CROHN DISEASE (CD)

This study tests a new treatment called DB-3Q for people with Crohn's disease that hasn't improved with standard therapies. DB-3Q is made from stem cells and may help reduce inflammation in the gut. The trial will enroll 36 adults and focus on safety and how well the treatment wo…

This early-stage study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose, while also looking at how well it work…

This early study tests whether a probiotic called Clostridium butyricum can help prevent or treat scarring in the gut caused by Crohn's disease. About 40 adults with a narrowing form of Crohn's will take the probiotic, a sugar called trehalose, both, or a placebo for two months b…

This study tests whether an AI-enhanced virtual reality cognitive behavioral therapy (VR/AI CBT) program can reduce anxiety and improve quality of life in people with inflammatory bowel disease (IBD). Seventy-six adults with IBD and moderate-to-severe anxiety will be randomly ass…

This study tests whether modafinil, a drug used for narcolepsy, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 participants will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a larger trial is possible, bu…

This study explores whether changes in heart rate, sleep, and activity measured by a person's own smartwatch can predict flare-ups in inflammatory bowel disease (IBD). Six hundred adults with Crohn's disease or ulcerative colitis who already own a compatible device will participa…

This study will interview 15 adults with stricturing Crohn's disease to learn which symptoms matter most to them and what early warning signs they notice. Researchers hope to use this information to create a better clinical assessment score. Participants will have a one-hour inte…

This study looks at whether an MRI without a bowel-distending drink (like PEG or mannitol) can still accurately measure inflammation in the small bowel of people with Crohn's disease. Many patients find these drinks hard to tolerate, causing vomiting or diarrhea. If skipping the …

This study will use powerful MRI scans on intestinal tissue removed during surgery from 60 people with Crohn's disease. The goal is to better tell apart active inflammation from permanent scarring, which is hard to do with current scans. By comparing MRI results with detailed tis…

This study tests whether fluorescent dyes attached to two IBD drugs (adalimumab and risankizumab) can show where the drugs go in the gut. 30 adults with ulcerative colitis or Crohn's disease will receive a low dose of the labelled drugs, then undergo a special camera procedure 2-…

This study aims to develop a risk score for Crohn's disease by following 10,000 first-degree relatives (parents, siblings, or children) of people with Crohn's. Participants aged 16 to 35 will give blood and stool samples and answer lifestyle questionnaires every six months. The g…

This study looks at whether taking a daily vitamin D supplement (2000 IU) for 12 months can improve the health and quality of life of people with Crohn's disease or ulcerative colitis. Researchers will track how well participants stick to the supplement and measure their vitamin …

This study tests whether data from a wearable device and grocery loyalty cards can help detect disease flares in people with Crohn's disease or ulcerative colitis. Eighty adults will wear a smartwatch and use a store card to track their health and food purchases. The goal is to d…