Neurovascular disorder

This trial investigates whether a procedure to remove a blood clot from the basilar artery—a major vessel at the back of the brain—can improve recovery in people with severe stroke. Participants are adults aged 18 to 80 who have a large area of brain damage and can be treated wit…

This study tests whether combining a gentle electrical brain stimulation (called FNS) with sling-based exercises can help people who have paralysis on one side after a stroke. The trial will enroll 54 adults aged 18-70 who had a stroke within the last 6 months. Participants will …

This trial tests whether using a balloon guide catheter along with a filter can better protect the brain during carotid artery stenting. People with narrowed neck arteries (carotid stenosis) who need stenting are randomly assigned to get either the balloon-plus-filter combo or a …

This study tests a stent (Carotid WALLSTENT) used with a special brain protection system (ENROUTE NPS) in 60 Chinese patients with narrowed carotid arteries. The goal is to see if the combination can be safely delivered to prevent strokes. Patients must have significant artery na…

This study compares two methods to remove large blood clots from the brain during a stroke: using a super large suction catheter versus a stent retriever. About 708 adults with acute ischemic stroke will be randomly assigned to one of the two techniques. The goal is to see which …

This study tests whether stroke survivors can safely use a robot called ReHandyBot to exercise their hand at home without a therapist present. Participants first learn how to use the device at a clinic, then take it home to train on their own. The goal is to see if unsupervised h…

This phase 3 trial tests whether a new emergency stroke unit, equipped with a hybrid CT and X-ray machine (NeuAngio-CT), can speed up clot removal in people having a severe stroke. About 232 adults aged 18-60 with acute ischemic stroke will be randomly assigned to either the new …

This phase 3 trial tests whether giving clot-busting drugs directly into the blocked brain artery (intra-arterial thrombolysis) helps people recover better from a medium-vessel stroke. About 306 adults aged 18-80 with acute stroke will be randomly assigned to receive either the d…

This early study tests whether a drug called sirolimus (rapamycin), given directly into the brain's fluid spaces, can prevent hydrocephalus after a severe brain hemorrhage. Hydrocephalus is a dangerous buildup of fluid that often requires a permanent surgical shunt. The trial wil…

This trial tests whether giving blood pressure medication inside a mobile stroke unit—a special ambulance with a CT scanner—can improve outcomes for people having a brain bleed. About 706 adults with high blood pressure and a recent stroke will be randomly assigned to either the …

This study tests whether a single daily polypill (combining blood pressure, cholesterol, and anti-clotting drugs) can help recent stroke survivors in Ghana avoid future strokes or heart attacks. About 500 participants will take the polypill or receive usual care for 24 months. Th…

This trial tests whether taking two inexpensive migraine prevention drugs together works better than taking either one alone. Adults aged 18 to 55 who have at least four migraines per month will receive propranolol, flunarizine, or both for 12 weeks. The goal is to see which appr…

This phase 2 trial tests whether taking a probiotic supplement (OMNi-BiOTiC® SR-9) twice daily for 90 days can improve gut health and recovery in people aged 60 and older who have had an acute ischemic stroke. The study will compare the probiotic to a placebo in 220 participants,…

This study will follow 5,000 adults with carotid artery disease who receive a treatment called TCAR using the ENROUTE system. The goal is to see how safe and effective the device is in real-world settings, especially for groups not well-studied before. Researchers will track majo…

This study tests whether a stellate ganglion block (a nerve block injection) can improve neurological outcomes in people who have had a bleeding stroke from a ruptured aneurysm. The procedure is done before surgery to reduce brain artery spasms and improve blood flow. Researchers…

This study tests a specially designed suction tube that cleans deep throat secretions under direct laryngoscope guidance. The goal is to see if it reduces pneumonia within 28 days in stroke patients who have trouble swallowing or coughing. Participants are adults with acute ische…

This study tests whether a non-invasive brain stimulation technique called cTBS, guided by each patient's brain scan, can improve arm and leg movement after a stroke. About 584 adults who had a stroke within the past two weeks will receive either real or sham stimulation alongsid…

This study tests whether adding 20 minutes of moderate-to-high intensity aerobic exercise before constraint-induced movement therapy helps stroke survivors walk better. Fifty adults who had a stroke at least 6 months ago will take part in a 4-week intensive program, followed by a…

This study tests a personalized brain stimulation technique called cTBS to help people recover movement after a stroke. Researchers use each patient's brain scan to target the stimulation precisely. Sixty participants will receive either real or sham stimulation alongside standar…

This study tests whether people who have had a minor stroke or a high-risk mini-stroke can safely stop one of their two blood thinners earlier than usual. About 3,800 participants will have their blood tested to see how they respond to the drug clopidogrel. Those who are sensitiv…

This study tests whether patients with a heart pump (LVAD) can safely stop taking aspirin while continuing warfarin. The goal is to reduce bleeding problems without increasing dangerous clots. About 370 participants will be randomly assigned to receive either aspirin or a placebo…

This study tests whether giving aspirin early after repairing a ruptured brain aneurysm helps patients recover better. About 388 adults who had a bleeding aneurysm will receive either aspirin or a placebo for 10–14 days. The goal is to see if aspirin reduces brain complications a…

This study tests whether using cord blood, rich in fetal hemoglobin, for transfusions in preterm infants can reduce serious complications like blindness, lung disease, and gut problems. Researchers will compare outcomes in 200 very low birth weight babies who receive either cord …

This pilot study tests whether an active smartwatch that gives real-time feedback, combined with regular nurse coaching, can help people who had a minor stroke or TIA walk more each day. Fifty participants will be randomly assigned to either an active smartwatch or a passive one …

This study tests whether a set of dietary supplements taken at different phases of a migraine cycle can improve quality of life and reduce headache days in adults with migraine. Participants take a daily foundational supplement, with additional supplements during the luteal phase…

This study tests whether a care model led by rural doctors and supported by telemedicine can reduce strokes, heart failure, and heart-related deaths in adults aged 65 and older who are at high risk of stroke in rural China. About 2,500 participants from 39 village clinics will be…

This trial investigates whether adding early lumbar drainage to standard care (a drain in the head plus clot-dissolving medication) improves long-term outcomes for people with bleeding into the brain's fluid-filled spaces. The study includes adults aged 18 to 85 who have had a fi…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve balance and body control in people who have had a stroke. Twenty-two participants will receive either the stimulation plus balance training or balance training alone. The goal is …

This study tests a new, simple procedure done right after doctors remove a blood clot from the brain in severe stroke patients. The procedure involves briefly inflating and deflating a tiny balloon to gently restore blood flow, which may prevent extra brain damage. About 288 to 4…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This early-stage trial tests whether stem cells from human umbilical cords are safe and might help people recover from a severe stroke. About 35 adults who had a stroke within the last 48 hours will receive either the stem cells or a placebo. The study will check for side effects…

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

This study tests a drug called pro-urokinase in people who have had a stroke in the back part of the brain (posterior circulation) and can be treated within 4.5 to 24 hours after symptoms start. About 586 participants will receive either the drug or a placebo, along with standard…

This study tests whether the clot-busting drug tenecteplase is safe and effective for people having a stroke who took a blood thinner (DOAC) within the last 48 hours. About 660 adults will receive either tenecteplase or a placebo within 4.5 hours of stroke symptoms. The goal is t…

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This study looks at whether doing a balloon angioplasty or placing a stent right after removing a blood clot from the brain can help people who have a stroke caused by a hardened artery. About 420 adults will be in the study. The goal is to see if this extra step improves recover…

This study tests whether a GLP-1 receptor agonist (a type of diabetes medicine) can reduce brain swelling and improve recovery in people who have had a bleeding stroke. About 200 adults with a specific type of brain bleed will receive either standard care or the drug plus standar…

This study tests whether a treat-and-extend schedule for aflibercept eye injections works better than the standard as-needed approach for people with diabetic macular edema who have not had prior treatment. About 186 participants will receive three monthly injections, then either…

This study tests a new device, the SOFIA Flow 88 Aspiration Catheter, to treat acute ischemic stroke caused by a large blocked artery. About 200 adults with moderate to severe stroke will be enrolled. The goal is to safely restore blood flow to the brain using only this catheter,…

This study tests whether a set of simple treatments—daily blood pressure checks, dietitian visits, hearing and vision tests, and mood screening—can help preserve thinking and memory after a stroke. About 50 adults who recently had a mild stroke will either receive this care bundl…

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study looks at 2,000 people who had a stroke to see which blood-thinning medicine works best to stop another stroke. The drugs being compared are indobufen, aspirin, cilostazol, and clopidogrel, used alone or in pairs. Researchers will track strokes and bleeding problems for…

This study tests whether giving a clot-busting drug called tenecteplase before a mechanical clot removal procedure helps people with large ischemic strokes recover better than the procedure alone. About 486 adults with large-vessel occlusion strokes will be randomly assigned to o…

This pilot study tests whether a daily probiotic supplement (Lactobacillus plantarum 299v) can reduce retinal swelling and improve vision in people with diabetic macular edema. Thirty-six participants will take the probiotic twice daily for four months. Researchers will measure c…

This study compares two ways to remove blood clots from the brain during a stroke. About 500 adults who have a stroke from a large blocked artery will be randomly assigned to one of two standard techniques: a cyclic 'plunger' method or a steady suction method. The goal is to see …

