Intracranial hypotension

This study tests a procedure called transvenous embolization to treat spontaneous intracranial hypotension, a condition where spinal fluid leaks cause severe headaches. Researchers at Mayo Clinic will enroll 200 people with confirmed CSF-venous fistulas. The goal is to see if blo…

This study compares two types of CT myelography scans to detect CSF-venous fistulas, abnormal connections that cause spinal fluid leaks, in 200 adults with spontaneous intracranial hypotension (low-pressure headaches). Participants will be randomly assigned to receive either a ne…

This study compares two inhaled treatments—neostigmine/atropine versus lidocaine—for severe headaches that can occur after spinal anesthesia during C-sections. About 111 women aged 18-35 with moderate to severe headache will be randomly assigned to one of the two treatments. The …

This study tests two inhaled medicines—dexmedetomidine and lidocaine—to treat severe headaches that can happen after spinal anesthesia during planned C-sections. About 114 women with moderate to severe headaches will receive one of the treatments through a nebulizer (a machine th…

This study compares three medications—theophylline, sumatriptan, and gabapentin—to see which works best for post-dural puncture headache, a severe headache that can occur after a spinal tap or epidural. Researchers will enroll 75 adults aged 21 to 50 who have this type of headach…

This pilot study tests whether two drugs, neostigmine and glycopyrrolate, can treat severe headaches that sometimes occur after an epidural needle accidentally punctures the spinal lining during labor. The study will enroll 18 postpartum women with this type of headache. The goal…

This study tests whether giving less or more IV fluids during a planned C-section helps reduce nausea and vomiting after surgery and helps the bowels recover faster. About 160 women having planned C-sections under spinal anesthesia will take part. The goal is to find the best flu…

This study tests whether drinking coffee after a cesarean section can reduce the chance of a spinal headache (postdural puncture headache) and the need for painkillers. About 82 women who had a C-section under spinal anesthesia will drink coffee four times over two days. Research…

This study tests a nerve block (sphenopalatine ganglion block) against the standard blood patch for treating severe headaches that can happen after a spinal tap or epidural. The nerve block is less invasive and involves numbing the nose. The trial will enroll 80 adults and measur…

This study looks at whether a nerve block in the back of the head can temporarily relieve severe headaches caused by a spinal fluid leak. About 34 adults with this condition will receive the injection and be monitored for pain changes. The goal is to provide a safe, accessible br…

This study will follow 292 women having C-sections with spinal anesthesia to see if those living at high altitudes get more post-dural puncture headaches than those at low altitudes. Researchers will track headache severity and compare groups. The goal is to understand if altitud…