Stroke drug boost: could tenecteplase finish the job?

NCT ID NCT07471282

Not yet recruiting Disease control Sponsor: Chuansheng Zhao Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery can help stroke patients who still have blocked blood flow after a standard clot removal procedure. About 344 adults with a major stroke will be randomly assigned to receive either the drug or a placebo. The goal is to see if the drug improves recovery and reduces disability at 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tenecteplase (a clot-busting drug)
What this could lead to: If it works, this could provide a better way to restore blood flow and improve recovery for stroke patients whose arteries aren't fully cleared by the standard procedure.
What could go wrong: This is a Phase 3 trial, but it's still early to know if the drug will be effective or safe. There is a risk of bleeding in the brain, and the results may not apply to all stroke types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebral artery occlusion large artery stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STROKE

Contacts and locations

Locations

The First Affiliated Hospital of China Medical University

Shenyang, Liaoning, 110000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.