Head-to-Head: which migraine pill works best?

NCT ID NCT06972056

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This study compares three oral medications used to prevent migraines: atogepant (a newer drug), topiramate, and propranolol (both older). About 1,335 adults with migraine will be randomly assigned to one of the three drugs for 12 weeks. Researchers will track headache frequency and how long people stay on their assigned medication to see which option works best and is most tolerable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atogepant, propranolol, topiramate
What this could lead to: If successful, this could help doctors choose the most effective and tolerable migraine prevention medication for patients.
What could go wrong: This is a comparative effectiveness study, not a test for a new cure. Results may show no clear winner, and individual responses vary. Side effects are possible with each drug.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder migraine with aura

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Advanced Research Institute
RECRUITING

Portland, Oregon, 97223, United States
Advanced Research Institute Ogden
RECRUITING

Ogden, Utah, 84405, United States
Advanced Research Institute Reno
RECRUITING

Reno, Nevada, 89511, United States
Apple Med Research
RECRUITING

Miami, Florida, 33126, United States
Brown University Health
RECRUITING

Providence, Rhode Island, 02903, United States
Clinical Research Institute
RECRUITING

Los Angeles, California, 90048, United States
Clinical Trials of New England
RECRUITING

Hyde Park, Massachusetts, 02136, United States
DHR Health Headache Center
RECRUITING

McAllen, Texas, 78504, United States
Desert Physicians Medical Group
RECRUITING

Palm Springs, California, 92262, United States
JFK Neuroscience Institute
RECRUITING

Edison, New Jersey, 08820, United States
Keck School of Medicine of USC
RECRUITING

Los Angeles, California, 90033, United States
Marshfield Clinic Research Institute
RECRUITING

Marshfield, Wisconsin, 54449, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32066, United States
Memorial Healthcare
RECRUITING

Hollywood, Florida, 33021, United States
Mt Sinai Icahn School of Medicine
RECRUITING

New York, New York, 10029, United States
Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
Neuroscience Research Center
RECRUITING

Overland Park, Kansas, 66210, United States
Northern Arizona Healthcare
RECRUITING

Flagstaff, Arizona, 86001, United States
Northwell Health
RECRUITING

Manhasset, New York, 11030, United States
Nuvance Health Institute
RECRUITING

Kingston, New York, 12401, United States
Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
Onsite Clinical Solutions Ballantyne
RECRUITING

Charlotte, North Carolina, 28277, United States
Onsite Clinical Solutions Mecklenburg
RECRUITING

Charlotte, North Carolina, 28211, United States
Onsite Clinical Solutions Park Cedar Dr.
RECRUITING

Charlotte, North Carolina, 28210, United States
Onsite Clinical Solutions Salisbury
RECRUITING

Salisbury, North Carolina, 28144, United States
The Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
The Neurology Group
RECRUITING

Pomona, California, 91767, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Vanderbilt Medical Center
RECRUITING

Nashville, Tennessee, 37215, United States
Wake Forest University Health
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Washington University St Louis
RECRUITING

St Louis, Missouri, 63110, United States
West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States

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