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Poop pills vs antibiotics: new hope for stubborn gut infections?

NCT ID NCT05266807

Recruiting now Disease control Sponsor: Benoit Guery Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether fecal microbiota transplantation (FMT) capsules, made from healthy donor stool, can prevent C. diff infection from coming back better than standard antibiotics. About 100 adults with a first or first-recurrent C. diff infection will get either antibiotics alone or antibiotics followed by FMT capsules. The main goal is to see who stays infection-free for 8 weeks after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Fecal microbiota transplantation (FMT) capsules from healthy donors
What this could lead to
If successful, this could offer a safer, more effective way to prevent C. diff from coming back, reducing the need for repeated antibiotics.
What could go wrong
This is a relatively small Phase 3 trial (100 people), and FMT is still experimental. It may not work better than antibiotics, and there are unknown risks from donor stool.

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis Clostridium infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLOSTRIDIOIDES DIFFICILE INFECTION

Contacts and locations

Locations

  • CHUV

    RECRUITING

    Lausanne, Canton of Vaud, 1011, Switzerland

  • HFR Fribourg - Hôpital cantonal

    RECRUITING

    Fribourg, Canton of Fribourg, 1708, Switzerland

  • Hirslanden Klinik St Anna

    RECRUITING

    Lucerne, Canton of Lucerne, 6006, Switzerland

  • Inselspital Bern

    RECRUITING

    Bern, Canton of Bern, 3010, Switzerland

  • Institut central des hôpitaux

    RECRUITING

    Sion, Valais, 1950, Switzerland

  • Kantonsspital St Gallen, HOCH

    RECRUITING

    Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

  • Universitätsspital

    RECRUITING

    Basel, Basel, 4031, Switzerland

  • Universitätsspital Zürich

    RECRUITING

    Zurich, Canton of Zurich, 8091, Switzerland

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