New hope for endometriosis? Plant-Based pill takes on hormone therapy

NCT ID NCT07164183

Recruiting now Disease control Sponsor: Alcea Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether a plant-based supplement (Indinol Forto, made from indole-3-carbinol) works as well as a standard hormone drug (Visanne, dienogest) for reducing pelvic pain in endometriosis. About 290 women aged 18-45 with surgically confirmed endometriosis will take one of the two treatments for 24 weeks. The main goal is to see if pain scores improve similarly in both groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Indinol Forto (indole-3-carbinol) and Visanne (dienogest)
What this could lead to: If successful, this could offer a new non-hormonal option for managing endometriosis pain, potentially with fewer side effects than current hormone therapies.
What could go wrong: This is a non-inferiority trial, so it may only show that Indinol Forto is no worse than Visanne, not necessarily better. The open-label design (no placebo) could bias results, and the study is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometriosis Pelvic Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOSIS

Contacts and locations

Locations

Research Site
NOT_YET_RECRUITING

Kazan', Russia
Research Site
NOT_YET_RECRUITING

Moscow, Russia
Research Site
NOT_YET_RECRUITING

Rostov-on-Don, Russia
Research Site
RECRUITING

Ryazan, Russia
Research Site
NOT_YET_RECRUITING

Saint Petersburg, Russia
Research Site
RECRUITING

Smolensk, Russia
Research Site
NOT_YET_RECRUITING

Tver', Russia
Research Site
RECRUITING

Yaroslavl, Russia

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