New nasal spray could ease Kids' migraines

NCT ID NCT06995729

Recruiting now Symptom relief Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study is testing a nasal spray called zavegepant in 16 children aged 6 to 12 who have had migraines for at least 6 months. The main goal is to see if the drug is safe and how the body handles it. Each child gets a single dose based on their weight, and the study lasts up to 10 weeks with 3 clinic visits and 2 phone calls.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zavegepant (nasal spray)
What this could lead to: If this works, it could point toward a fast-acting migraine treatment option for children.
What could go wrong: This is a very early Phase 1 trial with only 16 children, so it is primarily checking safety, not whether the drug actually stops migraines. The results may not lead to a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE TREATMENT OF MIGRAINE

Contacts and locations

Locations

Accellacare - Piedmont
RECRUITING

Statesville, North Carolina, 28625, United States
Accellacare US Inc.
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Accellacare of Piedmont HealthCare
RECRUITING

Statesville, North Carolina, 28625, United States
Arkansas Children's Hospital
NOT_YET_RECRUITING

Little Rock, Arkansas, 72202, United States
Cedar Health Research
RECRUITING

Dallas, Texas, 75251, United States
Central States Research
RECRUITING

Tulsa, Oklahoma, 74136, United States
Children's Hospital & Medical Center
RECRUITING

Omaha, Nebraska, 68114, United States
Clinical Research Institute
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55402, United States
Coastal Heritage Clinical Research
RECRUITING

Hinesville, Georgia, 31313, United States
Granger Medical Holladay - Holladay Clinic
RECRUITING

Salt Lake City, Utah, 84117, United States
True North Neurology
NOT_YET_RECRUITING

Port Jefferson Station, New York, 11776, United States
Velocity Clinical Research, Washington DC
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20016, United States
Wasatch Clinical Research, LLC
RECRUITING

Salt Lake City, Utah, 84107, United States

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