Could adding Clot-Busting drugs before surgery boost stroke recovery?

NCT ID NCT07748039

Not yet recruiting Disease control Sponsor: Yongjun Wang Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether giving a clot-busting drug before mechanical thrombectomy (a procedure to physically remove a blood clot) improves outcomes for people with severe strokes caused by large vessel occlusion. Participants are randomly assigned to receive tenecteplase, reteplase, or no clot-busting drug before the procedure. The main goal is to see if more people achieve functional independence at 90 days after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tenecteplase or reteplase (clot-busting drugs) given before mechanical thrombectomy
What this could lead to: If successful, this could establish the best approach to treating severe strokes, potentially improving recovery and reducing disability for many patients.
What could go wrong: The trial is large but still experimental; the drugs may not improve outcomes over direct clot removal and carry a risk of bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain infarction cerebral artery occlusion ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE ANTERIOR CIRCULATION BRAIN INFARCTION LARGE VESSEL OCCLUSION

Contacts and locations

Locations

Beijing Tiantan Hospital, Capital Medical Universiity

Beijing, Beijing Municipality, 100070, China
Rizhao Hospital of Traditional Chinese Medicine

Rizhao, Shandong, 625000, China
Xiangtan Central Hospital

Xiangtan, Hunan, 411100, China
Ya'an People's Hospital

Ya'an, Sichuan, 625000, China
Zhongnan Hospital of Wuhan University

Wuhan, Hubei, 430071, China

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