ENDOMETRIOSIS

This study tests whether a new capsule called Indinol Forto works as well as the standard tablet Visanne for reducing pelvic pain caused by endometriosis. About 290 women aged 18 to 45 who have been diagnosed with endometriosis through surgery will take either the new capsule or …

This study tests whether a gentler surgical technique using argon plasma can better protect the ovaries compared to the standard cystectomy for ovarian endometriomas. Seventy-two women with endometriosis will be randomly assigned to one of the two procedures. The main goal is to …

This study tests whether a special nutritional drink taken before bladder removal surgery (cystectomy) can lower the risk of infections and other complications. About 232 adults with various bladder conditions will be randomly assigned to receive the drink or standard care. The m…

This study is testing a new robotic surgery system (Medtronic Hugo™) to see if it is safe and works well for hysterectomy. About 70 adult women with conditions like fibroids, endometriosis, or certain cancers will take part. The main goal is to see if the surgery can be completed…

This study looks at whether having surgery to remove endometriosis from the bowel before IVF helps women with infertility get pregnant. About 120 women with painful, deep endometriosis will be randomly assigned to either surgery plus IVF or IVF alone. The main goal is to see whic…

This study is for women under 39 with advanced endometriosis (stage III-IV) who want to get pregnant. It compares two approaches: having surgery to remove endometriosis tissue before trying IVF, or going straight to IVF without surgery. The goal is to see which method leads to mo…

This study is testing a new blood test called HerResolve™ to see if it can accurately detect endometriosis in women aged 18 to 49 who have symptoms like pelvic pain or abnormal bleeding. Currently, diagnosis often requires a surgical procedure called laparoscopy. The study will c…

This study looks for signs of endometriosis in menstrual blood, which is easy to collect. Researchers will compare samples from 250 women with and without the condition, and also check if these signs change after surgery. The goal is to create a simple, non-invasive test to diagn…

This study tests whether a special PET scan (18F-FES) can find endometriosis lesions more accurately than MRI. It will involve 20 women having surgery for endometriosis, some with high pain and some with low pain. The scan measures estrogen receptor activity, which may help docto…

This study is testing whether a special type of PET/MRI scan can accurately diagnose endometriosis. Researchers will enroll 24 women who are suspected of having the condition. The goal is to see if this imaging method can detect endometriosis without needing surgery, potentially …

This study looks at whether a protein called L-PGDS, found in blood, urine, and vaginal samples, can help diagnose adenomyosis. Adenomyosis is a painful condition where the uterine lining grows into the muscle wall, and diagnosis often requires surgery. Researchers will compare L…

This study compares two types of radiation therapy—proton therapy and standard IMRT—given after surgery for endometrial or cervical cancer. The goal is to see which one causes fewer bowel and bladder side effects. About 120 people who have had a hysterectomy for these cancers wil…

This study compares two types of surgery—robot-assisted and standard laparoscopic—for removing the uterus in people with deep endometriosis. The goal is to see which method leads to fewer complications and better quality of life. About 224 adults will take part, and the results c…

This study tests whether practicing yoga can reduce pain in women with endometriosis. About 30 women aged 18-45 who have had surgery-confirmed endometriosis and moderate pain will participate. They will do yoga sessions and report their pain levels using questionnaires. The goal …

This study looks at whether dietary guidance and probiotics can help reduce chronic pelvic pain in women who have both endometriosis and irritable bowel syndrome (IBS). About 74 women aged 18 to 50 will be randomly assigned to different treatment groups to see if these approaches…

This study tests a new drug called vipoglanstat to see if it can reduce pelvic pain in women with endometriosis. About 190 women with moderate to severe pain will receive either the drug or a placebo for four months. The goal is to find a better treatment option for this painful …

This study tests whether a single, short mindfulness session before endometriosis surgery can help reduce pain and the need for painkillers afterward. About 20 adults with endometriosis will either receive the mindfulness training or standard education before their operation. Res…

This study tests whether using a special dye to see the ureters during endometriosis surgery causes less pain than the usual plastic stents. About 70 women with deep endometriosis will take part. The goal is to see if this approach is practical and acceptable before a larger tria…

