Cerebral artery occlusion

This phase 3 trial tests whether a new emergency stroke unit, equipped with a hybrid CT and X-ray machine (NeuAngio-CT), can speed up clot removal in people having a severe stroke. About 232 adults aged 18-60 with acute ischemic stroke will be randomly assigned to either the new …

This study compares two ways to remove blood clots from the brain during a stroke. About 500 adults who have a stroke from a large blocked artery will be randomly assigned to one of two standard techniques: a cyclic 'plunger' method or a steady suction method. The goal is to see …

This study tests whether a personalized weaning strategy can help adults with chronic heart, brain, or lung conditions leave ventilators earlier. The strategy tailors care based on the main reason a patient struggles to breathe on their own, such as heart or muscle problems. Rese…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests whether giving a drug called tirofiban directly into the artery right after a clot is removed can help people recover better from a severe stroke. About 344 adults who had a large-vessel blockage stroke will be randomly assigned to receive the drug or not. The ma…

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This study compares two approaches for people who have had a stroke or mini-stroke due to a blocked brain artery that hasn't opened on its own. One group gets a procedure to reopen the artery plus medication, while the other gets medication alone. The goal is to see which approac…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery can help stroke patients who still have blocked blood flow after a standard clot removal procedure. About 344 adults with a major stroke will be randomly assigned to receive eit…

This study tests whether sending people with suspected severe stroke directly to the angiography suite (instead of first getting a CT or MRI) can speed up treatment and improve recovery. About 568 adults with stroke symptoms within 6 hours will be randomly assigned to the direct …

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This phase 3 trial tests whether giving a clot-busting drug called rhPro-UK before a mechanical clot removal procedure improves recovery for people with severe stroke. About 820 participants who had a stroke 4.5 to 24 hours earlier will receive either the drug or a placebo, follo…

This Phase 2 trial tests whether giving human albumin directly into the artery supplying the brain, right after a clot is removed, can improve recovery in people with severe stroke. About 306 participants will be randomly assigned to receive either standard clot removal alone or …

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study tests whether giving a clot-busting drug directly into the brain artery, plus possibly removing the clot with a device, helps people with medium-sized stroke clots. About 614 participants who cannot receive standard IV clot-busters will be randomly assigned to either t…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study tests whether giving a protein called albumin directly into the artery during a stroke procedure can reduce brain damage. Sixty adults with a severe stroke will receive either standard treatment alone or standard treatment plus albumin. The goal is to see if albumin he…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests whether the clot-busting drug tenecteplase can improve recovery in people who have a major stroke caused by a large blocked artery, but who cannot have a procedure to remove the clot. The trial includes 794 adults who arrive at the hospital 4.5 to 24 hours after …

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study will test a new rapid blood test that can be done at the bedside to help doctors quickly tell if a child is having a stroke. About 250 children with stroke symptoms will give a small blood sample, and the test's accuracy will be compared to standard brain scans. The go…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complicatio…

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those …

This study will look at brain scans (MRI/CT) and symptoms of over 1,100 people with cerebrovascular disease. The goal is to find patterns linking specific scan findings to different types of the disease. This could help doctors diagnose and treat these conditions more accurately …

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This observational study will follow 180 stroke patients who had a clot-removal procedure. Researchers will measure brain blood flow and electrical activity at days 1-3 and day 7 after treatment. The goal is to see if early changes in brain function can predict how well patients …

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study looks at whether lying flat (0 degrees) or with the head raised (30 degrees or more) after a stroke clot removal procedure helps people recover better. About 2240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two hea…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study looks at 958 people having a severe stroke to find out if general anesthesia (being fully asleep) or procedural sedation (being drowsy but breathing on your own) leads to better recovery after a procedure to remove a blood clot from the brain. Participants will be rand…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…