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Scientists probe shared pain pathways in endometriosis and migraine

NCT ID NCT06785129

Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates why endometriosis and migraine often occur together. Researchers will measure pain sensitivity and sex hormone levels in four groups: people with endometriosis, people with migraine, people with both conditions, and healthy controls. Participants complete surveys, undergo pain tests using heat, cold, and pressure, and provide blood samples. The goal is to uncover shared mechanisms that could inform future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal shared biological mechanisms linking endometriosis and migraine, potentially pointing toward new treatment targets.
What could go wrong
This is an observational study, not a treatment trial. It may not identify clear differences, and findings may not lead directly to therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

participants with migraine OR with endometriosis OR with migraine and endometriosis OR with no chronic pain condition

Ages

12 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with diagnosed endometriosis, migraine, or both endometriosis and migraine 2. Healthy control subjects with no history of chronic pain 3. Age 12-45 4. Assigned female sex at birth Exclusion Criteria: 1. Pregnancy or breastfeeding 2. Presence of prolactinoma 3. Presence of psychiatric, neurological, endocrinological and/or developmental conditions and taking medications for these conditions 4. Current use of dopamine agonist or SSRI medications 5. For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health

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Conditions

The condition(s) this trial relates to.

endometriosis migraine disorder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis Migraine

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

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