Can CBD oil stop migraines before they start? new trial aims to find out

NCT ID NCT03972124

Recruiting now Disease control Sponsor: University of Calgary Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether CBD oil (a non-psychoactive cannabis compound) can prevent chronic migraines. About 72 adults with frequent migraines will receive either a low dose of CBD, a higher dose, or a placebo for several months. Researchers will track changes in headache days to see if CBD works better than a dummy pill.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CBD oil (cannabidiol, purified to less than 1% THC)
What this could lead to: If it works, this could provide a new, non-psychoactive option for preventing chronic migraines with fewer side effects than current medications.
What could go wrong: This is a small, early-phase trial (72 people), so results may not apply to everyone. CBD may not reduce headache days more than placebo, and long-term safety is not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MIGRAINE

Contacts and locations

Locations

CHAMP Research (Calgary Headache Assessment & Management Program)
RECRUITING

Calgary, Alberta, T3M 1M4, Canada

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