Could this pill ease Meniere's hearing loss and dizziness?

NCT ID NCT04677972

Completed Disease control Sponsor: Sound Pharmaceuticals, Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tested an experimental drug called SPI-1005 (ebselen) in 254 adults with Meniere's disease, a condition causing hearing loss, ringing in the ears, and dizziness. Participants received either the drug or a placebo for a set period, followed by an open-label phase where everyone could get the drug. The goal was to see if SPI-1005 safely improves hearing and reduces symptoms like tinnitus and vertigo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ebselen (SPI-1005)
What this could lead to: If successful, this could lead to a new treatment option for Meniere's disease that helps protect hearing and reduce tinnitus and vertigo symptoms.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The drug may not prove better than placebo, and side effects are possible. It is not a cure, and patients may still need ongoing management.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Dizziness hearing loss disorder Meniere disease Tinnitus Vertigo

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENIERE DISEASE MÉNIÈRE

Contacts and locations

Locations

Advanced ENT & Allergy

Louisville, Kentucky, 40207, United States
ENT and Allergy Associates of Florida

Boca Raton, Florida, 33487, United States
George Washington University

Washington D.C., District of Columbia, 20037, United States
House Clinic

Los Angeles, California, 90057, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Kansas University Medical Center

Kansas City, Kansas, 66160, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Piedmont Ear, Nose & Throat Associates

Winston-Salem, North Carolina, 27103, United States
Sacramento Ear, Nose, & Throat

Roseville, California, 95661, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19144, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of Southern California

Los Angeles, California, 90033, United States

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