New nerve block could replace needle in the back for spinal headaches

NCT ID NCT07354464

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a nerve block (sphenopalatine ganglion block) against the standard blood patch for treating severe headaches that can happen after a spinal tap or epidural. The nerve block is less invasive and involves numbing the nose. The trial will enroll 80 adults and measure pain relief over a week.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

lidocaine (nerve block)

What this could lead to

If it works, this could offer a simpler, less invasive treatment for severe headaches after spinal procedures, reducing the need for the more invasive blood patch.

What could go wrong

This is a relatively small Phase 3 trial (80 people). The nerve block may not be as effective as the blood patch, or its pain relief may not last as long.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

intracranial hypotension Post-Dural Puncture Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • CHU de Clermont-Ferrand

    RECRUITING

    Clermont-Ferrand, France

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••