New procedure aims to stop debilitating headaches from spinal fluid leaks

NCT ID NCT05922514

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study tests a procedure called transvenous embolization to treat spontaneous intracranial hypotension, a condition where spinal fluid leaks cause severe headaches. Researchers at Mayo Clinic will enroll 200 people with confirmed CSF-venous fistulas. The goal is to see if blocking the leak with an embolic agent can reduce headache impact and improve MRI findings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transvenous embolization of cerebrospinal fluid-venous fistula
What this could lead to: If this procedure works, it could point toward a standard treatment for spontaneous intracranial hypotension caused by CSF-venous fistulas, potentially relieving severe headaches.
What could go wrong: This is an early registry study with only 200 participants, so results may not apply to everyone. The procedure involves risks like bleeding or infection, and it may not fully resolve symptoms.

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Conditions

The condition(s) this trial relates to.

intracranial hypotension spontaneous intracranial hypotension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPONTANEOUS INTRACRANIAL HYPOTENSION

Contacts and locations

Locations

Mayo Clinic Minnesota
RECRUITING

Rochester, Minnesota, 55905, United States

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