Cerebral artery occlusion

This phase 3 trial tests whether giving a clot-busting drug called rhPro-UK before a mechanical clot removal procedure improves recovery for people with severe stroke. About 820 participants who had a stroke 4.5 to 24 hours earlier will receive either the drug or a placebo, follo…

This study tests whether taking stroke patients directly to a special imaging and treatment room (angio suite) speeds up care compared to the usual approach of getting a CT or MRI first. About 594 adults with severe stroke symptoms will be randomly assigned to one of the two path…

This study compares two ways to remove blood clots from the brain during a stroke. About 500 adults who have a stroke from a large blocked artery will be randomly assigned to one of two standard techniques: a cyclic 'plunger' method or a steady suction method. The goal is to see …

This trial investigates whether giving a low dose of the clot-busting drug alteplase directly into the brain artery, right after successful mechanical clot removal, can improve recovery in people with a severe stroke caused by a large vessel blockage. About 416 adults who have ha…

This study looks at whether giving a clot-dissolving drug called Tenecteplase to stroke patients before they are moved to a hospital that can perform a clot-removal procedure improves their recovery. The trial involves 572 adults who had a stroke caused by a large blockage in the…

This study looks at whether removing a blood clot from a medium-sized brain artery (M2 segment) helps people recover better after a stroke. About 200 adults who have had a stroke and are not helped by clot-busting medicine will be randomly assigned to get either standard care or …

This study tests whether adding GM1, a natural brain substance, to standard clot-removal treatment helps people recover better after a severe stroke. About 868 adults in China who have a blocked artery in the front part of the brain will receive either GM1 or a placebo daily for …

This study tests whether the drug sivelestat sodium, given alongside standard clot-removal surgery, can help people recover better after a major stroke. The trial will include 868 adults aged 18-80 with large-vessel blockage in the front part of the brain. The goal is to see if t…

This study tests whether the antibiotic minocycline can improve recovery in people who have had a major stroke and undergone a procedure to remove a blood clot from a large brain artery. Even when the clot is successfully removed, many patients still have significant disability. …

This study compares a procedure to remove blood clots (endovascular therapy) with standard medical care for people who have had a mild stroke caused by a blockage in a large brain artery. About 264 adults with mild symptoms (NIHSS score 2-5) will be enrolled within 24 hours of st…

This study tests whether giving the steroid methylprednisolone right after a stroke clot removal procedure can help patients recover better. About 210 adults who had a major stroke from a blocked artery in the brain will be randomly assigned to receive either the steroid or a pla…

This study tests whether performing skull surgery early, before dangerous brain swelling occurs, can improve outcomes for people who have had a severe stroke and are at high risk of swelling. About 380 adults aged 18–75 will be randomly assigned to receive either early surgery pl…

This study tests whether giving a clot-busting drug (rhTNK-tPA) before a clot-removal procedure helps stroke patients who arrive 4.5 to 24 hours after symptoms start. About 820 adults with a blocked large artery in the brain will receive either the drug or a placebo. The goal is …

This study compares two types of general anesthesia during emergency clot removal for stroke patients. The goal is to see which method better maintains blood flow to the brain and improves recovery. About 90 adults with severe stroke will take part at two hospitals in Los Angeles…

This study tests two different medicines given before a procedure to remove a blood clot from the brain in people having a major stroke. The goal is to see which medicine helps more people recover with little or no disability. About 800 adults who arrive at the hospital within 24…

This study compares two treatments for stroke patients whose brain arteries remain blocked after initial clot removal, due to underlying hardening of the arteries (atherosclerosis). About 498 participants will be randomly assigned to receive either urgent stenting or continued st…

This global study tests whether a procedure that removes blood clots from the brain can safely help stroke patients treated up to 72 hours after symptoms start, using only a basic CT scan that is available in most hospitals. Currently, this treatment is only proven within 6 hours…

This study tests a new device called the CONDA stent retriever, which is used to remove blood clots from the brain in people having a stroke. About 50 patients will be treated within 24 hours of their symptoms starting. The goal is to see if the device is safe and works well at r…

This study looks at 958 people having a severe stroke to find out if general anesthesia (being fully asleep) or procedural sedation (being drowsy but breathing on your own) leads to better recovery after a procedure to remove a blood clot from the brain. Participants will be rand…

This observational study will follow 180 stroke patients who had a clot-removal procedure. Researchers will measure brain blood flow and electrical activity at days 1-3 and day 7 after treatment. The goal is to see if early changes in brain function can predict how well patients …

This study looks at 50 adults who had a stroke caused by a blocked middle brain artery and were treated with a clot-removal procedure called thrombectomy. Researchers will use special MRI scans to measure brain activity and metabolism in the damaged area. The goal is to find earl…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study is testing whether a gentle electrical stimulation of a nerve in the ear (the vagus nerve) can reduce brain injury and inflammation after a severe stroke. Researchers will measure brain damage markers in the blood of 65 participants over a week. The goal is to see if t…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…