This study tests if a gentle, non-invasive nerve stimulation device placed on the ear can reduce chronic pelvic pain in women with endometriosis. The treatment aims to calm pain signals and inflammation without surgery or drugs. 72 women aged 15 and older with diagnosed endometri…

This study tests a TENS device, which uses mild electrical pulses, to reduce pelvic pain in women with endometriosis or adenomyosis. About 92 women on stable hormone therapy will use either an active or a sham (inactive) device for 4 weeks, then everyone gets the active device fo…

This study compares a home pelvic floor physical therapy program to standard post-surgery care for 30 women having endometriosis excision (without hysterectomy). The goal is to see if the home program improves pelvic pain, bladder/bowel symptoms, and overall quality of life durin…

This study tests an 8-week group program called PEEPS for women aged 18-48 with endometriosis-related chronic pelvic pain. Participants join weekly group sessions and complete surveys about pain and quality of life. The goal is to see if the program reduces how much pain interfer…

This study tests whether metformin, a diabetes drug, can reduce pelvic pain in young women with endometriosis. Fourteen participants will take either metformin or a placebo daily for 6 months and track their symptoms. The goal is to see if this non-hormonal approach offers pain r…

This study tests if an internet-based therapy called Acceptance and Commitment Therapy (ACT) can help people with endometriosis manage chronic pain and improve daily functioning. Ten participants will receive online sessions focusing on pain education, mindfulness, and behavior c…

This study tests whether a whole food plant-based diet can reduce pain in women with endometriosis. 120 participants will either follow the special diet or their usual diet for 12 weeks. The goal is to see if changing what you eat can ease pelvic pain.

This study looks at whether giving a GnRH agonist hormone injection before a frozen embryo transfer can help women with endometriosis or adenomyosis get pregnant. About 180 women aged 18 to 36 will be randomly assigned to receive either the hormone plus standard estrogen/progesti…

This study tests whether a low-fat plant-based diet can reduce pain and improve quality of life in women with endometriosis. 120 women aged 18-45 with confirmed endometriosis and moderate to severe pain will be randomly assigned to either follow the diet for 12 weeks or stick wit…

This study tests whether a program of educational workshops and regular nurse phone calls can improve quality of life for women with endometriosis. About 260 women with confirmed endometriosis and chronic pelvic pain will take part. The program is designed to help patients better…

This study tests whether a special 'good pain consultation' that includes education about pain from a biopsychosocial perspective can help women with endometriosis feel more in control of their pain and improve their quality of life. About 110 women will either receive this consu…

This study tests whether live, online yoga classes (Tele-Yoga) can help women with endometriosis feel less pelvic pain and fatigue and improve their quality of life. About 66 women who do not currently exercise will be randomly assigned to either Tele-Yoga or their usual care. Re…

This study tests a custom, hemp-derived CBD product against a placebo to see if it can reduce pain and improve quality of life in people with endometriosis. Researchers will track pain levels and other symptoms over 12 weeks. The goal is to provide much-needed evidence on whether…

This study looks at whether combining pain education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. Researchers will track how well participants stick with the program and any side effects like incr…

This study checks if a non-surgical treatment called HIFU (high-intensity focused ultrasound) provides lasting benefits for people with rectal endometriosis. Researchers will compare quality-of-life scores before and years after treatment. About 140 participants who previously ha…

This study tests a wearable device called NettleEndo that uses gentle brain stimulation to reduce chronic pelvic pain in women with endometriosis. 120 participants will use the device at home for 20 minutes a day, five times a week for 12 weeks. Half will get real stimulation, ha…

This study tests a smartphone app called Lyv Endo designed to help women with endometriosis manage their condition. The goal is to see if using the app improves quality of life and reduces symptom severity. The study will enroll 304 women with confirmed endometriosis who have mod…

This study looks at whether a simple, noninvasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare retinal images from 100 women with and without the condition. The goal is to see if the eyes can provide a new way to monitor the dise…

This study follows 650 women with endometriosis who want to have children after treatment. It compares pregnancy rates and use of fertility treatments between those who had medical therapy versus surgery. The goal is to help doctors and patients make better-informed decisions abo…

