New drug combo may shrink bleeding plaques in neck arteries, cutting stroke risk
NCT ID NCT07586540
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding alirocumab (a cholesterol-lowering injection) to standard statin therapy can reduce bleeding inside fatty plaques in the carotid artery. About 280 people with a recent mini-stroke or stroke due to a 50-69% blocked neck artery will receive either alirocumab or a placebo every two weeks for 26 weeks, with MRI scans to measure plaque changes. The goal is to see if the drug makes plaques less dangerous and lowers the chance of future strokes.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aga Khan University
Karachi, Pakistan
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Ain Shams University
Cairo, Egypt
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Alexandria University, Smouha University Comprehensive Stroke Center
Alexandria, Egypt
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Amman Specialized IR Center
Amman, Jordan
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Cairo University
Cairo, Egypt
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Centre Hospitalier Universitaire Ibn Sina de Rabat
Rabat, Morocco
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Department of Neurology, Eskisehir Osmangazi University
Eskişehir, Turkey (Türkiye)
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Institut National de Neurologie
Tunis, Tunisia
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King Abdulaziz Medical City
Jeddah, Saudi Arabia
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King Abdullah Medical City
Mecca, Saudi Arabia
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King Khalid University
Abhā, Saudi Arabia
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Neurology Department, Al-Azhar University
Cairo, Egypt
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Neurology Department, Dr. Lutfi Kirdar City Hospital
Istanbul, Turkey (Türkiye)
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Weill Cornell Medicine-Qatar
Doha, Qatar