Can a Low-Dose clot buster boost recovery after stroke clot removal?

NCT ID NCT07727395

Recruiting now Disease control Sponsor: 115 People's Hospital Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Aug 12, 2026 · Updated 5 times

Summary

This trial investigates whether giving a low dose of the clot-busting drug alteplase directly into the brain artery, right after successful mechanical clot removal, can improve recovery in people with a severe stroke caused by a large vessel blockage. About 416 adults who have had a stroke and achieved good blood flow restoration within 24 hours will be randomly assigned to receive either the extra drug plus standard care or standard care alone. The main goal is to see if more people regain functional independence—being able to carry out daily activities without help—at 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a clot-busting drug called alteplase, given directly into the brain artery after mechanical clot removal
What this could lead to: If it works, this approach could become a new standard treatment to improve functional independence after a severe stroke.
What could go wrong: This is a Phase 3 trial, but the added drug may increase the risk of bleeding in the brain. The benefit may not outweigh the risk for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebral artery occlusion ischemic stroke large artery stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LARGE VESSEL OCCLUSION STROKE, ACUTE ISCHEMIC THROMBECTOMY

Contacts and locations

Locations

175 Military Hospital
NOT_YET_RECRUITING

Ho Chi Minh City, 700000, Vietnam
Can Tho Central General Hospital
RECRUITING

Can Tho, 900000, Vietnam
Chau Doc General Hospital
NOT_YET_RECRUITING

An Giang, 90000, Vietnam
Da Nang Hospital
RECRUITING

Da Nang, 550000, Vietnam
Hanoi Medical University Hospital
NOT_YET_RECRUITING

Hà Nội, 100000, Vietnam
Hue Central Hospital
NOT_YET_RECRUITING

Huế, 530000, Vietnam
Military Hospital 103
NOT_YET_RECRUITING

Hà Nội, 100000, Vietnam
People's Hospital 115
RECRUITING

Ho Chi Minh City, 700000, Vietnam
Thong Nhat Hospital
NOT_YET_RECRUITING

Ho Chi Minh City, 700000, Vietnam
Viet Tiep Friendship Hospital
RECRUITING

Haiphong, 180000, Vietnam

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