Intracranial hypotension
MONDO:0006811Reduction of cerebrospinal fluid pressure characterized clinically by headache which is maximal in an upright posture and occasionally by an abducens nerve palsy (see abducens nerve diseases), neck stiffness, hearing loss (see deafness); nausea; and other symptoms. This condition may be spontaneous or secondary to spinal puncture; neurosurgical procedures; dehydration; uremia; trauma (see also craniocerebral trauma); and other processes. Chronic hypotension may be associated with subdural hematomas (see hematoma, subdural) or hygromas. (From Semin Neurol 1996 Mar;16(1):5-10; Adams et al., Principles of Neurology, 6th ed, pp637-8)
32 clinical trials for this condition and its sub-types.
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Withdrawn study on plasma patches for rare headaches leaves questions unanswered
Disease control TerminatedThis study planned to compare two methods of delivering a platelet-rich plasma patch to treat headaches caused by low spinal fluid pressure. The trial was withdrawn before any participants were enrolled, so no data was collected. The goal was to see if a simpler blind approach co…
Phase: NA • Sponsor: Beijing Tiantan Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Nerve block may ease debilitating headaches after childbirth epidurals
Symptom relief TerminatedThis study tests whether a sphenopalatine ganglion block (SPGB) using lidocaine can reduce the severity and duration of post-dural puncture headache (PDPH) in new mothers. PDPH is a severe headache that can occur after an epidural or spinal needle insertion for labor pain relief.…
Phase: NA • Sponsor: McMaster University • Aim: Symptom relief
Last updated Jul 09, 2026 00:00 UTC
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Magnesium may stop Post-Spinal headaches in new moms
Symptom relief OngoingThis study will review the medical records of 300 women who had a planned C-section under spinal anesthesia. Researchers want to see if those who received magnesium had fewer headaches afterward. The goal is to find a simple way to prevent this common side effect.
Sponsor: Haseki Training and Research Hospital • Aim: Symptom relief
Last updated Jul 09, 2026 00:00 UTC
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Leg workouts may stop spinal headaches after C-Section
Symptom relief OngoingThis study tests whether doing simple leg exercises after spinal anesthesia for a C-section can help reduce headaches and improve heart function. 120 women aged 18-40 will perform supervised isometric exercises during recovery. The goal is to find a safe, non-drug way to manage p…
Phase: NA • Sponsor: Karbala University • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC