Poop pills vs antibiotics: new hope for stubborn gut infections?
NCT ID NCT05266807
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether fecal microbiota transplantation (FMT) capsules, made from healthy donor stool, can prevent C. diff infection from coming back better than standard antibiotics. About 100 adults with a first or first-recurrent C. diff infection will get either antibiotics alone or antibiotics followed by FMT capsules. The main goal is to see who stays infection-free for 8 weeks after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Fecal microbiota transplantation (FMT) capsules from healthy donors
What this could lead to
If successful, this could offer a safer, more effective way to prevent C. diff from coming back, reducing the need for repeated antibiotics.
What could go wrong
This is a relatively small Phase 3 trial (100 people), and FMT is still experimental. It may not work better than antibiotics, and there are unknown risks from donor stool.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHUV
RECRUITINGLausanne, Canton of Vaud, 1011, Switzerland
Contact Email: •••••@•••••
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HFR Fribourg - Hôpital cantonal
RECRUITINGFribourg, Canton of Fribourg, 1708, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hirslanden Klinik St Anna
RECRUITINGLucerne, Canton of Lucerne, 6006, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Inselspital Bern
RECRUITINGBern, Canton of Bern, 3010, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut central des hôpitaux
RECRUITINGSion, Valais, 1950, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kantonsspital St Gallen, HOCH
RECRUITINGSankt Gallen, Canton of St. Gallen, 9007, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsspital
RECRUITINGBasel, Basel, 4031, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsspital Zürich
RECRUITINGZurich, Canton of Zurich, 8091, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••