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Surgery or more drugs? new study aims to guide tough UC decisions

NCT ID NCT07347834

Recruiting now Disease control Sponsor: Region Stockholm Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 500 people with ulcerative colitis who have already tried at least two advanced medications without success. Participants choose either to continue trying different medications or to have their colon removed (colectomy). Researchers will compare quality of life, bowel function, and satisfaction between the two groups over six months. The goal is to provide clearer guidance for future patients facing this difficult choice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
advanced medical therapy (biologics or small molecules) vs. colectomy surgery
What this could lead to
If successful, this study could help doctors and patients make better-informed decisions about whether to keep trying new medications or opt for surgery after multiple treatment failures.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by patient choice. It does not test a new drug or procedure, and outcomes depend on many individual factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS (UC)

Contacts and locations

Locations

  • Karolinska University Hospital

    RECRUITING

    Solna, Stockholm County, 17176, Sweden

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