ENDOMETRIOSIS

This study aims to find the best first step for women with advanced endometriosis who want to get pregnant. It will compare two common approaches: having surgery to remove endometriosis tissue before starting IVF fertility treatment, or starting IVF treatment right away. The main…

This study compares two surgical approaches for removing the uterus in patients with severe endometriosis and adenomyosis. Researchers want to see if using a robot-assisted system leads to fewer complications during and after surgery compared to standard laparoscopic (keyhole) su…

This study is testing whether a new medication called Indinol Forto works as well as an established treatment (Visanne) for reducing pelvic pain caused by endometriosis. Researchers will enroll 290 women aged 18-45 who have been surgically diagnosed with endometriosis and experie…

This study checks how well a focused ultrasound treatment works over the long term for people with rectal endometriosis, a condition where uterine-like tissue grows in the bowel wall causing pain. Researchers are following up with 140 patients who previously received this non-inv…

This study is testing if adding a hormone injection (GnRH agonist) to the standard medication before a frozen embryo transfer can help women with endometriosis or adenomyosis get pregnant. Researchers will compare pregnancy rates between women who receive the extra injection and …

This study is testing whether drinking special nutritional supplements before bladder removal surgery helps patients recover with fewer complications. Researchers will compare patients who receive the supplements to those who do not, looking at infection rates and overall recover…

This study aims to find out if having complete surgery to remove colorectal endometriosis before starting IVF treatment leads to better pregnancy rates compared to starting IVF treatment alone. It will involve 120 women with this specific type of endometriosis who are struggling …

This study is testing a new surgical tool called CUSA Clarity to see if it can remove endometriosis tissue from ovarian cysts while leaving healthy ovary tissue behind. Researchers will examine tissue samples from 10 women after surgery to see if the tool works as intended. The g…

This study is testing if metformin, a common diabetes medication, can help reduce pelvic pain in young women with endometriosis when used alongside their regular hormone therapy. Researchers will compare metformin to a placebo (sugar pill) over six months in 14 participants to se…

This study is evaluating the safety and performance of the Medtronic Hugo robotic surgery system when used to perform hysterectomies. It will enroll about 70 adult women who need this surgery for various conditions, including fibroids, endometriosis, and certain cancers. The main…

This study aims to understand how a hormone-suppressing medication called Relugolix Combination Therapy affects pelvic pain in women with moderate-to-severe endometriosis. Researchers will measure changes in pain levels, inflammation, and brain activity using MRI scans and blood …

This study compares two surgical approaches for removing endometriosis cysts from ovaries. Researchers want to see if a newer method using argon plasma (APC) is better at preserving ovarian reserve—a measure of future fertility potential—than the standard surgical removal (cystec…

This study is testing a new type of PET scan to see if it can better detect and characterize endometriosis lesions compared to a standard MRI. Researchers will enroll 20 people with endometriosis who are scheduled for surgery. The main goal is to see if the scan results can be li…

This study aims to improve the diagnosis of endometriosis by using a special type of MRI scan that measures how much pelvic organs move when a woman pushes. Researchers will scan 52 women with suspected endometriosis to see if reduced organ mobility is linked to common symptoms l…

This study aims to develop better ways to diagnose endometriosis and adenomyosis, two chronic conditions that affect women's reproductive health. Researchers will analyze blood samples, genetic information, and ultrasound images from 530 women, using artificial intelligence to fi…

This study is testing a new type of PET/MRI scan to see if it can better detect endometriosis, a painful condition where tissue similar to the uterine lining grows outside the uterus. Researchers will enroll 24 women who have symptoms and are scheduled for surgery to see how accu…

This study is testing a new blood test called HerResolve™ that aims to detect endometriosis without surgery. Researchers will compare the blood test results to findings from laparoscopic surgery in 100 women aged 18-49 who have pelvic pain symptoms. The goal is to see if this non…

This study aims to find a better way to diagnose adenomyosis, a painful condition where uterine tissue grows into the muscle wall. Researchers will measure levels of a protein called L-PGDS in blood, urine, and tissue samples from 60 women to see if it can serve as a reliable mar…

This study is testing whether a home physical therapy program helps people recover better from endometriosis surgery. Researchers will compare patients doing guided home exercises after surgery to those receiving standard post-op care. The goal is to see if the exercises improve …

This small pilot study is testing an online therapy program designed to help women with endometriosis manage their chronic pain. Ten participants will work through a guided program focused on mindfulness, acceptance, and changing behaviors related to pain. The goal is to see if t…

This study is testing whether a special educational program can improve the quality of life for women living with endometriosis. The program involves group workshops led by different health professionals and regular check-in phone calls from a nurse. Researchers will compare the …

This small pilot study is testing whether a single, brief mindfulness session before surgery can help people with endometriosis. The goal is to see if learning mindfulness techniques is practical for patients and if it might help them cope with stress and pain after their operati…

This study is testing whether a new drug called vipoglanstat can safely reduce the chronic pelvic pain experienced by people with endometriosis. It will involve about 190 premenopausal women with moderate to severe pain. Participants will be randomly assigned to receive either th…

This study compares two types of radiation therapy given after surgery for cervical or endometrial cancer to see which causes fewer short-term side effects. Researchers want to know if proton radiation causes less bowel and bladder irritation than standard intensity-modulated rad…

This pilot study is testing if using a special green dye to see the urinary tubes during endometriosis surgery causes less pain afterward than the standard method of placing temporary plastic tubes (stents). It involves 70 women in the UK who are scheduled for deep endometriosis …

