Mcgill University Health Centre/research Institute Of The Mcgill University Health Centre

This study tests whether taking oral vancomycin while on other antibiotics can prevent a repeat Clostridioides difficile infection (CDI) in people who had one in the last 120 days. Researchers will compare vancomycin to a placebo in 300 adults. Participants take the study drug tw…

This study tests whether tirzepatide, a weekly injection already used for type 2 diabetes, can help adults with type 1 diabetes use an automated insulin pump without needing to count carbohydrates at meals. About 105 participants will be randomly assigned to receive tirzepatide o…

This study tests whether two dietary supplements, HMB and 2-HOBA, can improve muscle mass, physical function, and overall health in adults aged 65 and older. Over 90 days, 120 participants will take one or both supplements or a placebo. Researchers will measure changes in muscle,…

This study tests whether adding communication counseling to a step-tracking program helps couples where one partner has type 2 diabetes walk more and improve blood sugar. About 200 couples will use Fitbits and get step goals. Half will also attend counseling sessions to improve t…

This study tests modified oral immunotherapy (OIT) protocols for peanut, milk, and egg allergies in 360 participants. The goal is to see if using lower doses or processed allergens can reduce allergic reactions during treatment while still helping people become desensitized to th…

This study looks at whether switching to the blood thinner dabigatran can improve outcomes for people with a serious staph bloodstream infection who are already taking other blood thinners. Researchers will compare those who switch to dabigatran with those who stay on their curre…

This study tests whether canagliflozin, a diabetes drug, can improve fluid removal and reduce scarring in people on peritoneal dialysis for kidney failure. Thirty adults will receive either the drug or a placebo for 26 weeks, then switch. The goal is to see if the drug helps the …

This study compares a newer pacing method called left bundle branch pacing (LBBP) with standard right ventricular pacing in 1,300 people who need a pacemaker for heart block. Standard pacing can sometimes weaken the heart over time, leading to heart failure. LBBP tries to mimic t…

This study tests whether social prescribing—connecting patients to community resources for issues like housing, income, or loneliness—can help women with heart failure better adhere to their medications and improve their quality of life. Researchers will enroll 200 women across f…

This study is testing whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce their dose of the biologic drug ustekinumab. Participants will either switch from injections every 4 weeks to every 8 weeks, or from every 8 weeks to every …

This study tests whether canagliflozin, a drug used for diabetes, can improve heart structure in people with advanced kidney disease (stage 4 or 5) or on dialysis. About 92 participants will receive either the drug or a placebo for 12 months, with heart changes measured by MRI. T…

This study is testing whether measuring spleen stiffness with a non-invasive scan can accurately diagnose and monitor portal hypertension in people with advanced chronic liver disease. Researchers will enroll 200 participants and track them over time to see if this simple test ca…

This phase 3 trial tests whether a gradual taper of vancomycin is as good as a 10-day course of fidaxomicin at preventing another C. difficile infection. About 500 adults with a first or second C. diff episode will be randomly assigned to one of the two treatments. The main goal …

This study aims to find a shorter, safer treatment for latent tuberculosis (TB) infection to prevent it from becoming active disease. About 1800 adults and children with a positive TB test will try one of several daily pill regimens lasting 1 to 4 months. The goal is to identify …

This study tests a walking program called Walk-BEST for people aged 70+ with osteoporosis. The program uses a sensor to improve walking and aims to reduce falls and fractures. Researchers want to see if it's practical and acceptable for 28 participants.

This pilot study tests whether a daily 10-minute paced breathing exercise (inhale 4 seconds, exhale 6 seconds) can help children and teens aged 9-18 recover from a concussion. Twenty participants will either do the breathing exercises at home for four weeks or receive usual care.…

This study compares three doses of a medicine called dexmedetomidine, added to the numbing drugs used for nerve blocks during arm surgery. The goal is to see if a higher dose keeps the arm numb and pain-free for longer. About 69 adults having surgery below the elbow will take par…

This study looks at whether dexamethasone, a drug often given during mastectomy to prevent nausea, might increase the risk of long-term pain. Researchers will compare women who receive the drug to those who receive a placebo, tracking pain levels three months after surgery. The g…

This study looks at whether a doctor's computer tool (MedSafer) and patient brochures (EMPOWER) can help reduce the use of potentially harmful medications in adults aged 60 and older with rheumatic diseases who take five or more regular drugs. Researchers will follow 100 particip…

This study looks at whether a new monitoring system can track the health of extremely low birth weight babies after their breathing tube is removed. The system combines standard vital signs with special sensors that measure oxygen levels in the brain and gut, and lung ventilation…

This study looks at whether the sound of bubbles from a CPAP machine can help doctors know if enough air pressure is reaching a premature baby's lungs. Researchers will study 30 preterm infants in the NICU, recording bubble sounds and comparing them to actual pressure measurement…

This study is testing whether a simple finger-prick blood spot can measure inflammatory markers as accurately as a standard blood draw from a vein. Researchers will collect both types of samples from 50 adults before and after a planned stressor, like a vaccine, which temporarily…

This study tests whether a biomarker signature (BV score) can help doctors decide when to use antibiotics for ICU patients. About 1,200 adults in intensive care who started antibiotics within the past 72 hours will be randomly assigned to have their treatment guided by the biomar…

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…

This study looks at how infertility and fertility treatments like IVF affect women's sexual function and behavior. About 500 women under 45 with infertility will fill out an anonymous questionnaire about their sexual desire, satisfaction, and activities. The goal is to help docto…

This study tests whether a new smartphone app called elleFA can help women with endometriosis track their symptoms and communicate better with their doctors. Twenty pre-menopausal women aged 18 and older will use the app for 6 months, completing monthly surveys and optional daily…

This study follows 30 people with Zellweger Spectrum Disorder over 5 years to understand how their vision changes over time. Participants will have yearly vision tests, physical exams, and blood work. The goal is to define the course of retinal degeneration and find the best ways…

This study looks at how to get more people in Canadian federal prisons to use needle exchange programs, which can help stop the spread of HIV and hepatitis C. Researchers will work in nine prisons, including five women's prisons, to find out what helps or hinders program use and …

This study follows people with peroxisome biogenesis disorders (PBD) to learn more about how the disease progresses. Researchers will collect medical records, test results, and images over time from up to 244 participants. No new treatments are being tested; the goal is to better…

This study tests whether a 12-week virtual exercise and education program is practical for people with end-stage kidney disease who are waiting for a transplant. About 30 participants will either do the program or receive usual care. The main goal is to see if enough people join,…