Could a single friendly gut bacterium prevent recurrent c. diff?

NCT ID NCT06306014

Recruiting now Prevention Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 5 times

Summary

This study tests EXL01, a single strain of a beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two C. diff episodes will take EXL01 or a placebo by mouth. The goal is to see if this treatment is safe and reduces the chance of another infection at 8 weeks.

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis Clostridium infectious disease Reinfection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLOSTRIDIOIDES DIFFICILE INFECTION RECURRENT INFECTION

Contacts and locations

Locations

APHM La Timone Service de Maladies infectieuses
RECRUITING

Marseille, France
CH Annecy Genevois Service de Maladies infectieuses
NOT_YET_RECRUITING

Annecy, France
CHU Grenoble Service Maladies infectieuses et tropicales
RECRUITING

Grenoble, France
CHU Lille Unité des Maladies Infectieuses et tropicales
NOT_YET_RECRUITING

Lille, France
Service d'Hépato-gastroentérologie Hôpital de la Croix Rousse
RECRUITING

Lyon, 69004, France
Service d'hépato-gastroentérologie - CHU Estaing
RECRUITING

Clermont-Ferrand, 63003, France
Service d'hépato-gastroentérologie - Hôpital Saint Antoine (APHP)
RECRUITING

Paris, 75012, France
Service d'infectiologie - Hôpital Nord / CHU Saint Etienne
RECRUITING

Saint-Etienne, 42100, France
Service de Maladies Infectieuses - CH de Valence
RECRUITING

Valence, 26000, France
Service de médecine interne - Pôle des maladies de l'appareil digestif - CHU de Toulouse
RECRUITING

Toulouse, 31059, France

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