This study is testing whether a smartphone app called Lyv Endo can help improve the quality of life for women with endometriosis. The app provides personalized support and education on topics like pain, mental health, nutrition, and exercise. Researchers will enroll 304 women to …

This study is testing whether a program of yoga delivered online (Tele-Yoga) can help women with endometriosis manage their chronic pelvic pain and fatigue, and improve their quality of life. Researchers will compare the experiences of women who do the yoga program to those who d…

This study is testing a non-invasive device that delivers gentle electrical stimulation to a nerve in the ear. The goal is to see if this stimulation can reduce chronic pelvic pain in women with endometriosis, a condition where tissue similar to the uterine lining grows outside t…

This study is testing whether an 8-week group support program helps women with chronic pelvic pain from endometriosis. It compares the group program, which includes yoga and peer support, to standard educational materials. Researchers want to see which approach better helps parti…

This study is testing whether a combination of pain education and a tailored exercise program can help reduce pain, improve quality of life, and change negative thought patterns in women with endometriosis. Researchers at the University of Seville are enrolling 32 adult women dia…

This study is testing whether a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve mood and sleep in women with endometriosis. Participants will use the device at home for 20 minutes, five times a week for 12 weeks, with half receiving …

This study is testing whether following a low-fat, plant-based diet for 12 weeks can help reduce pain and improve quality of life for women with endometriosis. Researchers will compare 120 women who either follow this special diet or continue their usual eating habits. The main g…

This study is testing whether following specific dietary advice and taking probiotics can help reduce chronic pelvic pain in women who have both endometriosis and irritable bowel syndrome (IBS). Researchers will compare pain levels and quality of life in 74 participants who recei…

This study is testing whether a 12-week yoga program can help reduce pain for women with endometriosis. Researchers are recruiting 30 women with moderate pain to participate in online yoga sessions. The goal is to see if yoga, as a complementary therapy, improves pain scores and …

This study aims to predict which patients with severe endometriosis will get lasting pain relief from surgery. Researchers will use brain scans and other tests before surgery to see if they can forecast the 12-month pain outcome. The goal is to help patients and doctors make bett…

This study aims to understand how the uterus absorbs fluid during early pregnancy by comparing tissue samples from women with and without endometriosis. Researchers will analyze specific proteins in uterine tissue collected from 140 participants across their menstrual cycles. The…

This study aims to better understand what causes migraine by investigating the immune system. Researchers will compare levels of specific immune cells and inflammatory signals in women with and without migraine, some of whom also have other autoimmune conditions. The goal is to g…

This study aims to understand if a drug that temporarily stops menstrual cycles (causing a reversible, drug-induced menopause) affects fat buildup in the liver. It will observe 62 women with endometriosis, comparing those who receive the drug after surgery to those who do not. Th…

This study is exploring whether a quick, non-invasive eye scan can detect body-wide inflammation in people with endometriosis. Researchers will compare detailed images of the back of the eye from 100 women—some with endometriosis and some without—to see if the scans show measurab…

This study aims to understand if surgery to remove severe deep endometriosis from the pelvis affects a woman's ovarian reserve, which is an indicator of her remaining egg supply and fertility potential. Researchers will compare hormone levels in 100 women aged 18-39 who have this…

This Italian study observes women with endometriosis who want to have children. Researchers will compare pregnancy rates and live births between those who received medication versus surgery for their endometriosis. The goal is to understand which treatment approach might lead to …

This study aims to create a detailed lab model using tissue donated by patients with and without endometriosis. The goal is to better understand the disease and see how this lab-grown tissue responds to different hormonal treatments. This could one day help doctors predict which …

This study aims to understand how endometriosis and adenomyosis change over time, including pain levels, bleeding, and infertility. It will follow 5,300 women to see if the diseases get worse and to look for biological clues in blood and tissue samples. The goal is to find better…

This study aims to understand how pesticide exposure might be linked to endometriosis, a painful condition that can cause infertility. Researchers will compare 160 women with and without endometriosis, measuring stress markers in their blood and analyzing the bacteria in their gu…

This study aims to understand if different fertility drug protocols affect blood clotting in women undergoing infertility treatment. Researchers will measure clotting factors in 300 women before and after their fertility medication cycles. The goal is to see if certain treatment …

This study is testing whether a new smartphone app called 'elleFA' is practical and helpful for women with endometriosis. Twenty participants will use the app for six months to track their symptoms and complete monthly surveys. The main goal is to see if women will consistently u…

This large UK study aims to gather detailed information to improve the diagnosis and future treatment of endometriosis. It will follow 1000 women with the condition for two years, collecting data on their symptoms, lifestyle, and biological samples. The goal is to find patterns a…

This study is creating a national registry to track and compare two treatments for abdominal wall endometriosis: surgical removal and a freezing procedure called cryoablation. It will follow 300 patients for three years to see which treatment works better, has fewer complications…

This is a long-term research project gathering health information from 10,000 people in the U.S. to build a detailed picture of brain inflammation and related conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants, including both affected and healthy individual…

This study aims to understand what happens to patients after they visit a gynecological emergency department for endometriosis or its painful symptoms. Researchers will follow 200 adult patients for three months to see what treatments they receive and what specialist care they ac…

This study aims to understand which endometriosis treatments work best over the long run. It will follow 15,000 women with confirmed endometriosis for up to 10 years, tracking their pain, quality of life, and pregnancy outcomes. The goal is to gather real-world evidence on how we…

This study aims to better understand the potential early-life origins of endometriosis, a painful condition affecting 1 in 10 women. Researchers will compare two small groups of women—one with confirmed endometriosis and one without—by measuring a specific physical distance and c…