This study tests whether a personalized weaning strategy can help adults with chronic heart, brain, or lung conditions leave ventilators earlier. The strategy tailors care based on the main reason a patient struggles to breathe on their own, such as heart or muscle problems. Rese…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests two traditional Chinese medicines, Dengzhan Xixin and Dengzhan Shengmai, in 358 adults who recently had an ischemic stroke. The goal is to see if these treatments improve recovery and reduce disability at 3 months. Researchers will also study how the medicines wo…

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests whether adding alirocumab (a cholesterol-lowering injection) to standard statin therapy can reduce bleeding inside fatty plaques in the carotid artery. About 280 people with a recent mini-stroke or stroke due to a 50-69% blocked neck artery will receive either al…

This study tests a new device called the iNstroke 5F catheter to remove blood clots in people having an acute ischemic stroke. The goal is to see if it can safely restore blood flow to the brain within 24 hours of symptoms starting. About 45 adults with moderate to severe strokes…

This pilot study will test whether a virtual reality (VR) rehab program done at home can help people recover movement and thinking skills after a stroke or with Parkinson's disease. Sixty participants will either use a VR headset for daily exercises or receive standard rehab. The…

This study tests a traditional Chinese medicine mixture (red ginseng, notoginseng, and rhubarb) to help people recover from a hypertensive brain bleed without surgery. About 902 participants will receive either the herbal mix or a placebo for 28 days, alongside standard care. The…

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study looks at whether giving a low-dose aspirin just 2 hours after clot-busting treatment for stroke is better than waiting the standard 24 hours. About 210 adults aged 18-65 who had a stroke will be randomly assigned to get aspirin early or at the usual time. The goal is t…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The treatment uses blood pressure cuffs on the arms and inflatable leg sleeves to temporarily reduce blood flow in the limbs, which may trigger the body to …

This study tests whether using a balloon guide catheter during carotid artery stenting can prevent small particles from traveling to the brain and causing strokes. About 126 people with narrowed neck arteries will be randomly assigned to receive the balloon protection or standard…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This phase II trial tests whether adding bosentan to standard steroid treatment helps people with giant cell arteritis (GCA) avoid relapses and reduce steroid use. About 40 adults with GCA will receive either bosentan plus steroids or steroids alone for 3 months, then be followed…

This study tests whether a smartphone-supported care program can improve health outcomes for stroke patients who have trouble swallowing. The program includes diet monitoring, doctor communication, and education. Researchers will compare 600 patients who receive this enhanced sup…

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This trial tests a new stent called SILANCE for people with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull causes severe headaches, ringing in the ears, and vision problems. The stent is placed in a narrowed vein in the brain to impro…

This study tests whether people with giant cell arteritis (GCA) can safely take steroids for only 8 weeks instead of the usual 26 weeks when also using the drug tocilizumab. About 178 participants will be randomly assigned to one of two treatment lengths. The goal is to see if th…

This early-phase study tests whether a drug called Tenecteplase (TNK) is safe to inject directly into a brain bleed (intracerebral hemorrhage). Five adults aged 18-80 with large bleeds will receive a single dose during standard surgery. The goal is to see if TNK can dissolve the …

This study tests a device called I-NIC that uses low-frequency magnetic pulses to treat people who have had a stroke. The goal is to see if it helps improve recovery when used alongside standard care. About 364 participants will receive either the real device or a placebo for 5 d…

This early-stage study tests the safety of a drug called pegcetacoplan (Empaveli) in 20 adults who have had a stroke from a large clot and already had a procedure to remove it. The drug aims to reduce swelling and inflammation that can occur when blood flow returns. Participants …

This study tests whether a virtual reality (VR) home exercise program can help stroke survivors improve arm and hand function. Forty-eight adults who had a stroke at least 3 months ago will either use a VR headset to practice daily activities at home or receive standard therapy. …

This study tests whether a minimally invasive procedure called endovascular treatment can help people who have a progressive stroke caused by a blockage in the main artery at the back of the brain. The procedure uses a catheter to remove or open the clot. The trial will include 2…

This study tests whether cooling the brain with cold saline during clot-removal surgery helps people recover from severe strokes. About 322 adults with large strokes will be randomly assigned to get standard care or standard care plus local brain cooling. The main goal is to see …

This study tests whether giving a drug called tirofiban directly into the artery right after a clot is removed can help people recover better from a severe stroke. About 344 adults who had a large-vessel blockage stroke will be randomly assigned to receive the drug or not. The ma…

This study tests a special balloon coated with medicine to open narrowed arteries in the brain and prevent strokes. About 264 people with severe artery narrowing will be treated and followed for 12 months. The goal is to see if the balloon is safe and keeps arteries open better t…

This study tests whether removing blood clots from brain veins (endovascular thrombectomy) plus standard blood thinners works better than blood thinners alone for people with severe cerebral venous sinus thrombosis (CVST). The trial will include 440 adults at high risk of poor ou…

This study tests whether giving a large amount of IV saline (about 2-2.5 liters) right after clot-busting treatment helps people recover from a stroke better than giving only a small amount. The trial will enroll 752 adults aged 18-80 who had an ischemic stroke and received throm…

This study tests whether managing blood pressure based on the brain's collateral circulation (backup blood flow) after stroke treatment leads to better recovery. About 544 adults who had a stroke due to a large artery blockage and received endovascular therapy will be enrolled. P…

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

This study tests whether the clot-busting drug tenecteplase can improve recovery in people with acute ischemic stroke when given 4.5 to 9 hours after symptoms start. It uses a special MRI pattern (DWI-FLAIR mismatch) to identify patients who might still benefit. About 564 adults …

This study tests a simple, non-invasive treatment called remote ischemic conditioning (RIC) for people who have had a stroke and also developed heart muscle injury. RIC involves using a blood pressure cuff on the arm to briefly restrict blood flow, which may trigger the body's ow…

This Phase 3 trial tests a new injectable drug, ongericimab, in about 4,800 people who recently had a stroke due to narrowed arteries. The goal is to see if lowering LDL cholesterol more than current standard care can prevent future strokes, heart attacks, or death from heart dis…

This study looks at stroke patients who have small clots remaining in smaller brain arteries after the main clot has been removed. Half will get an extra procedure to remove those leftover clots, while the other half will receive standard care without extra intervention. The goal…

This study tests whether a drug called edaravone dexborneol can help people who have a stroke while also having active cancer. The drug is given by IV twice a day for 10-14 days. Researchers will check if it improves recovery and is safe. About 144 adults aged 18-80 will take par…

This study tests whether the drug butylphthalide can reduce brain swelling in people who have had a severe stroke and undergone a procedure to reopen a blocked artery. About 100 adults will receive either the drug or a placebo for up to 14 days. Researchers will measure changes i…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This study tests whether two dietary supplements—tauroursodeoxycholate (a bile acid) and a traditional Chinese medicine formula—can help people with diabetic macular edema, a vision-threatening complication of diabetes. The 69 participants will take the supplements or a placebo f…

This study tests whether the anti-inflammatory drug ulinastatin can prevent strokes in people having brain tumor removal. About 1,370 patients will receive either ulinastatin or a placebo before and after surgery. The goal is to see if the drug lowers the chance of having a strok…

This study will compare the safety of two clot-dissolving drugs, rhTNK-tPA and rt-PA, in 4500 adults having an acute ischemic stroke. Researchers will track how often each drug causes serious bleeding in the brain within 36 hours. The goal is to see if the newer drug, rhTNK-tPA, …

This study tests a device that uses sound waves (lithotripsy) to break up calcium buildup in the carotid arteries—the main arteries in the neck—before placing a stent to keep them open. The goal is to see if this approach reduces complications like stroke, heart attack, or death …

This study looks at whether using a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The study will involve 8…

This early study tests whether a drug called RK-4 can be safely injected through the skull into the brain of people having a severe stroke. Only 6 participants will receive the injection once a day for 3 days, using a special device. The main goal is to see if the procedure is fe…

This phase 2 trial tests whether the drug J147, given by IV after clot removal, helps people recover from an acute ischemic stroke. About 196 participants will receive either J147 or a placebo. Researchers will measure brain function and safety through MRI scans and blood tests o…

This study tests a smartphone app called StrokeApp designed to support people after a stroke or mini-stroke. The app provides educational content, medication reminders, and tools to track health. Researchers will compare quality of life and other health measures between 500 patie…

This study tests a new device that uses sound waves (lithotripsy) to break up hard calcium deposits in the carotid arteries of the neck before placing a stent. About 185 people with heavily calcified carotid arteries will be enrolled. The main goal is to see if the procedure is s…

This study tests whether canagliflozin, a diabetes drug, can reduce dangerous brain swelling and bleeding in people who have had a severe stroke and are receiving clot-removal therapy. About 150 adults will be randomly assigned to take the drug for 14 days or receive standard car…

This phase 2 study will test how the drug sildenafil (Revatio) is processed in the bodies of 24 full-term newborns who experienced oxygen deprivation at birth and are already receiving standard cooling therapy. The goal is to measure drug levels and prepare for a larger trial tha…

This study tests whether adding a drug called human urinary kallidinogenase to standard clot-busting therapy can improve recovery after a stroke. About 220 adults who have had a moderate stroke will be randomly assigned to receive the combination or standard care alone. The main …

This study compares transfusions using red blood cells from umbilical cord blood versus standard adult donor blood in extremely premature infants. About 176 babies born before 28 weeks or weighing under 1000 grams will be enrolled. The goal is to see if cord blood reduces the ris…

