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New hope for IBD patients: switching to guselkumab after ustekinumab fails

NCT ID NCT07245394

Recruiting now Disease control Sponsor: TIDHI Innovation Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 3 times

Summary

This Canadian study is testing whether switching to the drug guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who didn't respond well enough to ustekinumab. Researchers will track symptoms, test results, and overall health in 200 participants over one year. The goal is to see if this switch can lead to better disease control without worsening endoscopic findings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Guselkumab (Tremfya)
What this could lead to
If successful, this could show that switching to guselkumab is a good option for people with IBD who didn't get enough relief from ustekinumab, offering better symptom control.
What could go wrong
This is an observational study, not a controlled trial, so results may be less definitive. It's also relatively small (200 people) and only follows participants for one year, so long-term benefits or risks are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease indeterminate colitis inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE (CD) IBD-UNCLASSIFIED (IBD-U) INFLAMMATORY BOWEL DISEASE (IBD) ULCERATIVE COLITIS (UC)

Contacts and locations

Locations

  • Abp Research Services Corporation

    RECRUITING

    Oakville, Ontario, L6L 5L7, Canada

  • Barrie GI Associates

    RECRUITING

    Barrie, Ontario, L4M 7G1, Canada

    Contact Email: •••••@•••••

  • Brampton Gastroenterology Research Group Inc

    RECRUITING

    Brampton, Ontario, L6S 0C1, Canada

    Contact Email: •••••@•••••

  • GNRR Digestive Clinics and Research Center Inc.

    RECRUITING

    Brampton, Ontario, L6S 0E2, Canada

    Contact Email: •••••@•••••

  • Hamilton Health Sciences Corporation

    NOT_YET_RECRUITING

    Hamilton, Ontaio, L8L 2X2, Canada

  • LDDI Clinical Trials Inc. dba London Digestive Disease Institute

    RECRUITING

    London, Ontario, N6K 1M6, Canada

  • MA MacMillan

    RECRUITING

    Fredericton, New Brunswick, E3B 1J5, Canada

  • Taunton Surgical Center

    RECRUITING

    Oshawa, Ontario, L1J 0C7, Canada

  • The Research Institute of the McGill University Health Centre

    RECRUITING

    Montreal, Quebec, H3G 1A4, Canada

  • Toronto Immune and Digestive Health Institute

    RECRUITING

    Toronto, Ontario, M6A3B4, Canada

  • University of Calgary

    RECRUITING

    Calgary, Alberta, T2N 4Z6, Canada

  • West Gta Research Inc.

    RECRUITING

    Mississauga, Ontario, L5M 2S4, Canada

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