Eye ultrasound may spot hidden brain pressure spikes after trauma
NCT ID NCT07722702
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This study tests whether measuring the optic nerve sheath diameter — the nerve that connects the eye to the brain — with a simple bedside ultrasound can predict a dangerous rise in brain pressure when a pressure-lowering drug (mannitol) is reduced or stopped. Researchers will follow 100 adults with traumatic brain injury who are receiving mannitol, taking ultrasound measurements at several time points after the drug is weaned. The goal is to see if changes in the nerve sheath diameter can signal rebound intracranial hypertension before it becomes critical, potentially giving doctors a non-invasive early warning tool.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- optic nerve sheath diameter ultrasonography (a non-invasive ultrasound test)
- What this could lead to
- If the trajectory of optic nerve sheath diameter reliably predicts rebound intracranial hypertension, doctors could use a simple bedside ultrasound to catch dangerous pressure spikes early, potentially guiding safer weaning from osmotherapy.
- What could go wrong
- This is an observational study, not a treatment trial, so it cannot prove that using ONSD monitoring improves outcomes. The findings may not apply to all types of traumatic brain injury or to patients with eye conditions that prevent accurate measurement.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Benha university hospital
Banhā, Qalyobia, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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