This study looks at whether starting insulin to lower high blood sugar on day 4 after a severe stroke is better than starting on day 1. About 200 adults with severe stroke and high blood sugar will be randomly assigned to early or delayed treatment. The goal is to see if delaying…

This study compares two approaches for people who have had a stroke or mini-stroke due to a blocked brain artery that hasn't opened on its own. One group gets a procedure to reopen the artery plus medication, while the other gets medication alone. The goal is to see which approac…

This study tests a new approach for people with a serious type of brain bleed (lobar intracerebral hemorrhage). It combines a highly precise, computer-guided surgery to drain the blood with a clot-busting drug called tenecteplase. The goal is to see if this treatment helps more p…

This study tests a drug called tirofiban (Aggrastat) in 82 people who have had bleeding from a brain aneurysm. The drug is given through a vein to prevent blood clots that can cause delayed brain damage. The main goal is to find the safest dose, while also checking if it reduces …

This study compares two medical devices used to close a small hole in the heart called a PFO, which can cause strokes. About 1,260 adults who have had a stroke or mini-stroke in the past year will be randomly assigned to receive either the Cocoon PFO Occluder or the Amplatzer PFO…

This study tests whether giving the drug tenecteplase directly into the brain's arteries, along with standard care, helps people recover better after a stroke caused by a medium-sized blood clot. About 488 adults with stroke symptoms starting within 24 hours will take part. The g…

This study tests a one-time procedure done before birth to treat a rare brain blood vessel problem called vein of Galen malformation. The treatment blocks abnormal blood flow while the baby is still in the womb, at or after 34 weeks of pregnancy. About 20 fetuses will be treated,…

This study tests a wireless brain-computer interface implanted in the skull to help people who had a stroke regain arm movement. Ten participants will undergo intensive rehabilitation with and without the device. The main goal is to check safety, but researchers will also measure…

This study is testing whether the clot-busting drug tenecteplase is safe and effective for people aged 80 and older who have had a stroke. Researchers will track 392 patients to see how well they recover and if there are any serious side effects. The goal is to find out if this t…

This study tests whether a clot-dissolving drug called tenecteplase works better than standard antiplatelet pills for people who have a mild but disabling stroke caused by a large blocked artery. About 864 adults who arrive at the hospital 4.5 to 24 hours after symptoms start wil…

This study tests a medicine called tenecteplase for people who have a stroke but don't know exactly when it started, like waking up with symptoms. About 352 adults will get either tenecteplase or standard care after a simple CT scan. The goal is to see if the drug helps them reco…

This study will test a special coil called the Penumbra PC400 in 100 adults aged 18 to 80 who have a medium or large brain aneurysm (5 mm or bigger). The coil is placed inside the aneurysm to block blood flow and prevent rupture or rebleeding. Researchers will track how well the …

This study will test a combined procedure in 150 people with atrial fibrillation (AFib) who are at risk for stroke. Doctors will use pulse field ablation to correct the heart's rhythm and then close off a small pouch in the heart (the left atrial appendage) to prevent blood clots…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery can help stroke patients who still have blocked blood flow after a standard clot removal procedure. About 344 adults with a major stroke will be randomly assigned to receive eit…

This study compares two blood thinners—apixaban (Eliquis) and warfarin (Coumadin)—in 460 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents strokes, pump clots, and serious bleeding. Participants must have had their…

This study tests whether sending people with suspected severe stroke directly to the angiography suite (instead of first getting a CT or MRI) can speed up treatment and improve recovery. About 568 adults with stroke symptoms within 6 hours will be randomly assigned to the direct …

This Phase 1 trial will test the safety of PRO-169, a form of bevacizumab injected into the eye, in 60 adults with diabetic macular edema. The study checks for immune reactions and side effects. It is not yet recruiting and focuses on safety, not whether it improves vision.

This study tests whether a single injection of Recaticimab, a cholesterol-lowering drug, can help people recover better after a stroke caused by narrowed brain arteries. About 1,200 participants will receive either the drug or a placebo, plus standard care. The main goal is to se…

This study tests an oral medication, CU06-1004, for people with diabetic macular edema (DME), a condition that causes vision loss. About 156 participants will take either a low dose, high dose, or placebo pill daily for 24 weeks. The goal is to see if the drug improves vision and…

This study tests whether adding the anti-inflammatory drug baricitinib to standard clot-removal treatment helps people recover better after a severe stroke caused by a blocked artery in the front of the brain. About 750 adults will receive either baricitinib or a placebo for five…

This study tests whether an interactive virtual reality (VR) system, where patients move to play games, can improve arm and leg function better than just watching VR. Sixty adults recovering from a stroke or traumatic brain injury will use the VR system three times a week for eig…

This study compares a combination of a steroid implant (dexamethasone) plus an anti-VEGF injection (aflibercept) against aflibercept alone for diabetic macular edema. Researchers will enroll 114 people with diabetes who have not had prior treatment. The goal is to see if the comb…

This study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people who have had a brain hemorrhage (a type of stroke) recover better and avoid future heart attacks or strokes. About 1,125 adults with signs of artery disease will take either colchicine or…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests whether the drug anakinra can limit brain damage in people who have had a severe stroke and have already undergone a procedure to remove a blood clot. About 159 adults aged 18-80 will receive either standard care or anakinra at different doses. The main goal is t…

This early-phase trial tests whether adding hydrogen gas to standard cooling therapy is safe and feasible for newborns who suffered brain injury from lack of oxygen at birth (HIE). About 54 infants will be randomly assigned to receive either standard cooling alone or cooling plus…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This trial tests an artificial intelligence system called QiLin that helps doctors decide when to give anti-VEGF injections for retinal diseases like wet AMD, DME, and RVO. About 200 patients who have completed initial treatment will be randomly assigned to have their doctor use …

This study tests a new type of ultrasound that can see through the skull to find tiny metal pieces left after brain aneurysm surgery. About 78 adults who had aneurysm clipping will get this ultrasound within 3 hours after surgery, along with a standard CT scan. The goal is to see…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This study will test a new radioactive tracer called FBFP in 30 stroke patients and 20 healthy volunteers. The tracer is used with a PET/MR scanner to take detailed pictures of the brain. The goal is to see if FBFP can help doctors diagnose and understand stroke better. Participa…

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study tests an artificial intelligence system designed to automatically score disability after a stroke using the Modified Rankin Scale. Researchers will compare the AI's scores to those from trained clinicians in 490 stroke patients. The goal is to see if the AI can provide…

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This study will check if an artificial intelligence (AI) system can accurately score stroke severity as well as a trained doctor. About 297 adults with a recent stroke will have their speech and facial movements recorded. The AI will analyze these recordings to produce a G-FAST s…

This early-phase trial tests whether a fluorescent dye called LUMISIGHT (pegulicianine) can light up inflammation in artery plaques removed during surgery. Inflammation is a key driver of heart attacks, but current imaging can't see it clearly. Researchers will compare the dye to…

This study aims to see if two new web-based tests (star cancellation and line bisection) can accurately detect visuospatial neglect—a condition where stroke survivors ignore one side of space. About 105 adults who had a stroke will take both digital and traditional paper versions…

This study looks at how quickly the optic nerve sheath shrinks after starting steroids in people with giant cell arteritis, a condition that can cause blindness. Researchers will use eye ultrasounds and blood tests over two months in 60 newly diagnosed patients. The goal is to fi…

This study will develop and test an artificial intelligence system to detect common eye diseases like glaucoma, cataracts, and diabetic retinopathy using 15,000 existing eye images from Costa Rican patients. The goal is to create a tool that works accurately for local populations…

This study will test a new rapid blood test that can be done at the bedside to help doctors quickly tell if a child is having a stroke. About 250 children with stroke symptoms will give a small blood sample, and the test's accuracy will be compared to standard brain scans. The go…

This study looks at whether a detailed MRI of the blood vessel wall can help doctors tell the difference between two common causes of stroke: hardening of the arteries (plaque buildup) and inflammation of the vessel wall (vasculitis). About 46 people who recently had a stroke wil…

This study tests whether a single injection of fremanezumab, a drug used to prevent migraines, can stop acute mountain sickness (AMS) in healthy adults. Thirty volunteers will receive either the drug or a placebo one week before climbing to a high-altitude hut. Researchers will t…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This study tests whether the drug cilostazol can prevent recurrent strokes and heart problems in 1100 recent stroke survivors in Ghana. Participants take either cilostazol or a placebo twice daily for 24 months. The goal is to see if this affordable drug, already used in Asia, ca…

This study tests whether a structured referral tracking program helps adults in Pakistan complete follow-up eye care after community screenings. 500 participants will receive either standard referral or extra support like counseling and weekly reminders. The goal is to prevent bl…

This study compares two ways of feeding patients with severe ischemic stroke who have trouble swallowing. The goal is to see if feeding through a tube placed past the stomach (post-pyloric) reduces the chance of developing pneumonia compared to standard stomach feeding. About 174…

This study tests whether a tablet called edaravone dexborneol can prevent epilepsy in people who have had a stroke and are at high risk. About 160 adults will receive either the tablet or a placebo for three months, starting within 48 hours of their stroke. Researchers will track…

This study tests whether giving a calcium channel blocker (nicardipine) through a lumbar drain can prevent dangerous artery spasms and delayed brain damage in people who have had a brain bleed from a ruptured aneurysm. About 214 adults with mild to moderate bleeds will receive th…

