CROHN DISEASE (CD)

This study tests whether the drug mirikizumab can heal deep intestinal damage in people with Crohn's disease. About 110 adults with active symptoms and visible inflammation on MRI will receive the drug and be monitored for 24 weeks. The goal is to see if the treatment reduces inf…

This early-stage study tests whether a probiotic called Clostridium butyricum, alone or with a sugar called trehalose, can help reduce scarring in the gut caused by Crohn's disease. Forty adults with a narrowed (stricturing) form of Crohn's will take one of four treatments for tw…

This early-phase study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose. Researchers will also look for early s…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 adults with long-term fatigue will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a large…

This study aims to see if data from smartwatches and grocery shopping habits can help detect when inflammatory bowel disease (Crohn's or colitis) is getting worse. About 80 adults on standard IBD treatments will wear a smartwatch and use a loyalty card to track their daily activi…

This study tests whether two fluorescent dyes attached to common IBD drugs (adalimumab and risankizumab) can show where the drugs go in the gut. About 30 adults with ulcerative colitis or Crohn's disease will receive the dyed drugs before a routine colonoscopy. The goal is to see…

This study looks at intestine tissue removed during surgery from 60 adults with Crohn's disease. Researchers will use special MRI scans and lab tests on the tissue to better understand the difference between active inflammation and permanent scarring. The goal is to improve futur…

This study looks at how taking vitamin D affects people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Over 12 months, 150 adults will take 2,000 IU of vitamin D daily and complete surveys, blood tests, and stool tests. The goal is to see…

This study aims to validate a risk score that predicts Crohn's disease in first-degree relatives (parents, siblings, children) of people with the condition. Researchers will collect blood samples and lifestyle information from 10,000 participants aged 16-35 across seven European …

This study looks at whether an MRI without a distension drink (which can cause vomiting or diarrhea) can still accurately measure inflammation in the small bowel for people with Crohn's disease. About 60 adults with Crohn's will get two MRIs in one week—one with the drink and one…

This study aims to better understand the symptoms of stricturing Crohn's disease by interviewing 15 adult patients. The goal is to identify which symptoms matter most to patients and how the disease affects daily life. This information will help create a more accurate clinical as…

This study looks at how diet affects inflammation in people with Crohn's disease or ulcerative colitis. Researchers want to see if using a stool test (calprotectin) to guide food choices reduces picky eating, and if a digital tool improves quality of life. About 140 participants …