Can a simple blood test help ICU doctors use antibiotics wisely?

NCT ID NCT07481773

Recruiting now Knowledge-focused Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a biomarker signature (BV score) can help doctors decide when to use antibiotics for ICU patients. About 1,200 adults in intensive care who started antibiotics within the past 72 hours will be randomly assigned to have their treatment guided by the biomarker plus clinical judgment, or by clinical judgment alone. The goal is to see if the biomarker approach leads to better patient outcomes and less unnecessary antibiotic use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Biomarker-signature supported antibiotic treatment recommendation (diagnostic test)
What this could lead to: If successful, this could help doctors make better antibiotic decisions in ICUs, reducing side effects and antibiotic resistance while improving patient outcomes.
What could go wrong: This is an early-stage study focused on decision-making, not a new drug. The biomarker may not reliably distinguish bacterial from non-bacterial infections, and results may not apply to all ICU patients.

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Conditions

The condition(s) this trial relates to.

disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTENSIVE CARE UNIT (ICU) ADMISSION

Contacts and locations

Locations

Montreal General Hospital
RECRUITING

Montreal, Quebec, H3G 1A4, Canada
Research Institute McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A3J1, Canada
Research Institute of McGill University Health Center (RI-MUHC)
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Royal Victoria Hospital
RECRUITING

Montreal, Quebec, H4A 3J1, Canada

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