This study tests a new way to help young people (ages 13-24) stick with PrEP, a medication that prevents HIV. Participants get PrEP delivered to a community spot (like home or a mobile van) and use a smartphone app for reminders and support. The goal is to see if this combo impro…

This early study tests the safety of a 7-day intravenous drip of propranolol (a drug usually used for heart conditions) to prevent pneumonia in 30 adults who have had a severe brain bleed. The goal is to find the best dose and see if it reduces lung infections. Participants must …

This study tests whether kangaroo care (skin-to-skin contact with a parent) can reduce the risk of severe brain bleeding in extremely preterm newborns. About 314 babies born at 28 weeks or earlier will be randomly placed in a side-lying kangaroo position, a prone kangaroo positio…

This phase 3 trial will test whether a low dose of the blood thinner rivaroxaban plus aspirin can prevent recurrent strokes better than the standard clopidogrel plus aspirin in people with narrowed brain arteries. About 1,172 participants who recently had a stroke or high-risk TI…

This study tests whether adding a very low dose (15 mg) of the blood thinner edoxaban to standard aspirin or clopidogrel can prevent repeat strokes in people aged 75 and older who have already had an ischemic stroke. About 1,200 participants will be randomly assigned to receive e…

This study tests whether an electronic alert in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goa…

This study tests whether giving a mild electrical brain stimulation (tDCS) before, during, or after physical therapy helps stroke patients recover arm movement faster. Sixty hospitalized stroke survivors will receive three daily tDCS sessions, with only one being real and the oth…

This phase 3 study evaluates the long-term safety of elismetrep (K-304), an oral medication taken as needed for migraine attacks. About 1,000 adults who previously took elismetrep in an earlier trial will continue using it intermittently. Researchers will track side effects over …

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This study tests whether special attention exercises can improve focus and quality of life in people who have had a stroke. 46 participants will do either attention training or standard rehab for 4 weeks. Researchers will measure changes in attention and daily functioning.

This pilot study tests whether eye movement training can help people who lost part of their vision after a stroke. Twenty participants will either use an eye-tracking machine in the clinic or do reading exercises at home. Researchers will measure changes in eye movements and read…

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This study compares three different walking training programs for people recovering from a stroke. Twenty participants will be randomly assigned to moderate-intensity walking, high-intensity walking, or high step-count walking during their inpatient rehab. The goal is to see whic…

This study tests a home-based eye movement therapy (optokinetic stimulation) for people with spatial neglect after a stroke. Spatial neglect makes it hard to pay attention to one side of the world, often leading to falls. The therapy involves watching moving dots on a computer sc…

This study will test two FDA-approved migraine drugs, rimegepant (a tablet that dissolves on the tongue) and zavegepant (a nasal spray), in 100 adults visiting the emergency department for a migraine. The goal is to see if these drugs provide pain relief within 2 hours without ne…

This study tests whether neurofeedback—a type of brainwave training—can help adults with episodic migraine have fewer and less severe headaches. Participants will undergo 60 sessions over 12 weeks, learning to regulate their brain activity through real-time feedback. The goal is …

This study investigates whether sleeping on a gently rocking bed can improve sleep quality and memory in people undergoing neurorehabilitation after conditions like stroke, traumatic brain injury, or inflammatory diseases of the central nervous system. Participants will sleep on …

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This study tests a physiotherapy program that combines neck muscle exercises with a gentle nerve stimulation technique (transcutaneous vagus nerve stimulation) in 50 adults with migraine. The goal is to see if this approach can reduce pain, improve daily function, and boost quali…

This study tests a special acupuncture technique called 'Nine Pharyngeal Acupoints' to help stroke patients who have trouble swallowing. The goal is to see if it improves their ability to eat and drink safely. Researchers will use muscle activity tests and video X-rays to measure…

This study tests a new type of physical therapy called NICE rehabilitation for people who have had a stroke and have weakness on one side. The therapy uses a computer to show patients how to activate specific muscles, helping them regain arm movement. Researchers will measure cha…

This study tests whether a quick, gentle push on the lower back (called lumbar spinal manipulation) can improve balance and lower fall risk in people who have had a chronic stroke. Fifty-two participants will receive both the real manipulation and a placebo version at different t…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study tests a virtual behavioral program for people with chronic migraine. Researchers want to find the best combination of techniques and see if letting patients choose their treatment helps. The goal is to reduce migraine frequency and intensity.

This study tests whether eptinezumab, a drug used for migraines, can reduce the number of headache days in adults with idiopathic intracranial hypertension (IIH), a condition where high fluid pressure around the brain causes severe headaches. About 96 women aged 18-55 with chroni…

This study tests whether a non-invasive technique called transcranial focused ultrasound can help stroke survivors recover movement and thinking skills. Researchers will use brain scans and EEG to guide stimulation to specific areas. 60 adults who had a first stroke within the la…

This study looks at whether combining Frenkel exercises (repetitive movements to retrain the brain) with electrical muscle stimulation can improve balance, coordination, and body awareness in people who have had a stroke. About 38 adults aged 50-65 who can walk independently will…

This study tests whether an 8-session self-hypnosis program, delivered online in groups, can help adults with migraines reduce disability and improve well-being. Forty participants are randomly assigned to either the hypnosis training or a waitlist. The program teaches self-hypno…

This study will test a comfortable, soft elbow brace that helps bend and straighten the arm, along with a vibrating forearm bracelet that gives touch cues. About 45 people with stroke or Parkinson's disease will try these devices during arm exercises. The goal is to see if the de…

This study tests a robotic device designed to help people with stroke, Parkinson's disease, ALS, or mild cognitive impairment improve their arm and hand function. Thirty adults will receive standard rehabilitation, and half will also use the robot for up to 30 minutes per session…

This study tests whether adding fire needling (a technique using heated needles) to standard acupuncture can better reduce headache days in people with both chronic migraine and tension-type headache. Eighty-eight adults will receive either the combined treatment or acupuncture a…

This study tests if a procedure called middle meningeal artery embolization can help people with frequent migraines. The procedure uses tiny coils to block a blood vessel in the head. Researchers want to see if it reduces migraine days and the need for migraine medications. The s…

This study looks at whether anti-IL-6 drugs, used for inflammatory conditions like rheumatoid arthritis, can also reduce migraine frequency and intensity. Researchers will compare 320 people taking anti-IL-6 drugs to those on anti-TNF drugs. Participants will report how their mig…

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This study tests a 6-week program where stroke survivors do balance exercises while also performing mental tasks, like naming words or reacting to sounds. The goal is to see if this dual-task training improves stability and mobility better than standard balance exercises alone. 2…

This pilot study tests whether watching special videos can help people recover leg movement after a stroke. Twelve participants will use a video system that shows their good leg moving, while they try to copy the movement with their affected leg. They will do this 5 times a week …

This study tests whether combining augmented reality (AR) balance exercises with a gentle brain stimulation technique (tDCS) can improve balance and movement in people who have had a stroke. About 28 chronic stroke survivors with balance issues will be split into two groups: one …

This study tests if a non-invasive device that stimulates the vagus nerve can improve blood flow in the brain and thinking skills in people who had a stroke 6-12 months ago. Forty participants aged 50-60 with mild cognitive issues will receive the stimulation. Researchers will me…

This study tests whether combining virtual reality games with physical therapy can reduce chronic pain in children aged 7 to 21. Twenty participants with pain in the head, neck, or upper limbs will attend six weekly sessions. They will play VR games designed to encourage movement…

This study looks at people with migraines who also have a small hole in the heart (PFO). Participants first take a blood-thinning drug (prasugrel) to see if their migraines improve. Those who respond are randomly assigned to either continue the drug alone or have a procedure to c…

This study tests whether combining neuromuscular electrical stimulation with upper limb nerve exercises can improve hand grip strength and range of motion in people who have had a stroke. The trial will include 44 adults who had an ischemic stroke at least 3 months ago and have s…

This study tests if a new dynamic compression device, used with compression stockings, works as well as current treatments for reducing leg swelling in people with lymphedema. About 98 adults with stage II or III lymphedema will use either the new device or standard wraps and pum…

This early study tests a robotic leg brace with smart software that senses how a person walks and adjusts its help in real time. Researchers want to see if this adaptive system improves walking speed and balance in stroke survivors compared to a standard brace. About 20 people, i…

This study looks at whether a gait training program delivered partly at home using a sensor and exercises is feasible and acceptable for people who have had a stroke. Twelve participants in Saudi Arabia will first train in a clinic, then continue at home for four weeks. The goal …

This study compares a new dynamic compression device to traditional bandages for reducing leg swelling in people with lymphedema. Over 5 days of intensive treatment, 110 participants will wear either the device or standard bandages. The goal is to see which method reduces excess …

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This trial tests whether adding a structured home exercise program to regular clinic-based physical therapy helps people aged 40-50 with sub-acute stroke walk better and do daily activities. 72 participants will either get clinic rehab alone or clinic rehab plus home exercises li…

This study tests whether a virtual reality (VR) mindfulness program can help reduce anxiety in people who have had a stroke. About 48 adults who had a stroke more than 6 months ago and still feel anxious will use a VR headset for 9 sessions over 3 weeks. The goal is to see if thi…

This pilot study tests a new rehab program for people recovering from a stroke. The program combines walking exercises with mental tasks, like counting backwards or stepping over obstacles. Researchers want to see if it's safe, doable, and helps improve walking in real-world situ…