This study looks at whether removing deep endometriosis tissue from the pelvis affects a woman's egg supply. Researchers will measure a hormone called AMH before and 12 months after surgery in 100 women aged 18 to 39. The goal is to help doctors decide if women should consider fr…

This study looks at 40 women to see if a simple body measurement (anogenital distance) and hormone levels differ between those with severe endometriosis and those without. Participants provide blood and saliva samples before and after watching an empathy-triggering video. The goa…

This study looks at how well pelvic organs move in women with endometriosis using dynamic MRI. Researchers want to see if measuring organ movement can help diagnose the disease better and explain why some treatments don't work. About 52 women with suspected endometriosis will tak…

This study looks at why migraine is more common in people with autoimmune diseases like multiple sclerosis or rheumatoid arthritis. Researchers will measure immune cells and inflammatory markers in 396 women with and without migraine, including those with autoimmune conditions. T…

This study looks at how pesticides and the balance of bacteria in the gut and reproductive tract may affect infertility in women with endometriosis. Researchers will compare 160 women with and without endometriosis to find patterns that could lead to earlier diagnosis. The goal i…

This study follows 15,000 women with endometriosis over 10 years to see how well different treatments—medication or surgery—work in the long run. Researchers track pain, quality of life, disease return, and pregnancy rates. The goal is to learn which approaches help most, so doct…

This study looks at whether a medication that temporarily stops menstruation (like a short-term menopause) can reduce fat buildup in the liver of women with endometriosis. About 62 women will receive the drug goserelin acetate, and researchers will measure changes in liver fat an…

This study is creating a national registry to collect information from 300 people with parietal endometriosis, a condition where endometriosis tissue grows in the abdominal wall. The goal is to track how well two treatments—surgery and a freezing technique called cryoablation—wor…

This study follows 200 adult women who visit the gynecological emergency department for endometriosis or symptoms like pelvic pain. Researchers will track whether patients receive proper treatments, specialist referrals, and imaging tests as recommended by guidelines. The goal is…

This study examines how different ovarian stimulation protocols affect blood clotting and clot breakdown in infertile women. Researchers will compare various stimulation methods to see how they influence thrombin formation and fibrinolysis. The study includes 300 women diagnosed …

This study follows 5,300 women with endometriosis or adenomyosis to see if these conditions get worse over time. Researchers will track pain, bleeding, and fertility, and also study immune system and gut bacteria. The goal is to better understand these diseases, not to test a new…

This study aims to understand how a hormone-suppressing drug (Relugolix Combination Therapy) affects pelvic pain, inflammation, and pain sensitivity in women with moderate-to-severe endometriosis. Researchers will measure changes in blood markers and brain activity to see how the…

This study aims to see if brain imaging can predict which women with severe endometriosis will have less pain after surgery. Researchers will scan the brains of 100 women before their operation and check their pain levels a year later. The goal is to better understand who benefit…

This study aims to collect detailed information from 1000 people in the UK who have endometriosis, a chronic pain condition affecting 1 in 10 women. Participants will use a mobile app to track symptoms, provide biological samples, and wear a smartwatch. The goal is to find better…

This study tests a new surgical device called CUSA Clarity that uses ultrasound to selectively remove endometriotic cysts from the ovary while leaving healthy tissue intact. Researchers will examine cyst wall samples from 10 women to see if the device can spare ovarian tissue, wh…

This study looks at how the womb absorbs fluid during early pregnancy, which may affect fertility. Researchers will take small tissue samples from the womb lining of 140 women, some with endometriosis and some without. The goal is to understand differences in key proteins that co…

This study is collecting health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to better understand these illnesses and help…

This study looks at endometriosis and adenomyosis, two chronic conditions that affect women's reproductive health. Researchers will collect blood and fluid samples from 530 women to study genes, epigenetics, and ultrasound images, using AI to find better ways to diagnose these co…

This study aims to create a realistic model of the endometrium (the uterine lining) in the lab using tissue from patient biopsies. Researchers will test how different hormone treatments affect this model, with the goal of predicting which treatment works best for each person. The…

This study tests whether a new smartphone app called elleFA can help women with endometriosis track their symptoms and communicate better with their healthcare team. About 20 pre-menopausal women aged 18 and older with known or suspected endometriosis will use the app for 6 month…