Could a single ketamine infusion ease daily headaches for months?

NCT ID NCT05306899

Recruiting now Symptom relief Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a one-time high-dose intravenous ketamine infusion can reduce the number and intensity of headaches in people with chronic daily headaches. About 56 adults will receive either ketamine or a placebo (saline) and be followed for three months. The goal is to see if ketamine can safely provide lasting relief from this debilitating condition.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Chronic Pain headache disorder migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC DAILY HEADACHE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Toronto Western Hospital
RECRUITING

Toronto, Ontario, M5T 2S8, Canada

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Women's College Hospital
RECRUITING

Toronto, Ontario, M5S 1B2, Canada

Contact Email: •••••@•••••