CLOSTRIDIOIDES DIFFICILE INFECTION

This study tests whether taking oral vancomycin while on other antibiotics can prevent a repeat Clostridioides difficile infection (CDI) in people who had one in the last 120 days. Researchers will compare vancomycin to a placebo in 300 adults. Participants take the study drug tw…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis reach remission without steroids. About 85 adults with active UC will receive either fecal transplants or a placebo. The goal is to see if a larger, definitive trial is…

This study tests whether fecal microbiota transplantation (FMT) capsules, made from healthy donor stool, can prevent C. diff infection from coming back better than standard antibiotics. About 100 adults with a first or first-recurrent C. diff infection will get either antibiotics…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

This study tests whether a specific diet can change gut bacteria and help prevent another C. difficile infection in adults who have had one. Twenty participants will receive prepared meals and health counseling, then follow a similar diet for 6 more weeks. Researchers will track …

This study tests EXL01, a single strain of a beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two C. diff episodes will take EXL01 or a placeb…

This study tests an experimental drug called LMN-201 to see if it can prevent C. difficile infection from coming back after standard antibiotic treatment. About 375 adults with a recent C. diff infection will receive either LMN-201 or a placebo. The main goal is to see if more pe…

This study watches 200 adults with C. diff infection to see how standard antibiotics and fecal microbiota transplantation (FMT) help people recover. Researchers will collect stool, blood, and urine samples over up to 5 years to understand why some treatments succeed and others fa…