Blood test may end guesswork in Crohn's drug choice
NCT ID NCT07363044
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a simple blood test that reads epigenetic markers can help doctors pick the best biologic drug (ustekinumab or vedolizumab) for adults with active Crohn's disease. 378 participants will be randomly assigned to either have their treatment guided by this test or by standard doctor choice. The goal is to see if the test leads to better remission and fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Epigenetic blood test (EpiPredict) to guide biologic selection (ustekinumab or vedolizumab)
What this could lead to
If successful, this test could help doctors pick the most effective biologic for each Crohn's patient, reducing trial-and-error and improving outcomes.
What could go wrong
This is an early-phase study with 378 participants, so results may not apply to everyone. The test may not reliably predict response, and some patients may still not respond to the chosen drug.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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AZ Delta VZW
RECRUITINGRoeselare, Belgium
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AZ Klina
RECRUITINGBrasschaat, Belgium
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AZ Maria Middelares
RECRUITINGGhent, Belgium
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AZ Oostende
RECRUITINGOstend, Belgium
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AZ Sint Lucas
RECRUITINGGhent, Belgium
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Agostino Gemelli University Policlinic
NOT_YET_RECRUITINGRoma, Italy
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Amsterdam UMC
RECRUITINGAmsterdam, Netherlands
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Azienda Ospedaliero Universitaria Careggi Padiglione San Luca Nuovo
RECRUITINGFlorence, Italy
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CHU UCL Namur asbl Site Godinne
RECRUITINGYvoir, Belgium
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Cambridge University Hospitals NHS Trust
RECRUITINGCambridge, United Kingdom
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Cardiff & Vale UHB
RECRUITINGLlandough, United Kingdom
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Centre Hospitalier Universitaire (CHU) de Liege
RECRUITINGLiège, Belgium
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Elisabeth-TweeSteden Ziekenhuis (ETZ)
RECRUITINGTilburg, Netherlands
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Flevoziekenhuis Hospitaalweg 1
NOT_YET_RECRUITINGAlmere Stad, Netherlands
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GZA Antwerpen
NOT_YET_RECRUITINGAntwerp, Belgium
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Groupe sante CHC/Clique du MontLegia
RECRUITINGLiège, Belgium
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Guy's and St. Thomas' NHS Foundation Trust
RECRUITINGLondon, United Kingdom
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H.U.B. - Hôpital Erasme
RECRUITINGBrussels, Belgium
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Hampshire Hospital NHS Foundation Trust
RECRUITINGWinchester, United Kingdom
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Hull University Teaching Hospital NHS Trust
RECRUITINGCottingham, United Kingdom
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IRCCS "Saverio de Bellis", National Institute of Gastroenterology
NOT_YET_RECRUITINGCastellana Grotte, Italy
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IRCCS Ospedale San Raffaele
RECRUITINGMilan, Italy
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Imeldahospital
RECRUITINGBonheiden, Belgium
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King's College Hospital NHS Foundation Trust
RECRUITINGLondon, United Kingdom
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Maastricht UMC
RECRUITINGMaastricht, Netherlands
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Northern Care Alliance - Fairfield General Hospital
RECRUITINGBury, United Kingdom
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OLVG Oost
RECRUITINGAmsterdam, Netherlands
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Oxford University Hospitals NHS Foundation Trust
RECRUITINGOxford, United Kingdom
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Radboudumc
RECRUITINGNijmegen, Netherlands
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San Camillo-Forlanini Hospital
NOT_YET_RECRUITINGRome, Italy
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The Dudley Group NHS Foundation Trust
RECRUITINGDudley, United Kingdom
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UKC Ljubljana
NOT_YET_RECRUITINGLjubljana, Slovenia
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UOC di Gastroenterologia ed Endoscopia Digestiva
NOT_YET_RECRUITINGSan Giovanni Rotondo, Italy
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UZ Ghent
RECRUITINGGhent, Belgium
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UZ Leuven
RECRUITINGLeuven, Belgium
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UZ Leuven Gasthuisberg
RECRUITINGLeuven, Belgium
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Universitair Medisch Centrum Utrecht
RECRUITINGUtrecht, Netherlands
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Universitair Ziekenhuis Antwerpen (UZA)
RECRUITINGEdegem, Belgium
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University Hospital Southampton NHS Foundation Trust
RECRUITINGSouthampton, United Kingdom
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