Mcgill University Health Centre/research Institute Of The Mcgill University Health Centre

This study looks at the best way to give COVID-19 booster and flu shots to people with weakened immune systems (like those with rheumatoid arthritis, organ transplants, or HIV). It will compare getting both vaccines on the same day versus one month apart, and also test if getting…

This study tests whether canagliflozin, a diabetes medicine, can help people on peritoneal dialysis remove more fluid and reduce scarring of the belly lining. About 30 adults with kidney failure will receive either the drug or a placebo for 26 weeks, then switch. The goal is to s…

This study tests whether adding couples counseling to a step-counting program helps people with type 2 diabetes walk more and improve blood sugar. About 200 couples will join. Half will get step counters and step goals from their doctor, plus counseling sessions to improve commun…

This study tests different versions of oral immunotherapy (OIT) for people with peanut, milk, or egg allergies. The goal is to see if using lower doses or processed allergens can reduce the risk of severe allergic reactions during treatment while still helping patients become les…

This study tests if a newer pacing method, left bundle branch pacing, is better than the standard right ventricular pacing for people with heart block who need a pacemaker. Standard pacing can sometimes weaken the heart over time, leading to heart failure or death. The study will…

This study looks at whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce how often they take the biologic drug ustekinumab. Researchers will monitor blood levels, inflammation, and gut health to see if a lower dose still keeps the …

This study compares two treatments to prevent Clostridioides difficile (C. diff) infection from returning. About 500 adults with a first or second C. diff episode will receive either a vancomycin taper or a 10-day course of fidaxomicin. The goal is to see if the vancomycin taper …

This study tests whether canagliflozin, a drug used for diabetes, can improve heart structure in people with advanced kidney disease (stages 4 and 5) or those on dialysis. About 92 participants will receive either the drug or a placebo, and heart changes will be measured using MR…

This study looks at whether switching to a blood thinner called dabigatran can help people with a serious staph bloodstream infection. Participants are already taking a different blood thinner for conditions like atrial fibrillation or blood clots. The goal is to see if dabigatra…

This study tests whether social prescribing—a program that connects patients to community resources like housing, transportation, or mental health support—can help women with heart failure take their medications as prescribed and improve their quality of life. About 200 women wit…

This study tests whether taking oral vancomycin can prevent a repeat Clostridioides difficile infection in people who recently had one and now need another antibiotic. About 300 adults will be randomly assigned to receive vancomycin or a placebo while on other antibiotics and for…

This study looks at whether measuring spleen stiffness with ultrasound can safely detect and track dangerous liver pressure (portal hypertension) in people with advanced chronic liver disease. About 200 adults will have regular non-invasive scans instead of the usual invasive nee…

This study tests whether shorter daily pill regimens (1–2 months) can safely prevent latent tuberculosis infection from turning into active disease. About 1,800 adults and children with a positive TB test will take one of several experimental pill combinations or the standard 4-m…

This study tests three different doses of a drug called dexmedetomidine, added to the usual numbing medicine for a nerve block in the armpit area. The goal is to see if a higher dose can keep the arm numb and pain-free longer after elbow or hand surgery. About 69 adults having up…

This study tests whether doing a 10-minute paced breathing exercise every day for four weeks can help children and teens (ages 9-18) recover from a concussion. Participants either do the breathing exercises at home or receive usual care. The main goal is to see if the program is …

This study looks at how infertility and fertility treatments like IVF affect women's sexual function and behavior. About 500 women under 45 with infertility will fill out an anonymous questionnaire about their sexual desire, satisfaction, and activities. The goal is to help docto…

This study checks if a simple finger prick (dried blood spot) can measure inflammation markers as well as a standard blood draw from a vein. About 50 adults who are getting a vaccine or have a planned stressor will give both types of samples. The goal is to see if the finger-pric…

This study tests whether a 12-week virtual exercise and education program is practical for people waiting for a kidney transplant. It will enroll 30 pre-frail or frail adults. The goal is to see how many people sign up, stick with the program, and complete follow-ups, not to meas…

This study is testing whether a special blood test (biomarker signature) can help doctors in intensive care units (ICUs) make better decisions about when to use antibiotics. About 1,200 ICU patients who have started antibiotics will be randomly assigned to have their treatment gu…

This study aims to increase the use of needle and syringe programs in Canadian federal prisons to reduce the spread of HIV and hepatitis C among people who inject drugs. Researchers will work in nine prisons, including five women's prisons, to identify barriers and test strategie…

This study looks at 30 premature babies on bubble CPAP, a breathing machine. Researchers want to see if the bubbling sounds can tell them if the right air pressure is being delivered. The goal is to find a new, non-invasive way to monitor breathing support in the NICU.

This study is testing a new way to monitor very small preterm babies (born weighing less than 2.2 pounds) after their breathing tube is removed. The system combines standard vital signs with special sensors that measure oxygen levels in the brain and gut, and lung function. The g…

This study follows 244 people with peroxisome biogenesis disorders (PBD) and related conditions over time. Researchers collect medical records, test results, and imaging to better understand how the disease progresses. The goal is to improve care and identify standards of treatme…

This study follows 30 people with Zellweger Spectrum Disorder to see how their vision changes over time. Researchers will use yearly eye tests, blood work, and questionnaires to map the course of retinal degeneration. The goal is to find the best ways to monitor vision loss and p…

This study looks at whether a special tool for doctors and easy-to-read brochures for patients can help reduce the use of potentially harmful medications in adults aged 60 and older with rheumatic conditions like arthritis or lupus. Researchers will follow 100 participants for ab…

This study looks at whether dexamethasone, a drug often given during mastectomy to prevent nausea, might actually increase the chance of long-term pain after surgery. Researchers will follow 170 women for three months after their operation to compare pain levels between those who…

This study tests whether a new smartphone app called elleFA can help women with endometriosis track their symptoms and communicate better with their healthcare team. About 20 pre-menopausal women aged 18 and older with known or suspected endometriosis will use the app for 6 month…