Steroid shots may tame cluster headaches for months

NCT ID NCT05324748

Recruiting now Disease control Sponsor: Leiden University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether repeated injections of a steroid around a nerve in the back of the head can prevent cluster headache attacks in people with chronic cluster headache. Fifty adults with at least four attacks per week will receive either the steroid or a placebo injection every few weeks. The goal is to see if the steroid keeps attacks under control longer than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Methylprednisolone (steroid injection)
What this could lead to: If successful, this could offer a new, non-daily treatment option to reduce cluster headache attacks for weeks or months at a time.
What could go wrong: This is a small Phase 3 trial with only 50 participants. The benefit may be modest, and steroid injections carry risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cluster headache syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLUSTER HEADACHE

Contacts and locations

Locations

Canisius Wilhelmina Ziekenhuis
RECRUITING

Nijmegen, Netherlands
Leiden University Medical Center
RECRUITING

Leiden, Netherlands

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