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Heart hole and migraine mystery: new study digs into genetic clues

NCT ID NCT07349004

Recruiting now Knowledge-focused Sponsor: Azienda Usl di Bologna Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is investigating why some people with migraine with aura also have a small hole in the heart called a PFO. Researchers will compare genetic differences and blood flow patterns between 240 adults who have migraine with aura, some with a PFO and some without. No new treatments are being tested; the goal is to better understand the connection and guide future research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could reveal why some people with migraine with aura also have a small hole in the heart, pointing toward better prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It will not directly test any therapy, and results may not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 migraine with aura patent foramen ovale

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE WITH AURA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • IRCCS Istituto delle Scienze Neurologiche di Bologna - AUSL of Bologna

    RECRUITING

    Bologna, BO, 40139, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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