Mcgill University Health Centre/research Institute Of The Mcgill University Health Centre

This study tests whether placing a pacemaker wire in a different part of the heart (left bundle) is better than the standard placement (right ventricle) for patients who need constant pacing due to heart block. Researchers want to see if the new placement reduces heart failure ev…

This study is testing if a diabetes medication called canagliflozin can improve heart structure and function in people with advanced kidney disease, including those on dialysis. About 92 participants will take either the drug or a placebo for one year, with doctors using heart MR…

This study aims to find the best way to give COVID-19 booster shots and seasonal flu vaccines to adults with weakened immune systems. Researchers want to know if getting both shots on the same day works as well as getting them a month apart, and if getting COVID boosters every 3 …

This study aims to see if providing doctors with a medication review tool and giving patients educational brochies can help safely reduce the number of potentially harmful or unnecessary medications taken by older adults with rheumatic diseases. It will involve about 100 particip…

This small pilot study is testing whether a virtual home-based exercise and education program is practical for frail patients waiting for a kidney transplant. The goal is to see if patients can and will follow the program, and to gather information to plan a larger future study. …

This study is testing whether patients with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce the frequency of their ustekinumab injections. Researchers want to see if patients can space out their shots from every 4 weeks to every 8 weeks, or from …

This study is testing a new medical device that combines two types of energy to treat a dangerous, fast heart rhythm called ventricular tachycardia (VT). The goal is to see if using pulsed field energy together with standard radiofrequency energy can create deeper, more effective…

This study is for people with a serious Staph blood infection who are already taking certain blood thinners. It will test if switching their medication to dabigatran, a blood thinner that may also fight the bacteria, leads to better recovery. Researchers will compare outcomes lik…

This study aims to make prison needle exchange programs work better in nine Canadian federal prisons. It focuses on helping people who inject drugs in prison access clean needles to prevent the spread of HIV and hepatitis C. Researchers will test different support strategies over…

This study is testing if 'social prescribing' can help women with heart failure take their medications and feel better. Social prescribing connects patients with a 'link worker' who helps them find community services for needs like transportation, housing, or loneliness. Research…

This study is testing whether using lower doses or processed versions of common food allergens can make oral immunotherapy safer while still effective. Researchers want to see if these modified approaches cause fewer allergic reactions during treatment while still helping people …

This study is testing whether a simple, non-invasive scan can accurately detect and monitor high blood pressure in the liver (portal hypertension) in people with advanced liver disease. Researchers will follow 200 participants to see if the scan results can predict serious liver …

This study aims to prevent repeat Clostridioides difficile (C. diff) infections in people who recently had one and need to take antibiotics again. It will test if taking oral vancomycin (an antibiotic) alongside the new antibiotic course can protect the gut and stop C. diff from …

This study aims to find shorter, safer drug regimens to prevent latent tuberculosis (TB) infection from turning into active disease. Researchers are testing 1-2 month daily pill courses against the current standard 4-month treatment in 1,800 adults and children. The goal is to id…

This study aims to find the best dose of a drug called dexmedetomidine to make a numbing injection for arm surgery last longer. Researchers will compare three different doses in 69 adults having elbow, forearm, or hand surgery. The main goal is to see which dose keeps the arm num…

This study is testing if a very low dose of fentanyl, given as a spray under the tongue, can help people with severe COPD breathe easier during exercise. It will involve about 40 participants who still struggle with breathlessness despite taking standard medications, including lo…

This study aims to see if the sounds from a breathing support machine (called bubble CPAP) can be used to monitor how well it's working for premature babies. Researchers will record sounds from the machine and measure the air pressure delivered to 30 infants in the NICU. The goal…

This study is testing whether a new monitoring system is practical to use for extremely premature babies after their breathing tube is removed. Researchers will observe 20 very small babies to see if combining multiple types of monitoring data helps doctors make better decisions …

This study aims to understand how infertility and the stress of fertility treatments like IVF affect women's sexual function and behavior. Researchers will ask about 500 women undergoing fertility care to complete anonymous questionnaires about their sexual desire, satisfaction, …

This study aims to understand how vision gets worse over time in people with Zellweger Spectrum Disorder (ZSD), a rare genetic condition. Researchers will follow 30 participants for five years, performing detailed eye exams and vision tests each year. The goal is to create a time…

This study is testing whether a new smartphone app called 'elleFA' is practical and helpful for women with endometriosis. Twenty participants will use the app for six months to track their symptoms and complete monthly surveys. The main goal is to see if women will consistently u…

This study aims to find out if a simple finger-prick blood spot test can measure inflammation markers as accurately as a traditional blood draw from the arm. Researchers will compare both methods in 50 adults after they experience a planned, temporary stressor like getting a vacc…

This study aims to better understand a group of rare, inherited disorders called peroxisome biogenesis disorders (PBDs). Researchers will follow about 244 patients over time, collecting health records, images, and samples to map out how these diseases progress. The goal is to ide…