at 3 months to decide if treatment needs to be stepped up earlier. The goal is to reduce the number o…

This study tests tirzepatide, a drug used for diabetes, in 60 adults with Crohn's disease who have active inflammation in the small bowel despite other treatments. The goal is to see if tirzepatide can heal the gut lining better than switching to another standard biologic therapy…

This study tests if the drug mirikizumab can heal damage deep in the gut wall in people with Crohn's disease. About 75 adults with active symptoms and inflammation seen on MRI will receive the drug. The main goal is to see if the gut shows at least 25% improvement after 24 weeks.

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to the standard drug infliximab helps children with Crohn's disease feel better and stay in remission longer. About 140 children starting infliximab will be randomly assigned to receive the diet plus …

This Canadian study is testing whether switching to the drug guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who didn't respond well enough to ustekinumab. Researchers will track symptoms, test results, and overall health in 200 participants over one ye…

This study tests whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to standard anti-TNF therapy can improve outcomes for people with active Crohn's disease or ulcerative colitis. Eighty adults starting anti-TNF drugs will be randomly assigned to eithe…

This study is testing whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce their dose of the biologic drug ustekinumab. Participants will either switch from injections every 4 weeks to every 8 weeks, or from every 8 weeks to every …

This study will follow about 4,000 people who have received a fecal microbiota transplant (FMT) — a procedure that transfers gut bacteria from a healthy donor to restore balance in the gut. It aims to see how well FMT works over 3 months, 1 year, and 5 years for conditions like r…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) remember to take their medications and manage their symptoms. About 70 teens aged 13-17 will either use the full app with reminders and challenges or just a si…

This study tests whether a daily cranberry supplement can help restore healthy gut bacteria in adults with Crohn's disease. Fifty participants will take either the cranberry supplement or a placebo for 10 weeks. Researchers will track changes in gut bacteria, inflammation, and sy…

This study tests a new surgery for people with Crohn's disease in the last part of the small intestine. The surgery removes the diseased section and nearby fatty tissue, then reconnects the bowel in a special way (Kono-S anastomosis). The goal is to see if this lowers the chance …

This study tests an oral drug called EXL01 to see if it can prevent Crohn's disease from coming back after bowel surgery. About 80 adults who recently had surgery for Crohn's will receive either EXL01 or a placebo for up to 24 weeks. Doctors will use a camera to check the bowel f…

This study investigates whether advanced treatments for Crohn's disease also improve sleep quality. Adults with active Crohn's who are about to start a new advanced therapy will wear a Fitbit Inspire 3 for five days at three different times: before treatment, at week 4, and at we…

This study is looking for genetic clues that might predict how well people with inflammatory bowel disease (IBD) will respond to a common treatment called anti-TNF therapy. Researchers will collect blood samples from 40 patients who have not used anti-TNF before and track their r…

This study tests whether a simple blood test that reads epigenetic markers can help doctors pick the best biologic drug (ustekinumab or vedolizumab) for adults with active Crohn's disease. 378 participants will be randomly assigned to either have their treatment guided by this te…

This study looks at whether a protein in the blood called LRG can accurately show how active Crohn's disease or ulcerative colitis is in the gut. Researchers will compare LRG levels with standard endoscopic and symptom scores in 100 European adults. If successful, LRG could becom…

This study tests whether drinking 1.5 liters of water before an MRI scan can give doctors clear images of the small bowel in people with Crohn's disease, compared to the standard polyethylene glycol (PEG) prep. About 194 participants will be randomly assigned to water or PEG, and…

This study is testing whether a simple ultrasound can accurately measure muscle loss in people with inflammatory bowel disease (Crohn's or colitis). Currently, doctors use CT scans to check for muscle wasting, but CT involves radiation and is not always available. Researchers wil…

This study is a large registry that will follow 10,000 people with inflammatory bowel disease (IBD) in Germany over many years. Its goal is to collect real-world information on how well treatments work, how the disease changes over time, and how it affects patients' daily lives. …

This study looks at whether teaching children and teens with inflammatory bowel disease (IBD) about ultra-processed foods (like packaged snacks and sugary drinks) can help them eat less of them. About 120 participants will complete online food diaries and receive either nutrition…