New procedure aims to stop debilitating headaches from spinal fluid leaks
NCT ID NCT05922514
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a procedure called transvenous embolization to treat spontaneous intracranial hypotension, a condition where spinal fluid leaks cause severe headaches. Researchers at Mayo Clinic will enroll 200 people with confirmed CSF-venous fistulas. The goal is to see if blocking the leak with an embolic agent can reduce headache impact and improve MRI findings.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Transvenous embolization of cerebrospinal fluid-venous fistula
What this could lead to
If this procedure works, it could point toward a standard treatment for spontaneous intracranial hypotension caused by CSF-venous fistulas, potentially relieving severe headaches.
What could go wrong
This is an early registry study with only 200 participants, so results may not apply to everyone. The procedure involves risks like bleeding or infection, and it may not fully resolve symptoms.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic Minnesota
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••