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Endometriosis diagnosis without surgery? new study tests protein biomarkers

NCT ID NCT07713797

Diagnosis Sponsor: Trio Fertility Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

Endometriosis is a painful condition where tissue similar to the uterine lining grows outside the uterus, often causing pain and infertility. Currently, diagnosis requires invasive surgery. This study investigates whether measuring two proteins, SNCG and BCL6, in blood or menstrual fluid can accurately detect endometriosis. Researchers will compare levels of these proteins in women with and without the condition to see if they can serve as a non-invasive diagnostic tool.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
SNCG and BCL6 protein levels measured via EndoID ELISA kit
What this could lead to
If successful, this could lead to a simple blood or menstrual fluid test for endometriosis, replacing the need for invasive surgery to diagnose the condition.
What could go wrong
This is an early observational study with only 100 participants. The proteins may not reliably distinguish endometriosis from other conditions, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will focus on measuring circulatory SNCG and BCL6 concentrations in patients with endometriosis compared to age-matched healthy subjects without endometriosis. Patients with confirmed endometriosis, and the healthy control group will be recruited at TRIO Fertility following informed consent.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Endometriosis Group: * Women of reproductive age group (18Y-45Y). * Women with active endometriosis diagnosed by ultrasound/MRI/laparoscopy. Exclusion Criteria for Endometriosis Group: * Women \<18Y and \>45Y. * Women with endometriosis during stimulation with gonadotropins. * Current or prior history of uterine, ovarian, colon, pancreatic, breast or any other type of cancer. * Any prior history of chronic illness. * Pregnant women. Inclusion Criteria for Control Group: * Women of reproductive age group (18Y-45Y). * Women without endometriosis and any other gynaecological problem. Exclusion Criteria for Endometriosis Group: * Women \<18Y and \>45Y * Prior history of any disease including cancer or chronic illness. * Pregnant women.

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Conditions

The condition(s) this trial relates to.

endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Trio Fertility

    RECRUITING

    Toronto, Ontario, M5G 2K4, Canada

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