This pilot study tests whether individually tailored, non-invasive brain stimulation (high-definition tDCS) can improve arm function in 16 chronic stroke survivors when combined with rehabilitation therapy. Participants will receive either real or sham stimulation alongside modif…

This study looks at whether clenching your jaw can immediately improve walking and movement in people who had a stroke at least six months ago. Thirty participants will either clench their teeth on cotton rolls or keep their jaw relaxed, then take walking and balance tests. The g…

This study tests whether a gentle electrical current applied to the brain (tDCS) combined with hand exercises can improve hand function in people who had a stroke. Fifty-six participants will receive either real or sham tDCS for 20 sessions over four weeks. Researchers will use M…

This study tests a type of physical therapy called PNF (proprioceptive neuromuscular facilitation) for people who have had a stroke. The therapy uses specific leg exercises to improve balance, walking, and daily function. Sixty adults aged 40-80 who can walk with or without help …

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This study tests whether a virtual home rehabilitation program helps stroke survivors in underserved Texas communities recover better than standard care alone. About 80 adults who recently had a stroke and are returning home will take part. The program uses video sessions to guid…

This study tests a stepped-care model to support relatives of people with acquired brain injury or malignant brain tumor. The model offers basic support to all, with extra help for those who need it, based on screening. Researchers will measure changes in caregiver burden and wel…

This study tests whether using a virtual reality headset to practice a type of mindfulness therapy called Acceptance and Commitment Therapy (ACT) can reduce migraine-related disability. About 160 adults with episodic migraine will either continue their usual care or add VR sessio…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study looks at whether adding a non-invasive brain stimulation technique called rTMS to standard physical therapy can help people with chronic stroke-related weakness improve their movement, balance, and quality of life. Twenty adults who had a stroke at least six months ago…

This study tests whether adding the drug dexmedetomidine during carotid artery surgery helps keep blood pressure more stable. About 44 adults having this surgery will be randomly assigned to receive either standard anesthesia alone or standard anesthesia plus dexmedetomidine. The…

This study tests whether a trained volunteer visiting a stroke survivor at home for 8 weeks can improve their ability to cope after hospital discharge. About 840 people who had a stroke and are returning home will either get this extra support or just their usual care. Researcher…

This study will test whether a daily aromatherapy massage, combined with a sensory stimulation program, can improve cognitive function in intensive care patients with brain injuries. Sixty adults on ventilators or oxygen will be randomly assigned to receive the treatment from a f…

This study tests whether a personalized robotic telerehabilitation program can help people recover arm movement after a stroke. Seventy participants will use a wearable robotic device with virtual reality exercises at home for 4 weeks, supervised remotely. The goal is to see if t…

This study tests whether adding brain-computer interface (BCI) training to standard early rehabilitation helps people recover arm and leg movement after an acute ischemic stroke. Sixty adults aged 18 to 80 with one-sided limb weakness will receive either standard rehab alone or s…

This study tests whether a nerve block injection at the back of the head can help people with migraine who overuse painkillers. The injection contains lidocaine and a steroid. 130 participants will receive either the active injection or a placebo. Researchers will track headache …

This study will monitor the safety and effectiveness of NURTEC ODT 75 mg (rimegepant) in 3000 Korean adults with migraine. Participants will take the drug as prescribed for acute attacks or prevention. Researchers will track side effects and how well the drug works, including pai…

This early-phase trial aims to see if taking a combination of three common drugs (Telmisartan, Metformin, and Cilostazol) can help chronic stroke survivors gain more movement in their arms and hands during robot-assisted therapy. Fifty adults who had an ischemic stroke at least s…

This study tests a new robot-based therapy designed to improve arm movement and sensation in people who had a stroke more than six months ago. The therapy focuses on helping the brain better process sensory information from the arm. The trial will include 109 participants and com…

This study tests if using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (like from a stroke or trauma). The goal is to see if this fun approach helps patients stick with their therapy, which could lead to better r…

This study tests whether combining two types of non-invasive brain stimulation (tDCS and TMS) can improve memory, thinking, and movement in people who have had a stroke. Twenty-four participants will receive either real or fake (sham) stimulation daily for one week. Researchers w…

This study compares standard hand-arm training with a version that also includes thinking tasks, like memory or attention exercises, for people recovering from a stroke. Twenty adults aged 40-70 with mild to moderate arm weakness will take part. The goal is to see if combining ph…

This study tests if adding dance therapy to standard physical therapy helps people with chronic stroke (at least 6 months after) improve their balance and walking. Sixteen participants will be split into two groups: one gets standard therapy plus dance, the other only standard th…

This study tests whether corrective exercises paired with rhythmic auditory stimulation (like music or beats) can improve balance, walking, and quality of life in people who have had a stroke. Thirty-two adults aged 40-60 with subacute ischemic stroke will participate. They will …

This study tests whether a new drug called NB001 can quickly stop migraine pain and other bothersome symptoms. About 120 adults with migraines will take different doses of NB001 or a placebo at the start of an attack. Researchers will check if pain and symptoms go away within 2 h…

This study tests whether a gentle, non-invasive electrical brain stimulation (tACS) can improve working memory in people who have memory problems after a stroke. 24 participants will receive either real or fake stimulation for 40 minutes a day for 5 days, alongside cognitive ther…

This study tests a new, non-invasive brain stimulation technique called kTMP to help improve arm and hand function in people who have had a stroke. One hundred adults with chronic stroke-related arm weakness will receive either active or sham stimulation over 18 weeks. The goal i…

This study tests whether osteopathic manipulation—gentle manual techniques on the neck and head—can reduce migraine pain and its impact on daily life. 45 adults with frequent migraines will receive the therapy. The goal is to see if this drug-free approach offers real relief.

This study tests three different types of tinted lenses—FL41 glasses, Biomedics55 contacts, and Altius grey-green contacts—to see which works best for reducing light sensitivity (photophobia) in people who get migraines or have other eye conditions. About 200 volunteers who have …

This study tests whether intensive music therapy can improve thinking skills like memory, attention, and decision-making in people recovering from a stroke. It will include 36 adults in Malaysia who had a stroke within the last 3 months and have mild to moderate cognitive problem…

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study tests whether a robotic arm exoskeleton, combined with standard physical therapy, can improve arm function in people who had a stroke at least six months ago. Sixty participants will do 15 sessions of robotic training plus 20 minutes of standard rehab. Researchers will…

This study will test a new type of rehabilitation robot that uses brain signals and mirror therapy to help stroke patients with arm weakness. The robot is non-invasive and designed to encourage the brain to re-learn movement. Researchers will enroll 40 adults aged 30 to 80 who ha…

This study tests whether applying gentle vibration to the bottom of the foot can improve walking speed and balance in people who have had a stroke. Fifty-eight participants will be randomly assigned to receive either real vibration or a placebo (no vibration) for 30 minutes a day…

This study looks at whether gentle foot massage (reflexology) can improve comfort and vital signs in newborns with brain injury from oxygen loss, who are receiving cooling treatment. About 84 stable newborns will either get standard care or standard care plus foot reflexology. Re…

This study tests whether deep friction massage can reduce muscle stiffness in the thigh (quadriceps) of people who had a stroke 1 to 6 months ago. Thirty adults will either receive the massage plus standard physiotherapy, or physiotherapy alone. Researchers will measure changes i…

This study tests whether combining Botox injections with a nerve block at the back of the head works better than either treatment alone for chronic migraine. About 90 adults with frequent migraines will receive one of the treatments or both. The goal is to see if the combination …

This study explores whether a non-invasive brain stimulation technique called tDCS can be practically used during routine speech therapy for people who have had a stroke and now have aphasia (trouble speaking or understanding language). Researchers will enroll 30 stroke survivors…

This study tests whether adding immersive virtual reality to stationary cycling, alongside standard physical therapy, can improve walking and balance in people who have had a stroke. Twenty-five adults who are at least six months post-stroke will take part. Researchers will compa…

This study tests if a treatment called extracorporeal shock wave therapy (ESWT) can reduce leg muscle stiffness and improve walking in people who have had a stroke. About 85 adults who had a stroke at least 3 months ago will get either real ESWT or a fake (sham) version, plus sta…

This study looks at whether low-volume high-intensity interval training (HIIT) on a recumbent stepper is safe and doable for people recovering from a stroke in a hospital rehab setting. Fifteen participants will try a 10-minute HIIT session, and researchers will track any side ef…

This study tests a new augmented reality system called MirrARm that uses a camera and screen to create a virtual mirror of a stroke survivor's unaffected arm, making it look like their affected arm is moving. The goal is to see if this high-tech approach improves arm and hand fun…

This study tests whether a home-based music program can improve attention and thinking speed in people who have had a stroke. About 36 Malaysian stroke survivors with mild to moderate cognitive issues will take part. They will use music exercises at home, with help from a caregiv…

This trial tests whether an intensive, personalized speech therapy program (ICAP) helps people with post-stroke aphasia communicate better and feel better. 334 adults who had a stroke at least 3 months ago will be randomly assigned to either ICAP (100 hours over 4 weeks) or stand…

This study tests whether a single session of a mental practice technique called PETTLEP-based Action Observation and Motor Imagery (AOMI) can immediately improve arm movement in stroke survivors. Participants will either watch and mentally rehearse a reach-to-grasp task or do a c…

