Could a common antidepressant and seizure drug tame Meniere's vertigo?
NCT ID NCT05582837
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a combination of two existing drugs, nortriptyline and topiramate, can reduce vertigo and other symptoms in people with Meniere's disease. Forty adults with active Meniere's will take the drugs or a placebo for 8 weeks. The goal is to see if this approach improves quality of life and reduces tinnitus and stress.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nortriptyline and topiramate (drug combination)
- What this could lead to
- If it works, this could offer a new, non-surgical option to ease vertigo and other symptoms of Meniere's disease, improving quality of life.
- What could go wrong
- This is a small, early-phase trial with only 40 people. The drugs may not work better than a placebo, and side effects like drowsiness or dizziness are possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of California, Irvine Medical Center ENT Clinic (Pavilion 2)
RECRUITINGOrange, California, 92868, United States
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