Psilocybin's brain effects in migraine under the microscope

NCT ID NCT06464367

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates why psilocybin may reduce headache burden after just a few doses. Researchers will measure brain connectivity, synaptic density, inflammation markers, and sleep patterns in migraine patients and healthy volunteers before and after a single dose of psilocybin or an active placebo. The goal is to uncover the biological mechanisms behind psilocybin's potential long-lasting effects on migraine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin
What this could lead to: If the brain changes observed after psilocybin are linked to lasting headache relief, this could point toward new treatments for migraine.
What could go wrong: This is a very early, small study focused on understanding mechanisms, not proving effectiveness. The results may not lead to a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

VA Connecticut Healthcare System
RECRUITING

West Haven, Connecticut, 06516, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

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