Could a daily pill stop chronic migraines in teens?

NCT ID NCT06810505

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study tests whether the drug atogepant (Qulipta) can safely prevent chronic migraines in teenagers aged 12 to 17. About 420 teens with chronic migraine will take either atogepant or a placebo pill daily for 12 weeks. Researchers will track side effects and changes in monthly migraine days to see if the drug works better than a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atogepant (oral tablet, also known as Qulipta or Aquipta)
What this could lead to: If it works, this could provide a new preventive treatment option for chronic migraine in teenagers, reducing the number of migraine days per month.
What could go wrong: This is an early-phase study in teens, and atogepant is already approved for adults. However, results may differ in adolescents, and side effects or lack of effectiveness compared to placebo are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MIGRAINE

Contacts and locations

Locations

Accellacare - Long Beach /ID# 270398
RECRUITING

Long Beach, California, 90807, United States
Access Clinical Trials Inc /ID# 270280
RECRUITING

Nashville, Tennessee, 37203, United States
Advanced Research Center /ID# 270257
RECRUITING

Anaheim, California, 92805, United States
Alpine Research Organization - Clinton /ID# 276527
RECRUITING

Clinton, Utah, 84015, United States
Athleticomed Sp. z o.o /ID# 270243
RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-752, Poland
Auzmer Research /ID# 271158
COMPLETED

Lakeland, Florida, 33813, United States
Canisius-Wilhelmina Ziekenhuis /ID# 270374
RECRUITING

Nijmegen, Gelderland, 6532 SZ, Netherlands
Caribbean Medical Research Center Headlands /ID# 271300
RECRUITING

San Juan, 00918-3501, Puerto Rico
Cct Research - Papillion Research Center /ID# 270393
RECRUITING

Papillion, Nebraska, 68046, United States
Clinical Research Center Medic-R /ID# 270235
RECRUITING

Poznan, Greater Poland Voivodeship, 60-848, Poland
Clinpoint Trials /ID# 270261
RECRUITING

Waxahachie, Texas, 75165, United States
Deaconess Midtown Hospital /ID# 270572
RECRUITING

Evansville, Indiana, 47710, United States
Dent Neurologic Institute - Amherst /ID# 270260
RECRUITING

Amherst, New York, 14226, United States
Earle Research /ID# 270424
RECRUITING

Houston, Texas, 77058, United States
Encore Medical Research - Weston /ID# 271139
RECRUITING

Weston, Florida, 33331, United States
Excell Research /ID# 270258
RECRUITING

Oceanside, California, 92056, United States
Fondazione IRCCS Istituto Neurologico Carlo Besta /ID# 270756
RECRUITING

Milan, Milano, 20133, Italy
Frontier Clinical Research - Kingwood /ID# 271053
RECRUITING

Kingwood, West Virginia, 26537, United States
Frontier Clinical Research - Scottdale /ID# 270854
RECRUITING

Scottdale, Pennsylvania, 15683, United States
Frontier Clinical Research - Smithfield /ID# 270849
RECRUITING

Smithfield, Pennsylvania, 15478, United States
Great Ormond Street Children's Hospital /ID# 271550
RECRUITING

London, Greater London, WC1N 3HZ, United Kingdom
HagaZiekenhuis /ID# 270379
RECRUITING

The Hague, South Holland, 2545 AA, Netherlands
Headache Wellness Center /ID# 270568
RECRUITING

Greensboro, North Carolina, 27405, United States
Healthy Perspectives - Innovate Mental Health Services /ID# 270847
RECRUITING

Nashua, New Hampshire, 03060, United States
Herlev Hospital /ID# 270482
RECRUITING

Herlev, Capital Region, 2730, Denmark
Highland Clinical Research /ID# 270281
RECRUITING

Salt Lake City, Utah, 84124, United States
Hospital da Luz /ID# 277991
RECRUITING

Lisbon, Lisbon District, 1500-650, Portugal
Konan Medical Center /ID# 270486
RECRUITING

Kobe, Hyōgo, 658-0064, Japan
London Health Sciences Centre - Victoria Hospital & Children's Hospital /ID# 270659
RECRUITING

London, Ontario, N6A 5W9, Canada
Lumos Clinical Research Center /ID# 270582
RECRUITING

