Can a Triple-Dose of ICU tweaks save more brains after cardiac arrest?

NCT ID NCT05564754

Ongoing Disease control Sponsor: Region Skane Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose fever control, high vs. standard blood pressure target). The goal is to see which approach leads to more people alive and with good brain function at 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Feedback-controlled temperature device; vasopressors; sedation drugs
What this could lead to: If it works, this could establish a standard ICU protocol to improve survival and brain function after cardiac arrest.
What could go wrong: This is a large trial but still testing combinations of existing treatments; results may not show a clear winner or may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CARDIAC ARREST WITH SUCCESSFUL RESUSCITATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest Hypoxia, Brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST WITH SUCCESSFUL RESUSCITATION HYPOXIA, BRAIN

Contacts and locations

Locations

Austin Hospital

Melbourne, Victoria, Australia
Bern University Hospital

Bern, Switzerland
Bristol Royal Infirmary

Bristol, United Kingdom
Cardiff University Hospital

Cardiff, United Kingdom
Centre Hospitalier de Luxembourg

Luxembourg, Luxembourg
Charite University Hospital

Berlin, Germany
Christchurch Hospital

Christchurch, New Zealand
DCCM ICU

Auckland, New Zealand
Essex Cardiothoracic Centre

Basildon, United Kingdom
Ghent University Hospital

Ghent, 9000, Belgium
HUB Hôpital Erasme

Brussels, 1077, Belgium
Hallands hospital

Halmstad, Halland County, Sweden
Helsingborg Hospital

Helsingborg, Skåne County, Sweden
Helsinki Helsingforgs University Central Hospital

Helsinki, Finland
Jorvi Hospital

Espoo, Finland
Jyväskylä Hospital

Jyväskylä, Finland
Kalnes Hospital

Kalnes, Norway
Karlstad hospital

Karlstad, Sweden
Karolinska University Hospital

Stockholm, Sweden
King Abdulaziz Medical City

Riyadh, Saudi Arabia
Kings College Hospital

London, United Kingdom
Kuopio University Hospital

Kuopio, Finland
Leeds General Infirmary

Leeds, United Kingdom
Liverpool Hospital

Liverpool, New South Wales, Australia
Lübeck University Hospital

Lübeck, Germany
Meilahti Hospital

Helsinki, 00290, Finland
Middlemore ICU

Auckland, New Zealand
Nepean Hospital

Kingswood, New South Wales, Australia
North Estonia Medical Centre, Tallinn

Tallinn, 13409, Estonia
North Shore ICU NZ

Auckland, New Zealand
Oslo University Hospital

Oslo, Norway
Oulu University Hospital

Oulu, Finland
Princess Alexandra Hospital

Brisbane, Queensland, Australia
Royal North Shore Hospital

Sydney, New South Wales, Australia
Sahlgrenska University Hospital

Gothenburg, Sweden
San Martino Hospital Genova

Genova, Italy
Skaraborg Hospital Skovde

Skövde, Sweden
Skåne University Hospital

Lund, Skåne County, Sweden
Skåne University Hospital Malmö

Malmö, Skåne County, Sweden
Soerlandet Hospital Arendal

Arendal, Norway
St Bartholomew's Hospital

London, United Kingdom
St Gallen Hospital

Sankt Gallen, Switzerland
St George Hospital

Sydney, New South Wales, Australia
St Georges University Hospital

London, United Kingdom
St Vincents University Hospital

Dublin, Ireland
Stavanger University Hospital

Stavanger, Norway
Tampere University Hospital

Tampere, Finland
Tan Tock Seng Hospital

Singapore, Singapore
The Prince Charles Hospital

Brisbane, Queensland, Australia
The Sutherland Hospital

Sydney, New South Wales, Australia
Tubingen University Hospital

Tübingen, Germany
University Hospital Zürich

Zurich, Switzerland
University Hospital of Umeå

Umeå, Sweden
Wellington Hospital

Wellington, New Zealand
Whangarei ICU

Northland, New Zealand
Ziekenhuis Oost-Limburg Hospital

Lanaken, 3620, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.