INFLAMMATORY BOWEL DISEASE (IBD)

This phase 2 trial tests a drug called DISC-0974 in 21 adults with inflammatory bowel disease (IBD) who also have anemia caused by inflammation. The study aims to see if the drug safely raises hemoglobin levels compared to a placebo. Participants receive injections of either DISC…

This study tests a once-daily food supplement designed to improve gut bacteria in people with mild-to-moderate ulcerative colitis. About 162 adults will take either the supplement or a placebo for 24 weeks, alongside their usual treatment. The goal is to see if the supplement hel…

This study follows 200 adults with Crohn's disease or ulcerative colitis who are prescribed Zymfentra as part of their regular care. Participants answer online surveys about their bowel habits for one year to see if symptoms improve. The goal is to understand how effective this m…

This Phase 2 study is testing two new drugs, MT-501 and MT-201, in 140 adults with moderate-to-severe Crohn's disease or ulcerative colitis. The goal is to see if these treatments are safe and can improve symptoms and gut healing. Researchers will monitor side effects and measure…

This study is testing an upgraded amino acid-based nutritional supplement for 30 children and adults who have severe gut problems like inflammatory bowel disease, short bowel syndrome, or severe allergies. Participants will use the supplement as part of their diet for 28 days. Re…

This Canadian study is testing whether switching to the drug guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who didn't respond well enough to ustekinumab. Researchers will track symptoms, test results, and overall health in 200 participants over one ye…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) remember to take their medications and manage their symptoms. About 70 teens aged 13-17 will either use the full app with reminders and challenges or just a si…

This study looks at 200 adults with inflammatory bowel disease (IBD) who are hospitalized due to worsening symptoms. Researchers want to see if testing blood or stool for CMV (a common virus) is as accurate as the standard method of testing a tissue sample from the colon. The goa…

This pilot study tests whether the MyIBDDiet app helps people with inflammatory bowel disease (IBD) learn about and follow an anti-inflammatory diet. Forty adults with IBD who are not in a flare will use the app for 30 to 60 days and complete surveys about its ease of use and the…

This study looks at whether people with moderate-to-severe inflammatory bowel disease (IBD) need to take a steroid (dexamethasone) before each infliximab infusion to prevent allergic reactions. Researchers will compare those who get the steroid routinely with those who only get i…

This study tests whether a 12-week personalized aerobic exercise program, done at home with telemedicine guidance, can improve fitness, disease control, and quality of life in adults with inactive or mildly active inflammatory bowel disease (IBD). Twenty-eight participants will e…

This study looks at whether a 12-week remote exercise program can improve quality of life for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 72 adults with IBD will use a smartphone app to follow guided physical activities at…

This early-stage study tests a new drug called PVT401 in 36 healthy volunteers to see if it is safe and how the body handles it. Participants receive either the drug or a placebo by IV, either as a single dose or multiple doses over five weeks. The goal is to gather safety data b…

This study aims to find new markers in the blood that can detect an imbalance of gut bacteria linked to inflammatory bowel disease (IBD). Researchers will compare 60 people with IBD and 60 people without IBD by collecting stool, blood, and tissue samples. The goal is to develop a…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at whether teaching children and teens with inflammatory bowel disease (IBD) about ultra-processed foods (like packaged snacks and sugary drinks) can help them eat less of them. About 120 participants will complete online food diaries and receive either nutrition…

This study is for adults in South Korea with ulcerative colitis or Crohn's disease who are already taking vedolizumab injections. Researchers will look at medical records to track side effects and how well the treatment works. No new medicine or treatment is given—this is just an…

This study looks at whether microplastics are found more often in children with inflammatory bowel disease (IBD) compared to healthy children. Researchers will collect samples of tissue, blood, urine, and stool from 40 children during routine endoscopy. No treatment is given—the …

This study is a large registry that will collect information from over 4,000 people with Crohn's disease or ulcerative colitis in Argentina. Doctors will record details about patients' diagnosis, treatments, and any safety issues like infections. The goal is to better understand …