This study tests whether virtual reality exercises can help people who had a stroke within the last three months improve arm and hand function and promote brain healing. Forty adults aged 50-65 will use a VR system alongside standard therapy. The goal is to see if VR can boost re…

This study will test a special moving platform combined with virtual reality to help people with neurological disorders like Parkinson's disease, stroke, ALS, or mild cognitive impairment improve their balance and movement. The platform moves in three directions and adapts exerci…

This study tests whether adding functional electrical stimulation (FES) to task-oriented training helps stroke survivors with arm spasticity regain more movement than training alone. All participants receive Botox for spasticity first. The trial will enroll 40 adults who have had…

This study tests whether a non-invasive treatment called focal vibration therapy can reduce shoulder pain in people who have had a stroke. Sixty chronic stroke survivors with shoulder pain will receive either real vibration or a sham procedure, plus standard rehab. The goal is to…

This study tests whether using immersive virtual reality (VR) games can improve thinking skills and daily independence in people who had a stroke 2-4 months ago. 22 participants will be randomly assigned to either VR training or standard paper-and-pencil exercises. The goal is to…

This study tests whether a fully virtual mindfulness program (BREATHE-HA) is feasible and acceptable for teens aged 12–17 with migraine. Participants will either join a 6-session mindfulness group or a headache education group, both delivered via telehealth. The goal is to see if…

This study compares two procedures—a nerve block and a pulsed radiofrequency treatment—to see which works better for people with chronic migraine. About 70 adults who have not found relief from standard treatments will take part. The goal is to reduce headache pain and improve qu…

This study tests whether a robotic arm trainer called BurtVision, which uses augmented reality games, can help chronic stroke survivors improve arm function. Thirty-eight participants will do 18 sessions of either one-arm tasks or a mix of one-arm and two-arm tasks. The goal is t…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study tests whether a device that sends specific electromagnetic fields can help people who had a stroke more than 6 months ago improve arm function. 25 adults aged 18-80 with moderate arm weakness will use the device in clinic and at home for 3 months. The main goal is to s…

This study will test whether different frequencies of electroacupuncture (low, medium, or high) can improve swallowing problems in 90 stroke survivors. Participants will receive daily 30-minute sessions over several weeks. The goal is to find the best frequency and understand how…

This study tests a personalized brain stimulation technique called IAF-rTMS to help people recover movement after a stroke. Thirty-four adults who had a first ischemic stroke will receive either real or sham stimulation for two weeks each, in a crossover design. Researchers will …

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve naming ability in people who have trouble speaking after a recent stroke. Twenty-eight adults with aphasia will receive either real or sham stimulation over five days. The goal is to see if…

This study tests whether special balance exercises that target the inner ear (vestibular system) can help people who have had a stroke walk better and lower their risk of falling. About 40 adults who had a stroke at least 6 months ago will be assigned to either vestibular trainin…

This study tests whether a non-invasive, AI-powered brain stimulation technique can improve finger movement in people who had a stroke within the past 3 months. About 116 adults with arm and hand paralysis will receive either real or fake (sham) stimulation to see if the real tre…

This study will test if guided nature-based therapy, like forest bathing and gardening, can improve the wellbeing of elderly patients with dementia and patients recovering from stroke or brain injury. Researchers will measure changes in agitation, mood, and quality of life in 1,6…

This study tests whether a special augmented reality training program (AR-FIT) can improve balance and mobility in people who have had a stroke. Researchers will compare AR-FIT to standard therapy in 78 adults aged 40-70 who are at least 3 months post-stroke. The training involve…

This study compares two types of exercise—wobble board and Swiss ball—to see which better improves balance and stability in stroke survivors. About 38 people aged 40-60 who had a stroke more than 6 months ago will participate. The goal is to find a simple, effective way to reduce…

This study tests if using a cotton-tipped applicator to hold the eyelid open during eye injections is less painful and faster than the standard metal speculum. About 120 adults with certain eye conditions will take part. The goal is to improve comfort and satisfaction without com…

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control g…

This study tests whether a feeding tube placed in the upper esophagus (oro-esophageal) helps stroke patients with swallowing difficulties recover faster than the standard nasogastric tube (through the nose). The trial will include 422 adults who recently had a first ischemic stro…

This study tests whether a special suit that delivers mild electrical pulses can quickly reduce muscle stiffness and improve movement in people who have had a stroke. Twenty-six participants will wear the suit for one hour and be compared to a control group receiving minimal stim…

This study looks at whether yoga is a practical and helpful activity for adults who have had a stroke at least three months ago. Forty participants in Nova Scotia will try both virtual and in-person yoga classes twice a week for 90 minutes, plus one recorded session. Researchers …

This study tests whether adding a mild brain stimulation technique (tDCS) to a standard arm therapy (constraint-induced therapy) helps people who had a stroke more than therapy alone. Forty adults with chronic stroke and mild-to-moderate arm weakness will be randomly assigned to …

This study tests whether playing interactive games on a smart tablet can improve hand dexterity and strength in people who have had a stroke. Forty chronic stroke patients will either do tablet hand exercises plus standard physical therapy, or standard therapy alone. The goal is …

This study tests whether a hand-held mouth exercise device called IQoro can improve swallowing in 100 adults who have had a first stroke and now have trouble swallowing (dysphagia). Participants will either receive usual care or usual care plus daily IQoro training. The main goal…

This study tests a new robotic walking trainer called Rise&Walk InHome that stroke survivors can use at home. Twenty adults who had a stroke 3 months to 5 years ago will either use the device for 30 minutes, 4 times a week plus usual care, or just usual care. The goal is to see i…

This study compares two types of robotic hand therapy for people with chronic stroke and hand weakness. One group uses a robot that moves when the patient's brain waves show they are imagining the movement, while the other group uses a robot that moves automatically. The goal is …

This early-phase trial at Boston Children's Hospital will test whether adding virtual reality (VR) to standard treatments like biofeedback and cognitive behavioral therapy can help 12 adolescents with chronic dizziness. The goal is to see if VR can safely and feasibly reduce dizz…

This study compares a new 'one-stop' emergency stroke unit that combines CT scanning and treatment in one room to the usual process where scans and treatment happen in separate places. The goal is to see if this faster approach helps more people recover with little or no disabili…

This study tests whether combining two therapies—blood flow restriction training (using a cuff to partially restrict blood flow during exercise) and brain stimulation (rTMS)—can improve arm and hand function in people who have weakness on one side after a stroke. 69 adults will b…

This study tests whether adding an AI-driven virtual reality (VR) program to standard rehabilitation can improve arm movement in people who recently had a stroke. Fifty hospitalized adults with arm weakness will be randomly assigned to either standard rehab alone or standard reha…

This study tests a web-based program that combines physical exercises with brain games for people who had a stroke at least 6 months ago. Researchers want to see if it improves walking, balance, memory, and attention better than usual care. About 52 adults will be randomly assign…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This study tests whether a single session of sleep hygiene education can improve sleep quality and reduce pain in 100 adults with migraine or chronic lower back pain. Participants will learn healthy sleep habits and follow them for four weeks, tracking changes through questionnai…

This pilot study tests whether manual lymphatic drainage, a gentle massage technique, can help people with migraine. Twenty adults aged 20-55 who have at least 4 migraines per month will receive either the massage or standard care. Researchers will measure pain, disability, and q…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help people over 70 recover swallowing after a stroke. Twenty participants will receive either active or sham stimulation alongside standard speech therapy for three weeks. Researchers wi…

This study tests whether playing specially designed video games (exergames) can help people with chronic stroke improve arm movement and quality of life better than standard home exercises. About 32 adults who had a stroke more than 6 months ago will be randomly assigned to eithe…

This study tests whether watching moving bars on a screen through virtual reality glasses can help stroke patients who have spatial neglect — a condition where they ignore one side of their world. Thirty patients aged 50-65 will receive five 4-minute sessions of this visual stimu…

This study compares two therapies—neuromuscular electrical stimulation (NMES) and EMG biofeedback—for treating shoulder subluxation in stroke survivors. Thirty-six participants will receive one of the therapies plus standard physiotherapy for three weeks. The goal is to see which…

This study tests whether augmented reality (AR) can help people who have had a stroke walk with more balanced steps. Twenty adults who had a stroke within the past 6 months will try two types of visual feedback—an avatar and simple bars—while walking in a long hallway. The goal i…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study will use ultrasound to measure the thickness and movement of breathing muscles between the ribs in 65 stroke patients. Researchers will compare the affected and unaffected sides and see how these measurements relate to breathing strength, movement, balance, and quality…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This trial tests an AI tool called MIDI that quickly spots problems in brain MRI scans. The goal is to see if it helps doctors report urgent scans faster, so patients get treatment sooner. Over 100,000 adults will take part across multiple NHS sites in the UK.

