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A quick eye ultrasound might spot brain pressure without a CT scan

NCT ID NCT07799714

Diagnosis Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
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Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
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The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether a bedside ultrasound of the eye can reliably detect raised pressure inside the skull, a condition that can damage the brain if not treated quickly. Researchers will measure the optic nerve sheath diameter in adults suspected of having high brain pressure and compare those readings with CT scan results, the current standard. The goal is to see if this quick, non-invasive test can serve as an accurate early warning tool.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bedside ultrasound measurement of the optic nerve sheath diameter
What this could lead to
If it works, this could give doctors a fast, non-invasive way to detect dangerous brain pressure at the bedside, potentially speeding up treatment and reducing the need for CT scans in some cases.
What could go wrong
This is a single-center study with 85 participants, and ultrasound accuracy can vary with the operator. The results may not apply to all patients or settings, and the test might not be precise enough to replace CT scans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 85 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients aged 18 years or older admitted to the emergency department or intensive care units at Assiut University Hospital with clinical suspicion of acutely raised intracranial pressure (such as altered level of consciousness, progressive headache, vomiting, papilledema, or focal neurological deficits) who are referred to the Diagnostic Radiology Department for a non-contrast brain CT scan.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged ≥ 18 years * Clinical suspicion of acutely raised intracranial pressure (e.g., altered level of consciousness, papilledema, progressive headache, vomiting, or focal neurological deficits) * Referred to undergo a brain CT scan * Hemodynamically stable at the time of ultrasound examination Exclusion Criteria: * Pre-existing orbital or ocular trauma * Known history of optic nerve disease (e.g., optic neuritis or glaucoma) * Previous ocular or intraorbital surgery * Severe ocular pathology preventing safe transorbital ultrasonographic assessment * Refusal to participate or lack of informed consent from the patient or legal guardian

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Conditions

The condition(s) this trial relates to.

brain edema Brain Injuries, Traumatic intracranial hypertension traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain edema Increased intracranial pressure Intracranial hypertension Traumatic brain injury

How to take part

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  1. The official record

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