Scientists track the earliest clues of a migraine before pain begins

NCT ID NCT07681466

Recruiting now Knowledge-focused Sponsor: University of Roma La Sapienza Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study investigates the sequence of early warning signs, called premonitory symptoms, that occur before a migraine headache starts. Researchers will follow 500 adults with migraine who will record their symptoms using an electronic diary for up to five attacks. The goal is to identify which symptoms appear first and how long before the headache they occur, which could help people better predict and manage their migraines.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help people with migraine recognize early signs and take preventive action sooner.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to immediate clinical changes, and results depend on accurate self-reporting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

Locations

Sapienza University of Rome, Polo Pontino, centro cefalee, ICOT
RECRUITING

Latina, Italy, 04100, Italy

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