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

This study will test a device that delivers gentle waist pulls during treadmill walking to improve balance in people who have had a stroke and in older adults with mild balance issues. Fifty participants will undergo nine training sessions over three weeks. The goal is to see if …

This study aims to learn how patients with severe stroke move during their hospital stay. Fifty adults will wear a small activity tracker (activPAL) that records lying, sitting, standing, and stepping. Researchers will compare this data with standard mobility goals to understand …

This study investigates why some chronic stroke survivors with slow walking speed improve after high-intensity interval training (HIIT) while others do not. Participants will undergo 12 weeks of supervised cycling sessions, along with MRI brain scans and walking tests before and …

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will test whether using ultrasound to guide how a patient's head is tilted can improve blood flow to the brain. Researchers will measure brain pressure and blood flow in 30 ICU patients as they are moved from lying flat to a 30-degree angle. The goal is to find a perso…

This study will measure certain proteins in the blood of people who have had a brain hemorrhage (bleeding in the brain) and compare them to healthy volunteers. The goal is to see if these proteins are linked to inflammation after the bleed. No drugs or treatments are being tested…

This trial aims to see if educational videos or audio messages can improve parents' knowledge and practices about retinopathy of prematurity (ROP) screening. About 99 parents of premature infants in Karachi will receive either a video, audio, or standard pamphlet. Their understan…

This trial tests whether remifentanil or esmolol is better at preventing dangerous pressure spikes in the brain when a breathing tube is inserted. Patients with unruptured brain aneurysms scheduled for coil embolization will receive one of the two drugs before intubation. Researc…

This study looks at whether a type of immune cell called regulatory T cells works properly in people with chronic migraine. Researchers will compare blood samples from 24 women with chronic migraine to healthy controls. The goal is to understand if problems with these cells contr…

This study collects a wide range of information from stroke survivors and healthy volunteers, including genetic data, brain scans, electrical brain activity, and thinking and memory tests. The goal is to build a model that can predict which stroke survivors are most likely to dev…

This study will look at how balance, arm movement, and body awareness are related in 53 people who had a stroke at least 6 months ago. Participants will complete tests like standing on a special platform, reaching tasks, and questionnaires. The goal is to understand these connect…

This study tests whether a 6-week program that combines a pedometer with phone or video coaching is practical for people who had a stroke at least 6 months ago. 24 participants will track their steps and set goals with an occupational therapist. The main goal is to see if people …

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study will compare how young adults, older adults, and stroke survivors sense small electrical pulses on their skin. Researchers will measure the smallest changes in pulse frequency, strength, and timing that people can detect. The goal is to gather basic information to impr…

This study follows 50 adults with migraines who have had or plan to have a procedure called middle meningeal artery embolization as part of their regular care. Researchers will look at how headache frequency, severity, medication use, and quality of life change over 12 months. Th…

This study will collect blood samples and medical information from 600 adults with rare diseases affecting blood vessels in the brain and eye, such as CADASIL and cavernous angioma. The goal is to create a long-term biobank that researchers can use to find biomarkers and better u…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study will use a special scan to look for B cells (a type of immune cell) in the blood vessels of 30 people with giant cell arteritis, a serious disease that can cause blindness or stroke. Current treatments rely on steroids, which have harsh side effects. If the scan works,…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This observational study will follow 2,500 people who had a brain hemorrhage and received minimally invasive surgery. Researchers want to see how well patients recover in real-world settings. The study does not test a new drug or procedure, but gathers data to improve future care…

This pilot study will test if training hospital staff in low-resource settings helps them follow a standard stroke care plan. The study plans to enroll 300 adults with acute stroke in hospitals with limited resources. Researchers will measure how well staff stick to the care plan…

This study tests a simple screening tool to help doctors find muscle stiffness (spasticity) sooner after a stroke. Researchers will track how quickly spasticity is detected and whether the tool helps doctors make faster treatment decisions. About 80 adults who recently had a stro…

This study looks at whether having physical therapy (PT) and occupational therapy (OT) together in one session works as well as having them separately for stroke patients in the hospital. About 567 adults admitted for acute stroke will be randomly assigned to either co-treatment …

This study tests whether a video camera with artificial intelligence can track newborn brain health by analyzing their movements. About 200 babies in the NICU will be recorded continuously from admission to discharge. The AI's findings are kept from doctors for now, to see if the…

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This study looks at whether using a 3D-printed copy of a patient's brain aneurysm can help doctors plan treatment and avoid problems. About 40 adults with unruptured aneurysms will have their aneurysm printed from scans, then doctors will practice the procedure on the model befor…

This study uses a non-invasive forehead sensor to continuously monitor brain oxygen levels in 120 patients with subarachnoid hemorrhage (a type of stroke caused by bleeding around the brain). The goal is to see how the brain's ability to regulate blood flow changes over time and …

This study will track 1000 adults who had a brain bleed from a burst aneurysm. The goal is to learn how often delayed brain injury happens and how doctors currently diagnose and treat it. By comparing different hospital approaches, researchers hope to find better ways to prevent …

This study tests whether a one-week educational campaign called SURA'A can improve how adults recognize stroke symptoms and their intention to seek emergency help. Researchers will enroll 350 adults at primary health centers in Diwaniyah. Participants will receive targeted consul…

This study tests a computer system called LingBao that helps doctors decide the best treatment for people having a stroke. About 3,000 adults from 20 stroke centers will take part. The system uses patient data to give treatment suggestions, but doctors make the final call. The go…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study tests two strategies for removing an external ventricular drain (a tube that drains fluid from the brain) in 170 adults who had a brain bleed. One method clamps the drain shut as soon as it's safe, while the other gradually raises the drain over time. The goal is to se…

This study looks at whether a substance in the blood called BDNF is linked to strokes caused by heart conditions like atrial fibrillation. Researchers will measure BDNF levels in 150 people who recently had a stroke and compare it with heart and brain scans. The goal is to better…

This study aims to translate and adapt an English scale (EmNSA) into French to better assess sensation in the legs of adults with acquired brain injury. Researchers will test the new French version on 50 patients to ensure it is accurate and reliable. The goal is to provide a val…

This study explores why stroke survivors often feel extreme muscle fatigue. Researchers will use a gentle, non-invasive brain stimulation technique called tACS to temporarily change brain activity in 120 stroke survivors. Participants will do leg exercises until tired while their…

This study tests if a non-invasive device called Electrical Impedance Tomography (EIT) can safely monitor brain blood flow in 100 ICU patients with conditions like stroke or brain bleeding. Currently, doctors must insert a probe into the skull to check this, which can cause infec…

This study adapts and tests a Spanish version of eTIPS, an early home-based therapy program for infants at risk of unilateral cerebral palsy after perinatal stroke. The program involves parent-delivered activities integrated into daily routines. The study will enroll 20 families …

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study looks at two common anesthetics used during carotid artery surgery to see which one better protects the brain from small areas of damage. About 160 adults having planned carotid surgery will get either an intravenous or inhaled anesthetic. Researchers will compare brai…

This study looks at whether a treadmill that moves each leg at a different speed can help people who had a stroke walk more evenly and faster. About 30 people who had a stroke within the last 9 months will take part. A physiotherapist will guide them through walking exercises on …

This study will test a new tool called the Stroke Mimics Score (SMS) in 1000 adults who come to the emergency room with stroke-like symptoms. The goal is to see if the SMS can accurately tell the difference between a real stroke and a condition that looks like a stroke but isn't …

This study looks at how well people who have had a stroke can imagine movements (motor imagery) and how that relates to their neglect, arm function, daily activities, and quality of life. Researchers will assess 50 participants using tests and questionnaires. The goal is to bette…

This study will use artificial intelligence (AI) to analyze eye scans from 554 adults with diabetic macular edema (DME). The goal is to see if AI can predict when a person's eye treatment needs to change. Participants will not receive any new treatment; instead, researchers will …

This observational study aims to understand how neuromuscular fatigue develops in stroke survivors compared to healthy individuals. Researchers will measure brain activity (EEG) and muscle activity (EMG) in 120 participants while they perform repeated leg exercises until fatigue.…

This study looks at whether people who had a stroke more than six months ago and cannot move their fingers can regain that ability. Researchers will use brain stimulation and nerve tests to understand who might benefit. Participants will receive electrical muscle stimulation and …

This study looks at whether being at a moderate altitude (like 4,000 meters) can hurt your ability to remember to do things later, called prospective memory. Fifty healthy adults will take memory tests while breathing low-oxygen air or normal air in a chamber. Researchers also wa…

This study looks at 117 people who had a brain bleed (intracerebral hemorrhage) to understand how inflammation and damage to the brain's protective barrier affect recovery. Participants will get special brain scans and blood tests about 10 days after the bleed. The goal is to lin…

This study will test whether wearing a magnet helmet every day can change brain inflammation linked to migraines. Ten adults with migraines will use the helmet and have brain scans before and after the treatment period. Researchers will also track migraine symptoms through questi…

This pilot study will use advanced MRI scans to create detailed maps of brain connections in 10 people who have had a stroke in the middle cerebral artery. The goal is to understand how stroke disrupts the brain's network and whether these maps can help predict recovery and guide…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study looks at 300 adults with a brain bleed from a ruptured aneurysm. It tests a non-invasive headband to monitor brain blood flow and two nerve treatments (a neck injection and ear stimulation) to see if they improve brain function. The goal is to find better ways to preve…

This study tests whether a gentle magnetic pulse called cTBS can improve attention in people who, after a stroke, ignore one side of their surroundings. Sixty adults with right-brain stroke and left-sided neglect will receive real or fake stimulation to the cerebellum or brain's …

This study tests a new way to recruit women into stroke research using easy-to-understand materials like brochures and videos. Researchers will compare this approach to usual recruitment methods with 1,600 participants. The goal is to make stroke studies more inclusive so treatme…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods (like the shot or implant) affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will join groups based on their contraceptive choice…

