New drug combo may ease Post-Epidural headaches in new moms

NCT ID NCT05116930

Recruiting now Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether two drugs, neostigmine and glycopyrrolate, can treat severe headaches that sometimes occur after an epidural needle accidentally punctures the spinal lining during labor. The study will enroll 18 postpartum women with this type of headache. The goal is to see if the drugs reduce the need for a standard treatment called an epidural blood patch.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Neostigmine and glycopyrrolate (drugs given through an IV)
What this could lead to: If it works, this could offer a new, less invasive way to treat severe headaches after epidural placement in labor, potentially avoiding a more invasive procedure.
What could go wrong: This is a very small pilot study with only 18 participants, so results may not apply widely. The drugs can cause side effects like nausea or heart rhythm changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intracranial hypotension Post-Dural Puncture Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-DURAL PUNCTURE HEADACHE

Contacts and locations

Locations

Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States

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