Mcgill University Health Centre/research Institute Of The Mcgill University Health Centre

This phase II trial tests whether adding simvastatin, a widely used cholesterol medication, to standard chemotherapy (with or without immunotherapy) can improve outcomes for people with gastroesophageal adenocarcinoma. About 184 patients will be randomly assigned to receive eithe…

This Phase 2 trial tests two forms of peanut oral immunotherapy in 57 people aged 4 to 30 with peanut allergy. One group gets standard blanched peanut protein, the other gets autoclaved (high-pressure heated) peanut protein, both in gradually increasing doses. The goal is to see …

This study looks at which second-choice treatment works best for a serious lung infection called PCP when the usual antibiotic cannot be used due to allergies, side effects, or failure. About 416 adults with weakened immune systems (from HIV, transplants, cancer, or other causes)…

This study looks at how long steroids should be given to adults with severe Pneumocystis pneumonia (PCP), a serious lung infection common in people with weakened immune systems. About 416 participants who improve within 10 days will either stop steroids early or continue for 21 d…

This study tests a wearable microwave sensor that monitors bladder fullness without needles or catheters. About 40 adults with spinal cord injury who use self-catheterization will wear the sensor while their bladder fills and empties. The goal is to see if the device can accurate…

Extremely preterm infants often have breathing issues that current monitors may miss. This study tests a wireless acoustic sensor placed on the baby's throat to more accurately detect pauses, shallow breaths, and irregular patterns. Researchers will compare the sensor to standard…

This study tests whether a high-resolution ultrasound technique, called micro-ultrasound, can find aggressive prostate cancers that standard MRI might miss. Researchers will enroll 90 men with low-risk prostate cancer who have negative or stable MRI results. Participants will get…

This study tests whether videos recorded by parents at home can help doctors detect early signs of cerebral palsy in very preterm infants (born before 29 weeks). Researchers will compare the accuracy of family-led recordings to standard professional assessments. If successful, th…

This study tests whether a personalized nutritional plan can prevent a serious brain condition called hepatic encephalopathy in people with liver cirrhosis who undergo a TIPS procedure. The trial will enroll 50 malnourished patients and compare the personalized diet to standard c…

This study tests a decision aid for people who have had a first blood clot and must decide whether to stop or continue blood thinners after at least 3 months of treatment. The aid provides balanced information on risks and benefits and helps clarify personal values. Researchers w…

This study will test a customized online health program for Canadian women Veterans and their families. The program includes health missions, peer support, and social connection to encourage physical activity and healthy habits. Researchers will track how many people complete the…

This study looks at whether a specially trained physical therapist can diagnose jaw disorders (like TMJ) as accurately as an oral surgeon. 70 people with jaw pain will be checked by both a physical therapist and a surgeon, and their diagnoses will be compared. The goal is to see …

This study looks at how levels of follicle-stimulating hormone (FSH) change during ovarian stimulation for IVF. Researchers will measure FSH, LH, and estradiol at several points during treatment in 500 women. They want to see if these hormone levels are linked to the number of eg…

This study aims to find the smallest amount of lidocaine needed to successfully numb the arm using a specific ultrasound-guided nerve block technique. Researchers will test different volumes of lidocaine in 60 adults aged 18-70, adjusting doses based on previous results. The goal…

This study looks at whether having a tattoo affects the chances of getting pregnant through IVF. Researchers will compare pregnancy rates in women with and without tattoos who are undergoing embryo transfer. The goal is to see if tattoo size, duration, or ink color play a role in…

This study looks at how five common tuberculosis drugs move into breast milk after a single dose. Sixty healthy breastfeeding women in Indonesia will each receive one drug, and researchers will measure drug levels in their blood and milk. The goal is to gather safety data so that…