This study tests whether a personalized care approach helps patients with chronic macular diseases (like wet age-related macular degeneration and diabetic macular edema) attend their regular eye injection appointments. Many patients skip these vital treatments, risking further vi…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study follows 100 adults with diabetic eye disease who are already receiving standard anti-VEGF injections for swelling in the center of the retina. Researchers will use advanced vision tests and imaging to track changes over time. The goal is not to test a new drug, but to …

This study tests a digital platform called GetReady that helps doctors and patients track brain aneurysm follow-up data, including symptoms and quality of life. About 200 people with brain aneurysms will use the platform during routine care. The goal is to see if it improves heal…

This study will measure how sensitive people with episodic and chronic migraine are to pressure pain, and how that relates to their headache burden and quality of life. Researchers will compare a standard pressure pain device with a new tool called Algopeg, which is like a calibr…

This study looks at whether giving eye doctors AI-generated measurements from retinal images helps them write more accurate and complete reports. About 29 ophthalmologists and trainees will be randomly assigned to use AI tools or just the original images. A panel of senior expert…

This study will follow up to 12,750 stroke patients in Germany to learn how care is given from the moment symptoms start through hospital treatment, rehab, and long-term recovery. It includes both adults and children with ischemic stroke or brain bleeding. The goal is to collect …

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will follow 1,000 children under 18 who have had a stroke to see which treatments work best in everyday hospitals. Researchers will check their recovery, brain scans, and daily life over 6 months. The goal is to learn what helps children recover the most after a stroke…

This study looks at whether people with migraine have different motor imagery abilities—like mentally picturing movements—compared to healthy people. Researchers will use questionnaires, mental timing tests, and brain scans to measure these abilities. They also want to see if the…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complicatio…

This study examines whether blood electrolyte levels are linked to kidney damage in people who have a stroke and undergo a clot-removal procedure. Researchers will review medical records from 250 patients treated between 2018 and 2026. The goal is to identify risk factors that co…

This study will analyze eye and brain scans from over 200,000 people to see if eye images can predict brain diseases like small vessel disease and other health problems. Researchers will build computer models to map eye features to brain structure and disease diagnoses. No treatm…

This study looks at whether placing a catheter in a neck vein changes pressure inside the skull. Researchers will use ultrasound to measure the optic nerve sheath and carotid artery in 61 adults under general anesthesia. The goal is to understand short-term effects, not to test a…

This study tests a driving simulator designed to help people with neurological conditions like stroke, Parkinson's, ALS, or mild cognitive impairment improve their motor and thinking skills. About 60 participants (including healthy volunteers) will use the simulator to see if it …

This study looks at how short bursts of aerobic exercise affect brain function in older adults and stroke survivors. Researchers will compare three groups: one doing moderate cycling to raise lactate levels, one doing light cycling, and one receiving health education only. Partic…

This study looks at whether a clot-dissolving medicine called tenecteplase is safe and effective for people having a stroke when given more than 4.5 hours after symptoms began. Researchers will follow 3000 patients in China to see how many recover with little or no disability aft…

This study will track 3,000 stroke patients in China who received clot-busting medication more than 4.5 hours after their symptoms began. Researchers want to see if this later treatment is still safe and helps reduce disability. The study is observational, meaning it simply watch…

This study looks at whether people who have had a ruptured brain aneurysm also have an abdominal aortic aneurysm (a bulge in the main belly artery) that they don't know about. About 233 participants will get a painless belly ultrasound to check. The goal is to see how common this…

This study aims to validate a questionnaire called VM-PATHI for adolescents aged 10-20 with vestibular migraine, a condition causing dizziness and other symptoms. Researchers will test whether the tool accurately measures symptom severity and meaningful improvement. About 70 part…

This study tests whether a one-on-one nursing education session just before a stroke patient goes home can improve how well they follow their medication and care plan. Researchers will enroll 300 stroke survivors who are returning home and randomly assign half to receive the extr…

This study aims to find brain activity markers that can predict how well people recover after an ischemic stroke. Researchers will first study healthy volunteers to establish normal brain patterns, then test 120 stroke patients. Patients will receive either real or sham brain sti…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples. The goal is to find differences in a molecule called CGRP and hormone patterns that may …

This study tests whether a program called PEER-HOMEcare is practical and helpful for people recovering from stroke at home. The program involves therapists and family members working together to adapt the home environment and use wearable sensors to track movement. Researchers wi…

This study looks at how well stroke patients can move and how that affects the anxiety, depression, and burden of their caregivers. Researchers will assess 64 stroke patients and their family caregivers using mobility tests and mental health questionnaires. The goal is to underst…

This study will look at medical records of 170 patients aged 70 and older who were in the ICU for a bleeding stroke called aneurysmal subarachnoid hemorrhage. Researchers want to find out which factors are linked to poor recovery or death six months later. The goal is to help doc…

This study will follow 30 adults who have had a stroke and have arm weakness. Researchers will use functional MRI scans at several time points over six months to see how the brain reorganizes itself. The goal is to link different patterns of brain activity to different levels of …

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those …

This study compares two common head positions—lying flat (0°) versus raising the head 30°—for the first 24 hours after a severe ischemic stroke. Researchers want to see which position leads to better recovery and fewer complications. About 1,500 adults with severe stroke will be …

This study will look at brain scans (MRI/CT) and symptoms of over 1,100 people with cerebrovascular disease. The goal is to find patterns linking specific scan findings to different types of the disease. This could help doctors diagnose and treat these conditions more accurately …

This study will follow 450 people with diabetes (and some without) for several years to track how their eyes change. Researchers will use advanced eye tests like visual field analysis, contrast sensitivity, and retinal imaging to see which measurements best show disease progressi…

This study looks at how a device called the L300, which uses mild electrical pulses to lift the foot during walking, affects people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults to see if …

This study will check if certain walking and balance tests are reliable for people who had a stroke at least six months ago. Researchers will use a walking questionnaire, a 400-meter walk test, a falls confidence scale, and a vision test. The goal is to see if these tools can bet…

This study tests whether a smartphone app using AI can help personalize rehabilitation for adults who have had a stroke. Thirty participants will use the app daily for six weeks and keep a diary of their exercises. Researchers want to see if people can use the app and if it adapt…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study aims to find out how often headaches happen in people with MOGAD, a rare disease that affects the brain and nerves. Researchers will look at the medical records of 25 adults and also follow them forward in time to describe headache patterns. The goal is to better under…

This study looks at whether certain blood test results can help predict how severe a stroke is and how well a person might recover. Researchers will check three different ratios in the blood of 60 adults with acute ischemic stroke. The goal is to see if these simple, routine test…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study aims to create a version of the Mini-Mental State Examination (MMSE) that works better for people in Reunion Island. The current French version has questions that don't fit local culture. Researchers will test 400 people aged 60-89, both healthy and those with Alzheime…

This study tests a 5-week support program for stroke survivors after they leave the hospital. The goal is to see if the program helps them feel more confident and independent in managing their daily health. Researchers will compare participants who get the program plus usual care…

This study gives a natural brain chemical called adrenomedullin to 26 people with migraines to see if it triggers an attack. Participants first receive a migraine-preventing drug (erenumab) to block related receptors. The goal is to understand how migraines start, not to test a n…

This study looks at why some cancer patients develop neurological problems after receiving immunotherapy drugs called checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 participants to find immune cells that may mistakenly attack the nervous system. T…

This study will test whether an artificial intelligence (AI) tool can better predict stroke risk in 1,000 people aged 65-95 with atrial fibrillation, compared to current methods. The AI analyzes health records and heart data to identify high-risk individuals early. The goal is to…

This study watches brain oxygen levels and anesthesia depth in 75 adults during a procedure to fix a brain aneurysm. The goal is to see how these measurements relate to each other and to vital signs like blood pressure. No extra treatments are given—just careful observation to he…

This study will follow 400 people who come to the emergency room with sudden vertigo or dizziness that might be caused by a mini-stroke in the back of the brain. Researchers will track their symptoms, treatments, and outcomes over a year to learn how to better diagnose and manage…

This study evaluates a program that sends family doctors and nurse practitioners a confidential report comparing their antibiotic prescribing to peers, along with an educational summary. Over 7,600 practitioners in British Columbia will be randomly assigned to receive the report …

This study checks if a tool called the Hypertonia Assessment Tool (HAT) can correctly identify different types of muscle tightness in adults who have had a stroke. The tool was already tested in children with cerebral palsy, but not in adults after stroke. Researchers will test 6…

This study will test whether mild electrical brain stimulation, combined with physical therapy, changes brain activity in people who had a stroke. Sixty participants will receive either direct or alternating current stimulation during rehab sessions. Researchers will measure bloo…

This study aims to measure how the two sides of the brain communicate after a stroke using a safe, non-invasive technique called transcranial magnetic stimulation (TMS) combined with EEG and EMG. Researchers will test a new way to temporarily adjust these brain signals in 20 stro…

This study looks at children born prematurely who had retinopathy of prematurity (ROP), a disease that can cause blindness. Some were treated with laser, others with injections, and some had ROP but no treatment. Researchers will compare their vision and retina structure to see w…

This study tests whether an AI-powered app called HeartBot II can improve women's awareness of heart attack symptoms. About 200 women will be randomly assigned to use the app right away or wait 12 weeks. Participants complete surveys about their knowledge and confidence in recogn…

This study will compare two types of heart-lung machines used during coronary bypass surgery to see how they affect blood flow to the brain. Researchers will measure brain pressure using an eye ultrasound and brain oxygen levels with a forehead sensor in 70 patients. The goal is …