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Brain surgery survivors: why do some lose memory years later?

NCT ID NCT07723131

Knowledge-focused Sponsor: University of Campinas, Brazil Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study investigates why some people develop long-term thinking and memory problems after surgery to repair a ruptured brain aneurysm. Researchers will review past medical records and then bring in 150 adult survivors for brain scans and cognitive tests. The goal is to identify early warning signs that could help doctors predict and manage late cognitive decline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors predict which patients are at higher risk for cognitive decline after aneurysm surgery and guide better rehabilitation plans.
What could go wrong
This is an observational study, not a treatment trial, so it will not test any new therapy. The findings may not apply to all patients or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients who underwent microsurgical clipping of ruptured cerebral aneurysms following aneurysmal subarachnoid hemorrhage (aSAH), with symptom onset occurring in or after 2020, and who are currently under outpatient follow-up at HC-UNICAMP, will be eligible for inclusion.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years at the time of aSAH. * Treatment by microsurgical clipping of a ruptured cerebral aneurysm. * Survival until study recruitment. * Ability to understand and sign informed consent. Exclusion Criteria: * Non-aneurysmal subarachnoid hemorrhage. * Exclusively endovascular treatment. * Previous diagnosis of dementia. * Severe neurological or psychiatric disorders unrelated to aSAH with significant cognitive impact. * Absolute contraindication to MRI. * Severe aphasia preventing adequate neuropsychological evaluation. * Incomplete clinical data. * Inability to attend in-person assessment.

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage Cognitive Dysfunction subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive impairment Microsurgery Subarachnoid aneurysm hemorrhage

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Clinics Hospital - UNICAMP

    Campinas, São Paulo, 13083888, Brazil

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