Can a daily pill after endometriosis surgery keep pain away?
NCT ID NCT06439524
First seen Jun 13, 2026 · Last updated Jun 23, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether taking Relugolix combination therapy (Rel-CT) right after endometriosis surgery leads to better quality of life and less chance of the disease coming back. About 110 women having laparoscopic or robotic surgery for endometriosis will be randomly assigned to either take Rel-CT daily for 6 months after surgery or have surgery alone. Researchers will compare changes in a 30-question health survey at 1, 3, and 6 months after surgery.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Main Line Health
RECRUITINGWynnewood, Pennsylvania, 19096, United States
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Relugolix combination therapy (Rel-CT) – a daily tablet containing relugolix, estradiol, and norethindrone acetate
What this could lead to
If it works, this could show that starting Rel-CT right after surgery improves quality of life and lowers the chance endometriosis comes back, possibly reducing the need for repeat surgery.
What could go wrong
This is a single-site trial with 110 participants, so results may not apply to everyone. Rel-CT has side effects like blood clot risk and bone thinning, and it requires ongoing medication, not a one-time fix.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.