ENDOMETRIOSIS

This study tests a less invasive surgery called laparoscopic sclerotherapy for ovarian cysts (endometriomas) caused by endometriosis. The goal is to see if this method better protects a woman's egg supply (ovarian reserve) compared to standard cyst removal. Twenty women with cyst…

This study looks at how well a daily pill called relugolix combination therapy works for easing endometriosis pain over 24 weeks in everyday medical practice. About 33 women aged 18 to 50 with confirmed endometriosis and moderate to severe pain will take part. The goal is to see …

This study tests a portable device called ActiTENS mini that uses mild electrical pulses to relieve chronic pelvic pain in women with endometriosis. About 208 women will use the device daily for 30 minutes over three 3-month periods, comparing different stimulation strengths. The…

This study tests an experimental drug called HMI-115 in 540 women with moderate to severe endometriosis pain. Participants will receive either the drug or a placebo for 24 weeks, with a follow-up extension. The goal is to see if the drug reduces pain during periods and pelvic pai…

This study tests a new device called Hyivy that people with endometriosis can use at home to manage chronic pelvic pain. The goal is to see if it reduces pain without using hormones. Twenty adults with endometriosis and ongoing pelvic pain will use the device and report their pai…

This study tests whether magnetic stimulation using a 'Tesla chair' can reduce pelvic pain in women with endometriosis whose pain persists despite surgery, hormones, or painkillers. About 30 premenopausal women with confirmed endometriosis and significant pelvic pain will receive…

This study tests whether a 10-week virtual mindfulness program can improve quality of life for people with endometriosis-related chronic pelvic pain. Researchers will enroll 124 adults aged 18-50 with a diagnosis of endometriosis. Participants will attend online mindfulness sessi…

This study tests whether psychological support—individual therapy, group sessions, or a mix—can improve quality of life and mental health in women with endometriosis. Forty participants will be randomly assigned to one of four groups, including a no-intervention control. The goal…

This study compares two laparoscopic hysterectomy methods (total vs supracervical) for benign conditions like fibroids and endometriosis. About 500 women will be followed for 3 years to see which surgery leads to better quality of life and fewer complications. The goal is to help…

This study tests whether up to 9 sessions of electroacupuncture can reduce pelvic pain in women with suspected endometriosis who are scheduled for diagnostic surgery. Researchers will measure pain levels, quality of life, and pain medication use. The goal is to find a non-drug wa…

This study will test whether following a Mediterranean diet can improve quality of life and reduce pain in women with endometriosis, a chronic inflammatory condition. Researchers will enroll 104 women aged 18-45 who have been diagnosed with endometriosis. Participants will follow…

This study compares a new surgical technique (IDLnR) with standard laparoscopic surgery for bowel endometriosis. About 192 women aged 18-55 with confirmed bowel endometriosis will be randomly assigned to one of the two surgeries. The goal is to see if the new method improves bowe…

This study follows 100 women with deep endometriosis for two years to see if their lesions grow, shrink, or stay the same on ultrasound. Researchers will also track symptoms and quality of life to understand how the disease progresses and whether ultrasound checkups are always ne…

This study aims to understand why endometriosis develops and worsens by looking at immune cells and gut bacteria. Researchers will compare 40 women with and without endometriosis, collecting tissue, blood, and stool samples. The goal is to find new ways to treat this painful cond…

This study explores whether women with endometriosis who use AI tools like ChatGPT to prepare for their doctor visit have better or worse experiences. Researchers will compare satisfaction, trust, and treatment plan follow-through between AI users and non-users. The goal is to un…

This study compares two types of ultrasound to see which better measures severe bowel endometriosis before surgery. About 98 women will get both a standard vaginal ultrasound and a special ultrasound during their operation. The goal is to help surgeons plan more precisely and pos…

This study tests whether using ultrasound during surgery helps doctors better remove deep endometriosis from the bowel while keeping the bowel wall safe. About 57 women aged 20-60 with bowel endometriosis will take part. The goal is to see if ultrasound measurements during surger…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples to measure a molecule called CGRP and hormone levels. The goal is to better understand th…

This study looks at why some women have repeated failed embryo implants or miscarriages during fertility treatments. Researchers will compare uterine tissue and blood samples from 100 women—half with a history of these problems, half without—to see if differences in immune cells …

This study looks at the immune system of women aged 18-40 with chronic pelvic pain that hasn't improved with hormone treatment. Researchers will measure specific immune markers in the blood to see if there is a unique pattern linked to the pain. The goal is to better understand t…

This study looks at fluid and tissue from the womb and eggs of women with moderate to severe endometriosis. Researchers want to find biological markers that might explain why some women have trouble getting pregnant. The goal is to use this information to create more personalized…

This study aims to grow human diaphragm muscle cells in the lab for the first time, using tissue from women having surgery for endometriosis. Researchers will compare these cells to arm muscle cells to find unique features of the diaphragm. This tool could help develop new therap…

This study looks at whether women with deep endometriosis affecting the bowel have a higher chance of developing colorectal cancer. Researchers will compare gene activity in healthy and endometriosis-affected bowel tissue from 30 women having surgery. The goal is to improve risk …

This study tests whether a special full-body PET/CT scan can spot endometriosis without needing surgery. About 30 women with suspected endometriosis will get two scans using different tracers to highlight bleeding and scarring. The scan results will be compared to findings from t…

This study aims to find out if certain environmental chemicals, called persistent organic pollutants (POPs), are linked to more severe endometriosis. Researchers will measure levels of these pollutants in blood samples from 650 women with endometriosis living in the Paris region.…