Can a common antibiotic stop c. diff from coming back?
NCT ID NCT06979609
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking oral vancomycin while on other antibiotics can prevent a repeat Clostridioides difficile infection (CDI) in people who had one in the last 120 days. Researchers will compare vancomycin to a placebo in 300 adults. Participants take the study drug twice daily during antibiotic treatment and for 7 days after, then are followed for 56 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- vancomycin
- What this could lead to
- If it works, this could provide a simple way to prevent repeat C. diff infections in patients who need other antibiotics.
- What could go wrong
- This is a mid-stage trial, so results are not yet proven. Vancomycin may not reduce recurrence and could contribute to antibiotic resistance.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
McGill University Health Centre
RECRUITINGMontreal, Quebec, H4A3J1, Canada
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