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Migraine crystal ball: study aims to predict treatment success

NCT ID NCT06459648

Recruiting now Knowledge-focused Sponsor: Fundación de Investigación Biomédica - Hospital Universitario de La Princesa Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study is looking for ways to predict which migraine patients will respond well to a class of drugs called anti-CGRP monoclonal antibodies. Researchers will analyze clinical, biological, and brain imaging data from 350 adults with frequent migraines. The goal is to find biomarkers that help doctors choose the right treatment from the start, reducing trial-and-error and improving patients' quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Anti-CGRP monoclonal antibodies (Erenumab, Galcanezumab, Fremanezumab, Eptinezumab)
What this could lead to
If successful, this could help doctors predict which migraine treatment will work best for each patient, saving time and improving quality of life.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear predictors, and results may not apply to all migraine patients.

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Conditions

The condition(s) this trial relates to.

Headache migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Hospital Clínico Universitario Lozano Blesa

    RECRUITING

    Zaragoza, Aragon, 50009, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital Clínico Universitario de Valladolid

    RECRUITING

    Valladolid, Castille and León, 47010, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

  • Hospital Universitari Vall d'Hebron Research Institute

    RECRUITING

    Barcelona, Catalonia, 08035, Spain

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital Universitario Donostia

    RECRUITING

    Donostia / San Sebastian, Basque Country, 20014, Spain

    Contact Email: •••••@•••••

    Contact

  • Hospital Universitario Marqués de Valdecilla

    RECRUITING

    Santander, Cantabria, 39008, Spain

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital Universitario Politécnico La Fe

    RECRUITING

    Valencia, Valencia, 46026, Spain

    Contact Email: •••••@•••••

    Contact

  • Hospital Universitario de La Princesa

    RECRUITING

    Madrid, Madrid, 28006, Spain

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

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