San Jose, California, 95124, United States
MIGRE Polskie Centrum Leczenia Migreny /ID# 270239
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
McGill University Health Centre - Glen Site /ID# 270662
COMPLETED

Montreal, Quebec, H4A 3J1, Canada
Medway Maritime Hospital /ID# 271885
RECRUITING

Gillingham, Kent, ME7 5NY, United Kingdom
Michigan Headache & Neurological Institute /ID# 270942
RECRUITING

Ann Arbor, Michigan, 48104, United States
My Preferred Research /ID# 270312
RECRUITING

Miami, Florida, 33155, United States
Nagaseki Headache Clinic /ID# 271699
RECRUITING

Kai, Yamanashi, 400-0124, Japan
Neuro Pain Research Center /ID# 271048
RECRUITING

Fresno, California, 93710, United States
Northwest Florida Clinical Research Group, LLC /ID# 270833
RECRUITING

Gulf Breeze, Florida, 32561, United States
Oha-Med Sp. Z O.O /ID# 270242
RECRUITING

Warsaw, Masovian Voivodeship, 01-018, Poland
Ospedale Pediatrico Bambino Gesù /ID# 270759
RECRUITING

Rome, Roma, 00165, Italy
Pantheon Clinical Research /ID# 270259
RECRUITING

Bountiful, Utah, 84010, United States
Pediatric Neurology & Epilepsy Center Of Central Florida - Winter Park /ID# 275263
RECRUITING

Winter Park, Florida, 32789, United States
Preferred Research Partners - Fayetteville /ID# 270419
COMPLETED

Fayetteville, Arkansas, 72703, United States
Preferred Research Partners /ID# 270389
RECRUITING

Little Rock, Arkansas, 72211, United States
Proven Endpoints LLC /ID# 270269
RECRUITING

Ridgeland, Mississippi, 39157, United States
Regionshospitalet Godstrup /ID# 270481
RECRUITING

Herning, Central Jutland, 7400, Denmark
Rehabilitation and Neurological Services /ID# 270782
RECRUITING

Huntsville, Alabama, 35805, United States
Royal Aberdeen Children's Hospital /ID# 271664
RECRUITING

Aberdeen, Scotland, AB25 2ZG, United Kingdom
Rozsavolgyi Rendelo-Ceba Bt. /ID# 271500
RECRUITING

Budapest, 1141, Hungary
Semmelweis Egyetem /ID# 271219
RECRUITING

Budapest, 1085, Hungary
Specjalistyczne Gabinety Sp. z o.o /ID# 270238
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-539, Poland
Stepping Hill Hospital-Stockport NHS foundation trust /ID# 271883
RECRUITING

Stockport, SK2 7JE, United Kingdom
Sunwise Clinical Research /ID# 270431
RECRUITING

Walnut Creek, California, 94596, United States
Tanaka Neurosurgery & Headache Clinic /ID# 271346
RECRUITING

Kagoshima, 890-0052, Japan
Tendo Brain Clinic /ID# 271410
RECRUITING

Tendo-shi, Yamagata, 994-0083, Japan
Tokyo Headache Clinic /ID# 271610
RECRUITING

Shibuya-ku, Tokyo, 151-0051, Japan
Tokyo Medical University Hospital /ID# 270487
RECRUITING

Shinjuku-ku, Tokyo, 160-0023, Japan
Tominaga Clinic - Osaka /ID# 270483
RECRUITING

Osaka, Osaka, 556-0015, Japan
UT Health Austin at Dell Childrens Neurology Clinic /ID# 270577
RECRUITING

Austin, Texas, 78723-3079, United States
Umenotsuji Clinic /ID# 270484
RECRUITING

Kochi, Kochi, 780-8011, Japan
Unidade Local de Saude de Almada-Seixal, EPE /ID# 278092
RECRUITING

Almada, Setúbal District, 2805-267, Portugal
Unidade Local de Saude de Coimbra /ID# 277993
RECRUITING

Coimbra, 3000-075, Portugal
Unidade Local de Saude de Santa Maria /ID# 277997
RECRUITING

Lisbon, 1649-035, Portugal
Unidade Local de Saude de Santo Antonio /ID# 278090
RECRUITING

Porto, 4099-003, Portugal

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